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Protein
Submitted name:

Cdc42 guanine nucleotide exchange factor (GEF) 9, isoform CRA_c

Gene

ARHGEF9

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Cdc42 guanine nucleotide exchange factor (GEF) 9, isoform CRA_cImported
Submitted name:
Rho guanine nucleotide exchange factor 9Imported
Gene namesi
Name:ARHGEF9Imported
ORF Names:hCG_17692Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14561. ARHGEF9.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131089.

Expressioni

Gene expression databases

BgeeiENSG00000131089.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000253401.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 74SH3InterPro annotationAdd BLAST60
Domaini110 – 294DH (DBL-homology)InterPro annotationAdd BLAST185
Domaini325 – 432PHInterPro annotationAdd BLAST108

Phylogenomic databases

eggNOGiKOG3519. Eukaryota.
ENOG410XT9S. LUCA.
GeneTreeiENSGT00760000118925.
HOGENOMiHOG000237363.
HOVERGENiHBG050568.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

B1AMR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWIRGGSGM LITGDSIVSA EAVWDHVTMA NRELAFKAGD VIKVLDASNK
60 70 80 90 100
DWWWGQIDDE EGWFPASFVR LWVNQEDEVE EGPSDVQNGH LDPNSDCLCL
110 120 130 140 150
GRPLQNRDQM RANVINEIMS TERHYIKHLK DICEGYLKQC RKRRDMFSDE
160 170 180 190 200
QLKVIFGNIE DIYRFQMGFV RDLEKQYNND DPHLSEIGPC FLEHQDGFWI
210 220 230 240 250
YSEYCNNHLD ACMELSKLMK DSRYQHFFEA CRLLQQMIDI AIDGFLLTPV
260 270 280 290 300
QKICKYPLQL AELLKYTAQD HSDYRYVAAA LAVMRNVTQQ INERKRRLEN
310 320 330 340 350
IDKIAQWQAS VLDWEGEDIL DRSSELIYTG EMAWIYQPYG RNQQRVFFLF
360 370 380 390 400
DHQMVLCKKD LIRRDILYYK GRIDMDKYEV VDIEDGRDDD FNVSMKNAFK
410 420 430 440 450
LHNKETEEIH LFFAKKLEEK IRWLRAFREE RKMVQEDEKI GFEISENQKR
460 470 480
QAAMTVRKLP FPQLSEARIC SPKGFASVFN GTCCGES
Length:487
Mass (Da):57,405
Last modified:November 26, 2014 - v2
Checksum:iC7D07D8344BB1874
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355142 Genomic DNA. No translation available.
AL391277 Genomic DNA. No translation available.
AL451106 Genomic DNA. No translation available.
CH471132 Genomic DNA. Translation: EAX05418.1.
UniGeneiHs.54697.
Hs.734375.

Genome annotation databases

EnsembliENST00000374878; ENSP00000364012; ENSG00000131089.
UCSCiuc064zpg.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355142 Genomic DNA. No translation available.
AL391277 Genomic DNA. No translation available.
AL451106 Genomic DNA. No translation available.
CH471132 Genomic DNA. Translation: EAX05418.1.
UniGeneiHs.54697.
Hs.734375.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000253401.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374878; ENSP00000364012; ENSG00000131089.
UCSCiuc064zpg.1. human.

Organism-specific databases

HGNCiHGNC:14561. ARHGEF9.
OpenTargetsiENSG00000131089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3519. Eukaryota.
ENOG410XT9S. LUCA.
GeneTreeiENSGT00760000118925.
HOGENOMiHOG000237363.
HOVERGENiHBG050568.

Miscellaneous databases

ChiTaRSiARHGEF9. human.

Gene expression databases

BgeeiENSG00000131089.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00018. SH3_1. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB1AMR4_HUMAN
AccessioniPrimary (citable) accession number: B1AMR4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: November 26, 2014
Last modified: March 15, 2017
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.