ID   B1AK73_HUMAN            Unreviewed;       205 AA.
AC   B1AK73;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 2.
DT   27-MAR-2024, entry version 103.
DE   SubName: Full=Phospholipase C beta 1 {ECO:0000313|Ensembl:ENSP00000384001.3};
GN   Name=PLCB1 {ECO:0000313|Ensembl:ENSP00000384001.3};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000384001.3, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000384001.3, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000384001.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AL021396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL021406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL050323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF510482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; B1AK73; -.
DR   SMR; B1AK73; -.
DR   MassIVE; B1AK73; -.
DR   PeptideAtlas; B1AK73; -.
DR   ProteomicsDB; 3024; -.
DR   Antibodypedia; 3795; 319 antibodies from 36 providers.
DR   Ensembl; ENST00000404098.6; ENSP00000384001.3; ENSG00000182621.19.
DR   UCSC; uc010gbv.3; human.
DR   HGNC; HGNC:15917; PLCB1.
DR   VEuPathDB; HostDB:ENSG00000182621; -.
DR   GeneTree; ENSGT00940000155428; -.
DR   HOGENOM; CLU_1337126_0_0_1; -.
DR   ChiTaRS; PLCB1; human.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000182621; Expressed in endothelial cell and 197 other cell types or tissues.
DR   ExpressionAtlas; B1AK73; baseline and differential.
DR   CDD; cd13361; PH_PLC_beta; 1.
DR   Gene3D; 2.30.29.240; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR037862; PLC-beta_PH.
DR   Pfam; PF17787; PH_14; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:B1AK73,
KW   ECO:0007829|MaxQB:B1AK73};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          18..145
FT                   /note="PLC-beta PH"
FT                   /evidence="ECO:0000259|Pfam:PF17787"
SQ   SEQUENCE   205 AA;  23137 MW;  99BC00A54A3C0969 CRC64;
     MAGAQPGVHA LQLKPVCVSD SLKKGTKFVK WDDDSTIVTP IILRTDPQGF FFYWTDQNKE
     TELLDLSLVK DARCGRHAKA PKDPKLRELL DVGNIGRLEQ RMITVVYGPD LVNISHLNLV
     AFQEEVAKEW TNEVFSLATN LLAQNMSRDA FLEKAYTKLK LQVTPEGRIP LKNIYRLFSA
     DRKRVETALE ACSLPSSRVS MCVML
//