B1AKP8 (B1AKP8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Serine/threonine-protein kinase mTOR Ensembl ENSP00000366034

Gene names

Name:

MTOR Ensembl ENSP00000366034

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000366034

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	754 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 FAT domain. SAAS SAAS018936 Contains 1 FATC domain. SAAS SAAS018936 Contains 1 PI3K/PI4K domain. SAAS SAAS018936
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000366034

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS018936 Nucleotide-binding
Molecular function	Kinase SAAS SAAS018936 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to hypoxia Inferred from electronic annotation. Source: Compara cellular response to nutrient levels Inferred from electronic annotation. Source: Compara germ cell development Inferred from electronic annotation. Source: Compara negative regulation of NFAT protein import into nucleus Inferred from electronic annotation. Source: Compara negative regulation of cell size Inferred from electronic annotation. Source: Compara negative regulation of macroautophagy Inferred from electronic annotation. Source: Compara peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara peptidyl-threonine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of actin filament polymerization Inferred from electronic annotation. Source: Compara positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of lamellipodium assembly Inferred from electronic annotation. Source: Compara positive regulation of myotube differentiation Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara positive regulation of stress fiber assembly Inferred from electronic annotation. Source: Compara positive regulation of translation Inferred from electronic annotation. Source: Compara protein autophosphorylation Inferred from electronic annotation. Source: Compara regulation of Rac GTPase activity Inferred from electronic annotation. Source: Compara regulation of carbohydrate utilization Inferred from electronic annotation. Source: Compara regulation of fatty acid beta-oxidation Inferred from electronic annotation. Source: Compara regulation of glycogen biosynthetic process Inferred from electronic annotation. Source: Compara regulation of protein kinase activity Inferred from electronic annotation. Source: Compara regulation of response to food Inferred from electronic annotation. Source: Compara response to amino acid stimulus Inferred from electronic annotation. Source: Compara response to insulin stimulus Inferred from electronic annotation. Source: Compara ruffle organization Inferred from electronic annotation. Source: Compara
Cellular_component	PML body Inferred from electronic annotation. Source: Compara TORC1 complex Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara mTOR-FKBP12-rapamycin complex Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW drug binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: Compara ribosome binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1AKP8 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 0AC837B2544A1CEA	FASTA	754	85,901
	10 20 30 40 50 60 MNFEAVLHYK HQNQARDEKK KLRHASGANI TNATTAATTA ATATTTASTE GSNSESEAES 70 80 90 100 110 120 TENSPTPSPL QKKVTEDLSK TLLMYTVPAV QGFFRSISLS RGNNLQDTLR VLTLWFDYGH 130 140 150 160 170 180 WPDVNEALVE GVKAIQIDTW LQVIPQLIAR IDTPRPLVGR LIHQLLTDIG RYHPQALIYP 190 200 210 220 230 240 LTVASKSTTT ARHNAANKIL KNMCEHSNTL VQQAMMVSEE LIRVAILWHE MWHEGLEEAS 250 260 270 280 290 300 RLYFGERNVK GMFEVLEPLH AMMERGPQTL KETSFNQAYG RDLMEAQEWC RKYMKSGNVK 310 320 330 340 350 360 DLTQAWDLYY HVFRRISKQL PQLTSLELQY VSPKLLMCRD LELAVPGTYD PNQPIIRIQS 370 380 390 400 410 420 IAPSLQVITS KQRPRKLTLM GSNGHEFVFL LKGHEDLRQD ERVMQLFGLV NTLLANDPTS 430 440 450 460 470 480 LRKNLSIQRY AVIPLSTNSG LIGWVPHCDT LHALIRDYRE KKKILLNIEH RIMLRMAPDY 490 500 510 520 530 540 DHLTLMQKVE VFEHAVNNTA GDDLAKLLWL KSPSSEVWFD RRTNYTRSLA VMSMVGYILG 550 560 570 580 590 600 LGDRHPSNLM LDRLSGKILH IDFGDCFEVA MTREKFPEKI PFRLTRMLTN AMEVTGLDGN 610 620 630 640 650 660 YRITCHTVME VLREHKDSVM AVLEAFVYDP LLNWRLMDTN TKGNKRSRTR TDSYSAGQSV 670 680 690 700 710 720 EILDGVELGE PAHKKTGTTV PESIHSFIGD GLVKPEALNK KAIQIINRVR DKLTGRDFSH 730 740 750 DDTLDVPTQV ELLIKQATSH ENLCQCYIGW CPFW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL049653 Genomic DNA. No translation available. AL109811 Genomic DNA. No translation available. AL391561 Genomic DNA. No translation available.
IPI	IPI00643451.
UniGene	Hs.338207.
3D structure databases
ProteinModelPortal	B1AKP8.
SMR	B1AKP8. Positions 224-317, 345-627, 722-754.
ModBase	Search...
Proteomic databases
PRIDE	B1AKP8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376838; ENSP00000366034; ENSG00000198793.
UCSC	uc001asc.3. human.
Organism-specific databases
HGNC	HGNC:3942. MTOR.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000049044.
HOVERGEN	HBG102007.
Gene expression databases
ArrayExpress	B1AKP8.
Family and domain databases
Gene3D	1.10.1070.11. 3 hits.
InterPro	IPR003152. FATC. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat_dom. IPR018936. PI3/4_kinase_CS. IPR003151. PIK-rel_kinase_FAT. IPR014009. PIK_FAT. IPR009076. Rapamycin-bd_dom. IPR026683. TOR/Smg1. [Graphical view]
PANTHER	PTHR11139:SF9. PTHR11139:SF9. 1 hit.
Pfam	PF02259. FAT. 1 hit. PF02260. FATC. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. PF08771. Rapamycin_bind. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF47212. FRAP_FKBP12_bind. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS51189. FAT. 1 hit. PS51190. FATC. 1 hit. PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MTOR. human.
NextBio	35466581.

Entry information

Entry name

B1AKP8_HUMAN

Accession

Primary (citable) accession number: B1AKP8

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.