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Protein

Forkhead-associated domain-containing protein 1

Gene

FHAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead-associated domain-containing protein 1
Short name:
FHA domain-containing protein 1
Gene namesi
Name:FHAD1
Synonyms:KIAA1937
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29408. FHAD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671762.

Polymorphism and mutation databases

BioMutaiFHAD1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14121412Forkhead-associated domain-containing protein 1PRO_0000349365Add
BLAST

Proteomic databases

EPDiB1AJZ9.
MaxQBiB1AJZ9.
PaxDbiB1AJZ9.
PRIDEiB1AJZ9.

PTM databases

iPTMnetiB1AJZ9.
PhosphoSiteiB1AJZ9.

Expressioni

Gene expression databases

BgeeiB1AJZ9.
CleanExiHS_FHAD1.
ExpressionAtlasiB1AJZ9. baseline and differential.
GenevisibleiB1AJZ9. HS.

Organism-specific databases

HPAiHPA054284.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365167.

Structurei

3D structure databases

ProteinModelPortaliB1AJZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 6952FHAPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili250 – 466217Sequence analysisAdd
BLAST
Coiled coili692 – 963272Sequence analysisAdd
BLAST
Coiled coili999 – 1099101Sequence analysisAdd
BLAST
Coiled coili1141 – 116929Sequence analysisAdd
BLAST
Coiled coili1292 – 136069Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi98 – 16063Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 FHA domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEEP. Eukaryota.
ENOG4110M3I. LUCA.
GeneTreeiENSGT00520000056487.
HOGENOMiHOG000112586.
HOVERGENiHBG107918.
InParanoidiB1AJZ9.
OMAiMCDISVQ.
OrthoDBiEOG7C5M8B.
PhylomeDBiB1AJZ9.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B1AJZ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAYLKSAEG FFVLNKSTTI GRHENSDLVL QSPDIDNHHA LIEYNEAECS
60 70 80 90 100
FVLQDFNSRN GTFVNECHIQ NVAVKLIPGD ILRFGSAGLT YELVIENPPP
110 120 130 140 150
VSFPWMRGPA PWPGPQPPRA TQQPNQAPPP SHIPFHQGVQ PAPMQRSWSQ
160 170 180 190 200
AFPRPTVVLP ASHRRPVSAN KEMFSFVVDD ARKPPVIKQV WTNAMKLSEK
210 220 230 240 250
SVAEGIPGAV PPAEIYVEED LAQQDKDEII LLLGKEVSRL SDYEIESKYK
260 270 280 290 300
DVIIANLQNE VAELSQKVSE TTTSRQNEKE ISQKCQVLDE DIDAKQKEIQ
310 320 330 340 350
SLKSQISALQ KGYSKVLCQT LSERNSEITS LKNEGENLKR DNAITSGMVS
360 370 380 390 400
SLQKDILAKD EQVQQLKEEV SHLKSQNKDK DHQLEALGSR CSVLKEELKQ
410 420 430 440 450
EDAHRELREA QEKELKLCKT QIQDMEKEMK KLRAELRKSC TEQSVISRTL
460 470 480 490 500
REKSKVEEKL QEDSRRKLLQ LQEMGNRESV IKINLERAVG QLEHFRSQVI
510 520 530 540 550
KATYGRAKPF RDKPVTDQQL IEKITQVTED NINFQQKKWT LQKETQLSNS
560 570 580 590 600
KQEETTENIE KLRTSLDSCQ ACMKISCCSH DLKKEVDLLQ HLQVSPPVSG
610 620 630 640 650
LQKVVLDVLR HALSWLEEVE QLLRDLGILP SSPNKDQVQQ FSGNSAVFTA
660 670 680 690 700
GKAAGASGRE GEAERGEARA RGEAQSQNQA TDGREGGKAL EEYITQERNR
710 720 730 740 750
AKETLEEERK RMQELESLLA QQKKALAKSI TQEKNRVKEA LEEEQTRVQE
760 770 780 790 800
LEERLARQKE VLESSIAHEK RKAKEALESE KRKVQDLENH LTQQKEISES
810 820 830 840 850
NIAYEKRKAK EAMEKEKKKV QDLENRLTKQ KEELELKEQK EDVLNNKLSD
860 870 880 890 900
ALAMVEETQK TKATESLKAE SLALKLNETL AELETTKTKM IMVEERLILQ
910 920 930 940 950
QKMVKALQDE QESQRHGFEE EIMEYKEQIK QHAQTIVSLE EKLQKVTQHH
960 970 980 990 1000
KKIEGEIATL KDNDPAPKEE RPQDPLVAPM TESSAKDMAY EHLIDDLLAA
1010 1020 1030 1040 1050
QKEILSQQEV IMKLRKDLTE AHSRMSDLRG ELNEKQKMEL EQNVVLVQQQ
1060 1070 1080 1090 1100
SKELSVLKEK MAQMSSLVEK KDRELKALEE ALRASQEKHR LQLNTEKEQK
1110 1120 1130 1140 1150
PRKKTQTCDT SVQIEPVHTE AFSSSQEQQS FSDLGVRCKG SRHEEVIQRQ
1160 1170 1180 1190 1200
KKALSELRAR IKELEKARSP DHKDHQNESF LDLKNLRMEN NVQKILLDAK
1210 1220 1230 1240 1250
PDLPTLSRIE ILAPQNGLCN ARFGSAMEKS GKMDVAEALE LSEKLYLDMS
1260 1270 1280 1290 1300
KTLGSLMNIK NMSGHVSMKY LSRQEREKVN QLRQRDLDLV FDKITQLKNQ
1310 1320 1330 1340 1350
LGRKEELLRG YEKDVEQLRR SKVSIEMYQS QVAKLEDDIY KEAEEKALLK
1360 1370 1380 1390 1400
EALERMEHQL CQEKRINRAI RQQKVGTRKA SLKMDQEREM LRKETSSKSS
1410
QSLLHSKPSG KY
Length:1,412
Mass (Da):161,904
Last modified:September 2, 2008 - v2
Checksum:i03BE058D84CF65AA
GO
Isoform 3 (identifier: B1AJZ9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1375-1412: VGTRKASLKM...LLHSKPSGKY → MRKLRLRELR...PAPPACSLNG

Note: No experimental confirmation available.
Show »
Length:1,453
Mass (Da):166,300
Checksum:iD2777F2598E6BD7F
GO
Isoform 4 (identifier: B1AJZ9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     758-793: Missing.

Note: No experimental confirmation available.
Show »
Length:1,376
Mass (Da):157,691
Checksum:i97F5422E0F939403
GO

Sequence cautioni

The sequence BAC04126.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC04242.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC04913.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI21427.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI21811.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI23268.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1004 – 10041I → L in BAC04913 (PubMed:14702039).Curated
Sequence conflicti1366 – 13661I → V in BAC04913 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti763 – 7631E → K.
Corresponds to variant rs12126178 [ dbSNP | Ensembl ].
VAR_046372

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei758 – 79336Missing in isoform 4. 1 PublicationVSP_035366Add
BLAST
Alternative sequencei1375 – 141238VGTRK…PSGKY → MRKLRLRELRGAQVHTAAGK DSWDLTPDPSDPGSPAVCRV GRKCRGARTEKRKRIDTLQL CLQRERQAGPAPPACSLNG in isoform 3. 1 PublicationVSP_035369Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031283, AL158174, AL391094 Genomic DNA. Translation: CAI21427.1. Sequence problems.
AL158174, AL031283, AL391094 Genomic DNA. Translation: CAI21811.1. Sequence problems.
AL391094, AL031283, AL158174 Genomic DNA. Translation: CAI23268.1. Sequence problems.
AK093300 mRNA. Translation: BAC04126.1. Different initiation.
AK093883 mRNA. Translation: BAC04242.1. Different initiation.
AK096961 mRNA. Translation: BAC04913.1. Different initiation.
RefSeqiNP_443161.1. NM_052929.1. [B1AJZ9-1]
UniGeneiHs.659997.

Genome annotation databases

EnsembliENST00000358897; ENSP00000351770; ENSG00000142621. [B1AJZ9-1]
ENST00000375998; ENSP00000365166; ENSG00000142621. [B1AJZ9-1]
GeneIDi114827.
KEGGihsa:114827.
UCSCiuc001awb.2. human. [B1AJZ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031283, AL158174, AL391094 Genomic DNA. Translation: CAI21427.1. Sequence problems.
AL158174, AL031283, AL391094 Genomic DNA. Translation: CAI21811.1. Sequence problems.
AL391094, AL031283, AL158174 Genomic DNA. Translation: CAI23268.1. Sequence problems.
AK093300 mRNA. Translation: BAC04126.1. Different initiation.
AK093883 mRNA. Translation: BAC04242.1. Different initiation.
AK096961 mRNA. Translation: BAC04913.1. Different initiation.
RefSeqiNP_443161.1. NM_052929.1. [B1AJZ9-1]
UniGeneiHs.659997.

3D structure databases

ProteinModelPortaliB1AJZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365167.

PTM databases

iPTMnetiB1AJZ9.
PhosphoSiteiB1AJZ9.

Polymorphism and mutation databases

BioMutaiFHAD1.

Proteomic databases

EPDiB1AJZ9.
MaxQBiB1AJZ9.
PaxDbiB1AJZ9.
PRIDEiB1AJZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358897; ENSP00000351770; ENSG00000142621. [B1AJZ9-1]
ENST00000375998; ENSP00000365166; ENSG00000142621. [B1AJZ9-1]
GeneIDi114827.
KEGGihsa:114827.
UCSCiuc001awb.2. human. [B1AJZ9-1]

Organism-specific databases

CTDi114827.
GeneCardsiFHAD1.
HGNCiHGNC:29408. FHAD1.
HPAiHPA054284.
neXtProtiNX_B1AJZ9.
PharmGKBiPA142671762.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEEP. Eukaryota.
ENOG4110M3I. LUCA.
GeneTreeiENSGT00520000056487.
HOGENOMiHOG000112586.
HOVERGENiHBG107918.
InParanoidiB1AJZ9.
OMAiMCDISVQ.
OrthoDBiEOG7C5M8B.
PhylomeDBiB1AJZ9.

Miscellaneous databases

ChiTaRSiFHAD1. human.
GenomeRNAii114827.
PROiB1AJZ9.

Gene expression databases

BgeeiB1AJZ9.
CleanExiHS_FHAD1.
ExpressionAtlasiB1AJZ9. baseline and differential.
GenevisibleiB1AJZ9. HS.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
InterProiIPR000253. FHA_dom.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF00498. FHA. 1 hit.
[Graphical view]
SMARTiSM00240. FHA. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
PROSITEiPS50006. FHA_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 299-768 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 730-1412 (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 985-1412 (ISOFORM 3).
    Tissue: Small intestine, Testis and Trachea.

Entry informationi

Entry nameiFHAD1_HUMAN
AccessioniPrimary (citable) accession number: B1AJZ9
Secondary accession number(s): Q0P6F5
, Q8N8D3, Q8N9T6, Q8NA05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 8, 2016
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.