UniProtKB - B1AJZ6 (B1AJZ6_HUMAN)
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Protein
Protein Wnt
Gene
WNT4
Organism
Homo sapiens (Human)
Status
Functioni
Ligand for members of the frizzled family of seven transmembrane receptors.UniRule annotation
GO - Molecular functioni
- receptor binding Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
| Molecular function | Developmental proteinUniRule annotation |
| Biological process | Wnt signaling pathwayUniRule annotation |
Names & Taxonomyi
| Protein namesi | Recommended name: Protein WntUniRule annotation |
| Gene namesi | Name:WNT4Imported |
| Organismi | Homo sapiens (Human)Imported |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| HGNCi | HGNC:12783. WNT4. |
Subcellular locationi
- Secreted › extracellular space › extracellular matrix UniRule annotation
GO - Cellular componenti
- proteinaceous extracellular matrix Source: UniProtKB-SubCell
Expressioni
Gene expression databases
| Bgeei | ENSG00000162552. |
| ExpressionAtlasi | B1AJZ6. baseline and differential. |
Family & Domainsi
Sequence similaritiesi
Belongs to the Wnt family.UniRule annotation
Phylogenomic databases
| eggNOGi | KOG3913. Eukaryota. ENOG410XQZ1. LUCA. |
| GeneTreei | ENSGT00760000118943. |
Family and domain databases
| InterProi | View protein in InterPro IPR005817. Wnt. IPR009142. Wnt4. |
| PANTHERi | PTHR12027. PTHR12027. 1 hit. |
| Pfami | View protein in Pfam PF00110. wnt. 1 hit. |
| PRINTSi | PR01844. WNT4PROTEIN. |
Sequencei
Sequence statusi: Fragment.
B1AJZ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCKRNLEVMD SVRRGAQLAI EECQYQFRNR RWNCSTLDSL PVFGKVVTQG
GK
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Non-terminal residuei | 52 | Imported | 1 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031281 Genomic DNA. No translation available. AL445253 Genomic DNA. No translation available. |
Genome annotation databases
| Ensembli | ENST00000441048; ENSP00000388925; ENSG00000162552. |
| UCSCi | uc057ddr.1. human. |
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | B1AJZ6_HUMAN | |
| Accessioni | B1AJZ6Primary (citable) accession number: B1AJZ6 | |
| Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
| Last sequence update: | April 8, 2008 | |
| Last modified: | July 5, 2017 | |
| This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Caution
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported