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Protein
Submitted name:

Rho guanine nucleotide exchange factor 7

Gene

ARHGEF7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 7Imported
Gene namesi
Name:ARHGEF7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:15607. ARHGEF7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102606.

PTM / Processingi

Proteomic databases

EPDiB1ALK7.
MaxQBiB1ALK7.
PaxDbiB1ALK7.
PeptideAtlasiB1ALK7.
PRIDEiB1ALK7.

Expressioni

Gene expression databases

BgeeiENSG00000102606.
ExpressionAtlasiB1ALK7. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiB1ALK7. 1 interactor.
STRINGi9606.ENSP00000364893.

Structurei

3D structure databases

ProteinModelPortaliB1ALK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 65SH3InterPro annotationAdd BLAST60
Domaini93 – 273DH (DBL-homology)InterPro annotationAdd BLAST181
Domaini295 – 400PHInterPro annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili653 – 694Sequence analysisAdd BLAST42

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2070. Eukaryota.
ENOG410XNNP. LUCA.
GeneTreeiENSGT00760000118925.
HOGENOMiHOG000231381.
HOVERGENiHBG050569.
OMAiPQMKSLY.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR032409. GEF_CC.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF16523. betaPIX_CC. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1ALK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNSNNQLV VRAKFNFQQT NEDELSFSKG DVIHVTRVEE GGWWEGTLNG
60 70 80 90 100
RTGWFPSNYV REVKASEKPV SPKSGTLKSP PKGFDTTAIN KSYYNVVLQN
110 120 130 140 150
ILETENEYSK ELQTVLSTYL RPLQTSEKLS SANISYLMGN LEEICSFQQM
160 170 180 190 200
LVQSLEECTK LPEAQQRVGG CFLNLMPQMK TLYLTYCANH PSAVNVLTEH
210 220 230 240 250
SEELGEFMET KGASSPGILV LTTGLSKPFM RLDKYPTLLK ELERHMEDYH
260 270 280 290 300
TDRQDIQKSM AAFKNLSAQC QEVRKRKELE LQILTEAIRN WEGDDIKTLG
310 320 330 340 350
NVTYMSQVLI QCAGSEEKNE RYLLLFPNVL LMLSASPRMS GFIYQGKLPT
360 370 380 390 400
TGMTITKLED SENHRNAFEI SGSMIERILV SCNNQQDLQE WVEHLQKQTK
410 420 430 440 450
VTSVGNPTIK PHSVPSHTLP SHPVTPSSKH ADSKPAPLTP AYHTLPHPSH
460 470 480 490 500
HGTPHTTINW GPLEPPKTPK PWSLSCLRPA PPLRPSAALC YKEDLSKSPK
510 520 530 540 550
TMKKLLPKRK PERKPSDEEF ASRKSTAALE EDAQILKVIE AYCTSAKTRQ
560 570 580 590 600
TLNSTWQGTD LMHNHVLADD DQPSLDSLGR RSSLSRLEPS DLSEDSDYDS
610 620 630 640 650
IWTAHSYRMG STSRSRKESA PQVLLPEEEK IIVEETKSNG QTVIEEKSLV
660 670 680 690 700
DTVYALKDEV QELRQDNKKM KKSLEEEQRA RKDLEKLVRK VLKNMNDPAW

DETNL
Length:705
Mass (Da):79,832
Last modified:April 8, 2008 - v1
Checksum:i5A1E4E9A3437AD94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139086 Genomic DNA. No translation available.
AL353704 Genomic DNA. No translation available.
AL390754 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000218789; ENSP00000218789; ENSG00000102606.
UCSCiuc058yii.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139086 Genomic DNA. No translation available.
AL353704 Genomic DNA. No translation available.
AL390754 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB1ALK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB1ALK7. 1 interactor.
STRINGi9606.ENSP00000364893.

Proteomic databases

EPDiB1ALK7.
MaxQBiB1ALK7.
PaxDbiB1ALK7.
PeptideAtlasiB1ALK7.
PRIDEiB1ALK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218789; ENSP00000218789; ENSG00000102606.
UCSCiuc058yii.1. human.

Organism-specific databases

HGNCiHGNC:15607. ARHGEF7.
OpenTargetsiENSG00000102606.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2070. Eukaryota.
ENOG410XNNP. LUCA.
GeneTreeiENSGT00760000118925.
HOGENOMiHOG000231381.
HOVERGENiHBG050569.
OMAiPQMKSLY.

Miscellaneous databases

ChiTaRSiARHGEF7. human.

Gene expression databases

BgeeiENSG00000102606.
ExpressionAtlasiB1ALK7. baseline and differential.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR032409. GEF_CC.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF16523. betaPIX_CC. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB1ALK7_HUMAN
AccessioniPrimary (citable) accession number: B1ALK7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.