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Protein

Kinesin-like protein

Gene

KIF12

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor proteinUniRule annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like proteinUniRule annotation
Gene namesi
Name:KIF12Imported
ORF Names:hCG_32518Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136883.12
HGNCiHGNC:21495 KIF12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MicrotubuleUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136883
PharmGKBiPA134931618

Expressioni

Gene expression databases

BgeeiENSG00000136883

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 227Kinesin motorInterPro annotationAdd BLAST227

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili249 – 269Sequence analysisAdd BLAST21
Coiled coili289 – 330Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000144010
HOGENOMiHOG000049053
HOVERGENiHBG052248
KOiK10399
OMAiERSHSDW
OrthoDBiEOG091G0SNP
TreeFamiTF324584

Family and domain databases

Gene3Di3.40.850.101 hit
InterProiView protein in InterPro
IPR028763 Kif12
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PTHR24115:SF418 PTHR24115:SF418, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

B1ALC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRTFAWLLD RVQHLGAPVT LRASYLEIYN EQVRDLLSLG SPRPLPVRWN
60 70 80 90 100
KTRGFYVEQL RVVEFGSLEA LMELLQTGLS RRRNSAHTLN QASSRSHALL
110 120 130 140 150
TLYISRQTAQ QMPSVDPGEP PVGGKLCFVD LAGSEKVAAT GSRGELMLEA
160 170 180 190 200
NSINRSLLAL GHCISLLLDP QRKQSHIPFR DSKLTKLLAD SLGGRGVTLM
210 220 230 240 250
VACVSPSAQC LPETLSTLRY ASRAQRVTTR PQAPKSPVAK QPQRLETEML
260 270 280 290 300
QLQEENRRLQ FQLDQMDCKA SGLSGARVAW AQRNLYGMLQ EFMLENERLR
310 320 330 340 350
KEKSQLQNSR DLAQNEQRIL AQQVHALERR LLSACYHHQQ GPGLTPPCPC
360 370 380 390 400
LMAPAPPCHA LPPLYSCPCC HICPLCRVPL AHWACLPGEH HLPQVLDPEA
410 420 430 440 450
SGGRPPSARP PPWAPPCSPG SAKCPRERSH SDWTQTRVLA EMLTEEEVVP
460 470 480 490 500
SAPPLPVRPP KTSPGLRGGA GVPNLAQRLE ALRDQIGSSL RRGRSQPPCS
510
EGARSPGQVL PPH
Length:513
Mass (Da):56,627
Last modified:April 8, 2008 - v1
Checksum:i696DB753C0966563
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137850 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87407.1
RefSeqiNP_612433.1, NM_138424.1
UniGeneiHs.28149

Genome annotation databases

EnsembliENST00000374118; ENSP00000363232; ENSG00000136883
GeneIDi113220
KEGGihsa:113220
UCSCiuc004bif.3 human

Similar proteinsi

Entry informationi

Entry nameiB1ALC3_HUMAN
AccessioniPrimary (citable) accession number: B1ALC3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported