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Protein

Polyadenylate-binding protein

Gene

PABPC4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds the poly(A) tail of mRNA.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding proteinUniRule annotation
Short name:
PABPUniRule annotation
Gene namesi
Name:PABPC4Imported
ORF Names:hCG_2031827Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8557. PABPC4.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiB1ANR0.

Expressioni

Gene expression databases

BgeeiENSG00000090621.

Structurei

3D structure databases

SMRiB1ANR0. Positions 10-376, 481-614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 8979RRM (RNA recognition motif)InterPro annotationAdd
BLAST
Domaini99 – 17577RRM (RNA recognition motif)InterPro annotationAdd
BLAST
Domaini191 – 26878RRM (RNA recognition motif)InterPro annotationAdd
BLAST
Domaini294 – 37077RRM (RNA recognition motif)InterPro annotationAdd
BLAST
Domaini522 – 59978PABCInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyadenylate-binding protein type-1 family.UniRule annotation
Contains 1 PABC domain.UniRule annotation
Contains 4 RRM (RNA recognition motif) domains.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118913.
HOGENOMiHOG000217922.
HOVERGENiHBG002295.

Family and domain databases

Gene3Di1.10.1900.10. 1 hit.
3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR006515. PABP_1234.
IPR002004. PABP_HYD.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00658. PABP. 1 hit.
PF00076. RRM_1. 4 hits.
[Graphical view]
SMARTiSM00517. PolyA. 1 hit.
SM00360. RRM. 4 hits.
SM00361. RRM_1. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
SSF63570. SSF63570. 1 hit.
TIGRFAMsiTIGR01628. PABP-1234. 1 hit.
PROSITEiPS51309. PABC. 1 hit.
PS50102. RRM. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1ANR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAAASSYPM ASLYVGDLHS DVTEAMLYEK FSPAGPVLSI RVCRDMITRR
60 70 80 90 100
SLGYAYVNFQ QPADAERALD TMNFDVIKGK PIRIMWSQRD PSLRKSGVGN
110 120 130 140 150
VFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY AFVHFETQEA
160 170 180 190 200
ADKAIEKMNG MLLNDRKVFV GRFKSRKERE AELGAKAKEF TNVYIKNFGE
210 220 230 240 250
EVDDESLKEL FSQFGKTLSV KVMRDPNGKS KGFGFVSYEK HEDANKAVEE
260 270 280 290 300
MNGKEISGKI IFVGRAQKKV ERQAELKRKF EQLKQERISR YQGVNLYIKN
310 320 330 340 350
LDDTIDDEKL RKEFSPFGSI TSAKVMLEDG RSKGFGFVCF SSPEEATKAV
360 370 380 390 400
TEMNGRIVGS KPLYVALAQR KEERKAHLTN QYMQRVAGMR ALPANAILNQ
410 420 430 440 450
FQPAAGGYFV PAVPQAQGRP PYYTPNQLAQ MRPNPRWQQG GRPQGFQGMP
460 470 480 490 500
SAIRQSGPRP TLRHLAPTGV PTAVQNLAPR AAVAAAAPRA VAPYKYASSV
510 520 530 540 550
RSPHPAIQPL QAPQPAVHVQ GQEPLTASML AAAPPQEQKQ MLGERLFPLI
560 570 580 590 600
QTMHSNLAGK ITGMLLEIDN SELLHMLESP ESLRSKVDEA VAVLQAHHAK
610
KEAAQKVGAV AAATS
Length:615
Mass (Da):67,971
Last modified:April 8, 2008 - v1
Checksum:i1C49036EFEBCBC9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365277 Genomic DNA. No translation available.
AL845289 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07265.1.
UniGeneiHs.169900.

Genome annotation databases

EnsembliENST00000372862; ENSP00000361953; ENSG00000090621.
UCSCiuc057fbl.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365277 Genomic DNA. No translation available.
AL845289 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07265.1.
UniGeneiHs.169900.

3D structure databases

SMRiB1ANR0. Positions 10-376, 481-614.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB1ANR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372862; ENSP00000361953; ENSG00000090621.
UCSCiuc057fbl.1. human.

Organism-specific databases

HGNCiHGNC:8557. PABPC4.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118913.
HOGENOMiHOG000217922.
HOVERGENiHBG002295.

Miscellaneous databases

ChiTaRSiPABPC4. human.

Gene expression databases

BgeeiENSG00000090621.

Family and domain databases

Gene3Di1.10.1900.10. 1 hit.
3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR006515. PABP_1234.
IPR002004. PABP_HYD.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00658. PABP. 1 hit.
PF00076. RRM_1. 4 hits.
[Graphical view]
SMARTiSM00517. PolyA. 1 hit.
SM00360. RRM. 4 hits.
SM00361. RRM_1. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
SSF63570. SSF63570. 1 hit.
TIGRFAMsiTIGR01628. PABP-1234. 1 hit.
PROSITEiPS51309. PABC. 1 hit.
PS50102. RRM. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB1ANR0_HUMAN
AccessioniPrimary (citable) accession number: B1ANR0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.