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Protein
Submitted name:

Nardilysin

Gene

NRDC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM16.987.

Names & Taxonomyi

Protein namesi
Submitted name:
NardilysinImported
Submitted name:
Nardilysin (N-arginine dibasic convertase), isoform CRA_dImported
Gene namesi
Name:NRDCImported
Synonyms:NRD1Imported
ORF Names:hCG_40292Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7995. NRDC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31774.

PTM / Processingi

Proteomic databases

EPDiB1AKJ5.

Expressioni

Gene expression databases

BgeeiENSG00000078618.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346890.

Structurei

3D structure databases

SMRiB1AKJ5. Positions 279-1157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini277 – 404128Peptidase_M16InterPro annotationAdd
BLAST
Domaini431 – 615185Peptidase_M16_CInterPro annotationAdd
BLAST
Domaini621 – 902282Peptidase_M16_MInterPro annotationAdd
BLAST
Domaini907 – 1088182Peptidase_M16_CInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili179 – 21335Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0959. Eukaryota.
COG1025. LUCA.
GeneTreeiENSGT00530000063327.
HOGENOMiHOG000231160.
HOVERGENiHBG006530.
OMAiIENSWAE.
OrthoDBiEOG091G0255.
PhylomeDBiB1AKJ5.
TreeFamiTF106274.

Family and domain databases

Gene3Di3.30.830.10. 5 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
IPR032632. Peptidase_M16_M.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 2 hits.
PF16187. Peptidase_M16_M. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 4 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AKJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRVTVAAV CATRRKLCEA GRELAALWGI ETRGRCEDSA AARPFPILAM
60 70 80 90 100
PGRNKAKSTC SCPDLQPNGQ DLGENSRVAR LGADESEEEG RRGSLSNAGD
110 120 130 140 150
PEIVKSPSDP KQYRYIKLQN GLQALLISDL SNMEGKTGNT TDDEEEEEVE
160 170 180 190 200
EEEEDDDEDS GAEIEDDDEE GFDDEDEFDD EHDDDLDTED NELEELEERA
210 220 230 240 250
EARKKTTEKQ QLQSLFLLWS KLTDRLWFKS TYSKMSSTLL VETRNLYGVV
260 270 280 290 300
GAESRSAPVQ HLAGWQAEEQ QGETDTVLSA AALCVGVGSF ADPDDLPGLA
310 320 330 340 350
HFLEHMVFMG SLKYPDENGF DAFLKKHGGS DNASTDCERT VFQFDVQRKY
360 370 380 390 400
FKEALDRWAQ FFIHPLMIRD AIDREVEAVD SEYQLARPSD ANRKEMLFGS
410 420 430 440 450
LARPGHPMGK FFWGNAETLK HEPRKNNIDT HARLREFWMR YYSSHYMTLV
460 470 480 490 500
VQSKETLDTL EKWVTEIFSQ IPNNGLPRPN FGHLTDPFDT PAFNKLYRVV
510 520 530 540 550
PIRKIHALTI TWALPPQQQH YRVKPLHYIS WLVGHEGKGS ILSFLRKKCW
560 570 580 590 600
ALALFGGNGE TGFEQNSTYS VFSISITLTD EGYEHFYEVA YTVFQYLKML
610 620 630 640 650
QKLGPEKRIF EEIRKIEDNE FHYQEQTDPV EYVENMCENM QLYPLQDILT
660 670 680 690 700
GDQLLFEYKP EVIGEALNQL VPQKANLVLL SGANEGKCDL KEKWFGTQYS
710 720 730 740 750
IEDIENSWAE LWNSNFELNP DLHLPAENKY IATDFTLKAF DCPETEYPVK
760 770 780 790 800
IVNTPQGCLW YKKDNKFKIP KAYIRFHLIS PLIQKSAANV VLFDIFVNIL
810 820 830 840 850
THNLAEPAYE ADVAQLEYKL VAGEHGLIIR VKGFNHKLPL LFQLIIDYLA
860 870 880 890 900
EFNSTPAVFT MITEQLKKTY FNILIKPETL AKDVRLLILE YARWSMIDKY
910 920 930 940 950
QALMDGLSLE SLLSFVKEFK SQLFVEGLVQ GNVTSTESMD FLKYVVDKLN
960 970 980 990 1000
FKPLEQEMPV QFQVVELPSG HHLCKVKALN KGDANSEVTV YYQSGTRSLR
1010 1020 1030 1040 1050
EYTLMELLVM HMEEPCFDFL RTKQTLGYHV YPTCRNTSGI LGFSVTVGTQ
1060 1070 1080 1090 1100
ATKYNSEVVD KKIEEFLSSF EEKIENLTEE AFNTQVTALI KLKECEDTHL
1110 1120 1130 1140 1150
GEEVDRNWNE VVTQQYLFDR LAHEIEALKS FSKSDLVNWF KAHRGPGSKM
1160 1170 1180 1190 1200
LSVHVVGYGK YELEEDGTPS SEDSNSSCEV MQLTYLPTSP LLADCIIPIT
1210
DIRAFTTTLN LLPYHKIVK
Length:1,219
Mass (Da):139,413
Last modified:April 8, 2008 - v1
Checksum:i4E41D50112DB4070
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050343 Genomic DNA. No translation available.
AL589663 Genomic DNA. No translation available.
KF495940 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06807.1.
RefSeqiNP_002516.2. NM_002525.2.
UniGeneiHs.584782.

Genome annotation databases

EnsembliENST00000354831; ENSP00000346890; ENSG00000078618.
GeneIDi4898.
UCSCiuc001ctc.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050343 Genomic DNA. No translation available.
AL589663 Genomic DNA. No translation available.
KF495940 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06807.1.
RefSeqiNP_002516.2. NM_002525.2.
UniGeneiHs.584782.

3D structure databases

SMRiB1AKJ5. Positions 279-1157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000346890.

Protein family/group databases

MEROPSiM16.987.

Proteomic databases

EPDiB1AKJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354831; ENSP00000346890; ENSG00000078618.
GeneIDi4898.
UCSCiuc001ctc.5. human.

Organism-specific databases

CTDi4898.
HGNCiHGNC:7995. NRDC.
PharmGKBiPA31774.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0959. Eukaryota.
COG1025. LUCA.
GeneTreeiENSGT00530000063327.
HOGENOMiHOG000231160.
HOVERGENiHBG006530.
OMAiIENSWAE.
OrthoDBiEOG091G0255.
PhylomeDBiB1AKJ5.
TreeFamiTF106274.

Miscellaneous databases

ChiTaRSiNRD1. human.
GenomeRNAii4898.

Gene expression databases

BgeeiENSG00000078618.

Family and domain databases

Gene3Di3.30.830.10. 5 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
IPR032632. Peptidase_M16_M.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 2 hits.
PF16187. Peptidase_M16_M. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 4 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB1AKJ5_HUMAN
AccessioniPrimary (citable) accession number: B1AKJ5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.