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B1ANE3

- B1ANE3_HUMAN

UniProt

B1ANE3 - B1ANE3_HUMAN

Protein
Submitted name:

Methionine synthase

Gene

MTR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Cofactori

    Cobalamin.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi339 – 3391Cobalt (cobalamin axial ligand)UniRule annotation
    Binding sitei528 – 5281S-adenosyl-L-methionineUniRule annotation
    Binding sitei726 – 7261S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei730 – 7301Cobalamin; via carbonyl oxygenUniRule annotation

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. methionine synthase activity Source: InterPro
    3. S-adenosylmethionine-homocysteine S-methyltransferase activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. pteridine-containing compound metabolic process Source: InterPro

    Keywords - Ligandi

    CobalaminUniRule annotation, Cobalt, Metal-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Methionine synthaseImported
    Gene namesi
    Name:MTRImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:7468. MTR.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Proteomic databases

    PRIDEiB1ANE3.

    Expressioni

    Gene expression databases

    ArrayExpressiB1ANE3.

    Structurei

    3D structure databases

    ProteinModelPortaliB1ANE3.
    SMRiB1ANE3. Positions 2-819.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni414 – 4152Cobalamin-bindingUniRule annotation
    Regioni781 – 7822S-adenosyl-L-methionine bindingUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000251409.
    HOVERGENiHBG006347.

    Family and domain databases

    Gene3Di1.10.1240.10. 1 hit.
    3.10.196.10. 1 hit.
    3.20.20.20. 2 hits.
    3.40.50.280. 1 hit.
    InterProiIPR003759. Cbl-bd_cap.
    IPR006158. Cobalamin-bd.
    IPR011005. Dihydropteroate_synth-like.
    IPR011822. MetH.
    IPR000489. Pterin-binding.
    IPR004223. VitB12-dep_Met_synth_activ_dom.
    [Graphical view]
    PfamiPF02310. B12-binding. 1 hit.
    PF02607. B12-binding_2. 1 hit.
    PF02965. Met_synt_B12. 1 hit.
    PF00809. Pterin_bind. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000381. MetH. 1 hit.
    SMARTiSM01018. B12-binding_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47644. SSF47644. 1 hit.
    SSF51717. SSF51717. 1 hit.
    SSF52242. SSF52242. 1 hit.
    SSF56507. SSF56507. 1 hit.
    TIGRFAMsiTIGR02082. metH. 1 hit.
    PROSITEiPS50974. ADOMET_ACTIVATION. 1 hit.
    PS51332. B12_BINDING. 1 hit.
    PS51337. B12_BINDING_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    B1ANE3-1 [UniParc]FASTAAdd to Basket

    « Hide

    GMLDGPSAMT RFCNLIASEP DIAKVPLCID SSNFAVIEAG LKCCQGKCIV    50
    NSISLKEGEA TETDTKIRVC TRAYHLLVKK LGFNPNDIIF DPNILTIGTG 100
    MEEHNLYAIN FIHATKVIKE TLPGARISGG LSNLSFSFRG MEAIREAMHG 150
    VFLYHAIKSG MDMGIVNAGN LPVYDDIHKE LLQLCEDLIW NKDPEATEKL 200
    LRYAQTQGTG GKKVIQTDEW RNGPVEERLE YALVKGIEKH IIEDTEEARL 250
    NQKKYPRPLN IIEGPLMNGM KIVGDLFGAG KMFLPQVIKS ARVMKKAVGH 300
    LIPFMEKERE ETRVLNGTVE EEDPYQGTIV LATVKGDVHD IGKNIVGVVL 350
    GCNNFRVIDL GVMTPCDKIL KAALDHKADI IGLSGLITPS LDEMIFVAKE 400
    MERLAIRIPL LIGGATTSKT HTAVKIAPRY SAPVIHVLDA SKSVVVCSQL 450
    LDENLKDEYF EEIMEEYEDI RQDHYESLKE RRYLPLSQAR KSGFQMDWLS 500
    EPHPVKPTFI GTQVFEDYDL QKLVDYIDWK PFFDVWQLRG KYPNRGFPKI 550
    FNDKTVGGEA RKVYDDAHNM LNTLISQKKL RARGVVGFWP AQSIQDDIHL 600
    YAEAAVPQAA EPIATFYGLR QQAEKDSAST EPYYCLSDFI APLHSGIRDY 650
    LGLFAVACFG VEELSKAYED DGDDYSSIMV KALGDRLAEA FAEELHERVR 700
    RELWAYCGSE QLDVADLRRL RYKGIRPAPG YPSQPDHTEK LTMWRLADIE 750
    QSTGIRLTES LAMAPASAVS GLYFSNLKSK YFAVGKISKD QVEDYALRKN 800
    ISVAEVEKWL GPILGYDTD 819
    Length:819
    Mass (Da):91,780
    Last modified:April 8, 2008 - v1
    Checksum:i412970EB2FA276A1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL359185 Genomic DNA. No translation available.
    AL359259 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000366576; ENSP00000355535; ENSG00000116984.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL359185 Genomic DNA. No translation available.
    AL359259 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali B1ANE3.
    SMRi B1ANE3. Positions 2-819.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B1ANE3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366576 ; ENSP00000355535 ; ENSG00000116984 .

    Organism-specific databases

    HGNCi HGNC:7468. MTR.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000251409.
    HOVERGENi HBG006347.

    Miscellaneous databases

    ChiTaRSi MTR. human.
    NextBioi 35466814.

    Gene expression databases

    ArrayExpressi B1ANE3.

    Family and domain databases

    Gene3Di 1.10.1240.10. 1 hit.
    3.10.196.10. 1 hit.
    3.20.20.20. 2 hits.
    3.40.50.280. 1 hit.
    InterProi IPR003759. Cbl-bd_cap.
    IPR006158. Cobalamin-bd.
    IPR011005. Dihydropteroate_synth-like.
    IPR011822. MetH.
    IPR000489. Pterin-binding.
    IPR004223. VitB12-dep_Met_synth_activ_dom.
    [Graphical view ]
    Pfami PF02310. B12-binding. 1 hit.
    PF02607. B12-binding_2. 1 hit.
    PF02965. Met_synt_B12. 1 hit.
    PF00809. Pterin_bind. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000381. MetH. 1 hit.
    SMARTi SM01018. B12-binding_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47644. SSF47644. 1 hit.
    SSF51717. SSF51717. 1 hit.
    SSF52242. SSF52242. 1 hit.
    SSF56507. SSF56507. 1 hit.
    TIGRFAMsi TIGR02082. metH. 1 hit.
    PROSITEi PS50974. ADOMET_ACTIVATION. 1 hit.
    PS51332. B12_BINDING. 1 hit.
    PS51337. B12_BINDING_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiB1ANE3_HUMAN
    AccessioniPrimary (citable) accession number: B1ANE3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3