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Protein
Submitted name:

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Gene

PLCB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. phosphatidylinositol phospholipase C activity Source: InterPro

GO - Biological processi

  1. brain development Source: InterPro
  2. intracellular signal transduction Source: InterPro
  3. regulation of cell cycle Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1Imported
Gene namesi
Name:PLCB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15917. PLCB1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
  2. nucleus Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiB1AK73. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliB1AK73.
SMRiB1AK73. Positions 11-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118936.
HOGENOMiHOG000200010.
HOVERGENiHBG075740.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028400. PLC-beta1.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF12. PTHR10336:SF12. 1 hit.

Sequencei

Sequence statusi: Fragment.

B1AK73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AGAQPGVHAL QLKPVCVSDS LKKGTKFVKW DDDSTIVTPI ILRTDPQGFF
60 70 80 90 100
FYWTDQNKET ELLDLSLVKD ARCGRHAKAP KDPKLRELLD VGNIGRLEQR
110 120 130 140 150
MITVVYGPDL VNISHLNLVA FQEEVAKEWT NEVFSLATNL LAQNMSRDAF
160 170 180 190 200
LEKAYTKLKL QVTPEGRIPL KNIYRLFSAD RKRVETALEA CSLPSSRVEK
210 220 230
ANEAAKSEQS CGKAPPKHFH LHFIKQNKML EP
Length:232
Mass (Da):26,197
Last modified:April 8, 2008 - v1
Checksum:i14337144027AEFD9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei232 – 2321Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021406 Genomic DNA. No translation available.
AL031655 Genomic DNA. No translation available.
AL031683 Genomic DNA. No translation available.
AL034551 Genomic DNA. No translation available.
AL049593 Genomic DNA. No translation available.
AL049632 Genomic DNA. No translation available.
AL050315 Genomic DNA. No translation available.
AL050319 Genomic DNA. No translation available.
AL050323 Genomic DNA. No translation available.
AL121589 Genomic DNA. No translation available.
AL365212 Genomic DNA. No translation available.
AL445567 Genomic DNA. No translation available.
KF456806 Genomic DNA. No translation available.
KF456807 Genomic DNA. No translation available.
KF456810 Genomic DNA. No translation available.
KF456814 Genomic DNA. No translation available.
KF456816 Genomic DNA. No translation available.
KF510482 Genomic DNA. No translation available.
KF511324 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000404098; ENSP00000384001; ENSG00000182621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021406 Genomic DNA. No translation available.
AL031655 Genomic DNA. No translation available.
AL031683 Genomic DNA. No translation available.
AL034551 Genomic DNA. No translation available.
AL049593 Genomic DNA. No translation available.
AL049632 Genomic DNA. No translation available.
AL050315 Genomic DNA. No translation available.
AL050319 Genomic DNA. No translation available.
AL050323 Genomic DNA. No translation available.
AL121589 Genomic DNA. No translation available.
AL365212 Genomic DNA. No translation available.
AL445567 Genomic DNA. No translation available.
KF456806 Genomic DNA. No translation available.
KF456807 Genomic DNA. No translation available.
KF456810 Genomic DNA. No translation available.
KF456814 Genomic DNA. No translation available.
KF456816 Genomic DNA. No translation available.
KF510482 Genomic DNA. No translation available.
KF511324 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB1AK73.
SMRiB1AK73. Positions 11-205.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiB1AK73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000404098; ENSP00000384001; ENSG00000182621.

Organism-specific databases

HGNCiHGNC:15917. PLCB1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118936.
HOGENOMiHOG000200010.
HOVERGENiHBG075740.

Miscellaneous databases

ChiTaRSiPLCB1. human.
NextBioi35466511.

Gene expression databases

ExpressionAtlasiB1AK73. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028400. PLC-beta1.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF12. PTHR10336:SF12. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB1AK73_HUMAN
AccessioniPrimary (citable) accession number: B1AK73
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: March 4, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationMaxQB annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.