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Protein
Submitted name:

Nardilysin

Gene

NRDC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Protein family/group databases

MEROPSiM16.987

Names & Taxonomyi

Protein namesi
Submitted name:
NardilysinImported
Submitted name:
Nardilysin (N-arginine dibasic convertase), isoform CRA_dImported
Gene namesi
Name:NRDCImported
Synonyms:NRD1Imported
ORF Names:hCG_40292Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000078618.19
HGNCiHGNC:7995 NRDC

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000078618
PharmGKBiPA31774

Expressioni

Gene expression databases

BgeeiENSG00000078618

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 404Peptidase_M16InterPro annotationAdd BLAST128
Domaini431 – 615Peptidase_M16_CInterPro annotationAdd BLAST185
Domaini621 – 902Peptidase_M16_MInterPro annotationAdd BLAST282
Domaini907 – 1088Peptidase_M16_CInterPro annotationAdd BLAST182

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili179 – 213Sequence analysisAdd BLAST35
Coiled coili1060 – 1080Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0959 Eukaryota
COG1025 LUCA
GeneTreeiENSGT00530000063327
HOGENOMiHOG000231160
HOVERGENiHBG006530
OMAiFAKFSVG
OrthoDBiEOG091G0255
TreeFamiTF106274

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
IPR032632 Peptidase_M16_M
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 2 hits
PF16187 Peptidase_M16_M, 1 hit
SUPFAMiSSF63411 SSF63411, 4 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

Sequencei

Sequence statusi: Complete.

B1AKJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRVTVAAV CATRRKLCEA GRELAALWGI ETRGRCEDSA AARPFPILAM
60 70 80 90 100
PGRNKAKSTC SCPDLQPNGQ DLGENSRVAR LGADESEEEG RRGSLSNAGD
110 120 130 140 150
PEIVKSPSDP KQYRYIKLQN GLQALLISDL SNMEGKTGNT TDDEEEEEVE
160 170 180 190 200
EEEEDDDEDS GAEIEDDDEE GFDDEDEFDD EHDDDLDTED NELEELEERA
210 220 230 240 250
EARKKTTEKQ QLQSLFLLWS KLTDRLWFKS TYSKMSSTLL VETRNLYGVV
260 270 280 290 300
GAESRSAPVQ HLAGWQAEEQ QGETDTVLSA AALCVGVGSF ADPDDLPGLA
310 320 330 340 350
HFLEHMVFMG SLKYPDENGF DAFLKKHGGS DNASTDCERT VFQFDVQRKY
360 370 380 390 400
FKEALDRWAQ FFIHPLMIRD AIDREVEAVD SEYQLARPSD ANRKEMLFGS
410 420 430 440 450
LARPGHPMGK FFWGNAETLK HEPRKNNIDT HARLREFWMR YYSSHYMTLV
460 470 480 490 500
VQSKETLDTL EKWVTEIFSQ IPNNGLPRPN FGHLTDPFDT PAFNKLYRVV
510 520 530 540 550
PIRKIHALTI TWALPPQQQH YRVKPLHYIS WLVGHEGKGS ILSFLRKKCW
560 570 580 590 600
ALALFGGNGE TGFEQNSTYS VFSISITLTD EGYEHFYEVA YTVFQYLKML
610 620 630 640 650
QKLGPEKRIF EEIRKIEDNE FHYQEQTDPV EYVENMCENM QLYPLQDILT
660 670 680 690 700
GDQLLFEYKP EVIGEALNQL VPQKANLVLL SGANEGKCDL KEKWFGTQYS
710 720 730 740 750
IEDIENSWAE LWNSNFELNP DLHLPAENKY IATDFTLKAF DCPETEYPVK
760 770 780 790 800
IVNTPQGCLW YKKDNKFKIP KAYIRFHLIS PLIQKSAANV VLFDIFVNIL
810 820 830 840 850
THNLAEPAYE ADVAQLEYKL VAGEHGLIIR VKGFNHKLPL LFQLIIDYLA
860 870 880 890 900
EFNSTPAVFT MITEQLKKTY FNILIKPETL AKDVRLLILE YARWSMIDKY
910 920 930 940 950
QALMDGLSLE SLLSFVKEFK SQLFVEGLVQ GNVTSTESMD FLKYVVDKLN
960 970 980 990 1000
FKPLEQEMPV QFQVVELPSG HHLCKVKALN KGDANSEVTV YYQSGTRSLR
1010 1020 1030 1040 1050
EYTLMELLVM HMEEPCFDFL RTKQTLGYHV YPTCRNTSGI LGFSVTVGTQ
1060 1070 1080 1090 1100
ATKYNSEVVD KKIEEFLSSF EEKIENLTEE AFNTQVTALI KLKECEDTHL
1110 1120 1130 1140 1150
GEEVDRNWNE VVTQQYLFDR LAHEIEALKS FSKSDLVNWF KAHRGPGSKM
1160 1170 1180 1190 1200
LSVHVVGYGK YELEEDGTPS SEDSNSSCEV MQLTYLPTSP LLADCIIPIT
1210
DIRAFTTTLN LLPYHKIVK
Length:1,219
Mass (Da):139,413
Last modified:April 8, 2008 - v1
Checksum:i4E41D50112DB4070
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050343 Genomic DNA No translation available.
AL589663 Genomic DNA No translation available.
KF495940 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06807.1
RefSeqiNP_002516.2, NM_002525.2
UniGeneiHs.584782

Genome annotation databases

EnsembliENST00000354831; ENSP00000346890; ENSG00000078618
GeneIDi4898
UCSCiuc001ctc.5 human

Similar proteinsi

Entry informationi

Entry nameiB1AKJ5_HUMAN
AccessioniPrimary (citable) accession number: B1AKJ5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health