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Protein
Submitted name:

Rho guanine nucleotide exchange factor 7

Gene

ARHGEF7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 7Imported
Gene namesi
Name:ARHGEF7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102606.17
HGNCiHGNC:15607 ARHGEF7

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102606

PTM / Processingi

Proteomic databases

EPDiB1ALK7
MaxQBiB1ALK7
PeptideAtlasiB1ALK7
PRIDEiB1ALK7

Expressioni

Gene expression databases

BgeeiENSG00000102606
ExpressionAtlasiB1ALK7 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiB1ALK7, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliB1ALK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 65SH3InterPro annotationAdd BLAST60
Domaini93 – 273DHInterPro annotationAdd BLAST181
Domaini295 – 400PHInterPro annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili239 – 259Sequence analysisAdd BLAST21
Coiled coili274 – 294Sequence analysisAdd BLAST21
Coiled coili653 – 694Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2070 Eukaryota
ENOG410XNNP LUCA
GeneTreeiENSGT00910000144147
HOGENOMiHOG000231381
HOVERGENiHBG050569
OMAiSAINKSY

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd12061 SH3_betaPIX, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035789 BetaPIX_SH3
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR032409 GEF_CC
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF16523 betaPIX_CC, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

B1ALK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDNSNNQLV VRAKFNFQQT NEDELSFSKG DVIHVTRVEE GGWWEGTLNG
60 70 80 90 100
RTGWFPSNYV REVKASEKPV SPKSGTLKSP PKGFDTTAIN KSYYNVVLQN
110 120 130 140 150
ILETENEYSK ELQTVLSTYL RPLQTSEKLS SANISYLMGN LEEICSFQQM
160 170 180 190 200
LVQSLEECTK LPEAQQRVGG CFLNLMPQMK TLYLTYCANH PSAVNVLTEH
210 220 230 240 250
SEELGEFMET KGASSPGILV LTTGLSKPFM RLDKYPTLLK ELERHMEDYH
260 270 280 290 300
TDRQDIQKSM AAFKNLSAQC QEVRKRKELE LQILTEAIRN WEGDDIKTLG
310 320 330 340 350
NVTYMSQVLI QCAGSEEKNE RYLLLFPNVL LMLSASPRMS GFIYQGKLPT
360 370 380 390 400
TGMTITKLED SENHRNAFEI SGSMIERILV SCNNQQDLQE WVEHLQKQTK
410 420 430 440 450
VTSVGNPTIK PHSVPSHTLP SHPVTPSSKH ADSKPAPLTP AYHTLPHPSH
460 470 480 490 500
HGTPHTTINW GPLEPPKTPK PWSLSCLRPA PPLRPSAALC YKEDLSKSPK
510 520 530 540 550
TMKKLLPKRK PERKPSDEEF ASRKSTAALE EDAQILKVIE AYCTSAKTRQ
560 570 580 590 600
TLNSTWQGTD LMHNHVLADD DQPSLDSLGR RSSLSRLEPS DLSEDSDYDS
610 620 630 640 650
IWTAHSYRMG STSRSRKESA PQVLLPEEEK IIVEETKSNG QTVIEEKSLV
660 670 680 690 700
DTVYALKDEV QELRQDNKKM KKSLEEEQRA RKDLEKLVRK VLKNMNDPAW

DETNL
Length:705
Mass (Da):79,832
Last modified:April 8, 2008 - v1
Checksum:i5A1E4E9A3437AD94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139086 Genomic DNA No translation available.
AL353704 Genomic DNA No translation available.
AL390754 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000218789; ENSP00000218789; ENSG00000102606
UCSCiuc058yii.1 human

Similar proteinsi

Entry informationi

Entry nameiB1ALK7_HUMAN
AccessioniPrimary (citable) accession number: B1ALK7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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