WNT4

Functionⁱ

Ligand for members of the frizzled family of seven transmembrane receptors.UniRule annotation

GO - Molecular functionⁱ

receptor binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development Source: UniProtKB-KW
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental proteinUniRule annotation
Biological process	Wnt signaling pathwayUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein WntUniRule annotation
Gene namesⁱ	Name:WNT4Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162552.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12783 WNT4

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000162552

OpenTargetsⁱ

ENSG00000162552

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	B1AJZ6

PeptideAtlasⁱ

B1AJZ6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000162552
ExpressionAtlasⁱ	B1AJZ6 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

receptor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B1AJZ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Wnt family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3913 Eukaryota ENOG410XQZ1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118943

Family and domain databases

InterProⁱ	View protein in InterPro IPR005817 Wnt IPR009142 Wnt4
PANTHERⁱ	PTHR12027 PTHR12027, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00110 wnt, 1 hit
PRINTSⁱ	PR01844 WNT4PROTEIN

Sequenceⁱ

Sequence statusⁱ: Fragment.

B1AJZ6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MCKRNLEVMD SVRRGAQLAI EECQYQFRNR RWNCSTLDSL PVFGKVVTQG 

GK

Length:52

Mass (Da):6,020

Last modified:April 8, 2008 - v1

Checksum:ⁱ5F2B69EB0E3A6568

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	52	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL031281 Genomic DNA No translation available. AL445253 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL031281 Genomic DNA No translation available.
AL445253 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000441048; ENSP00000388925; ENSG00000162552
UCSC genome browser More...UCSCⁱ	uc057ddr.1 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B1AJZ6	A0A2J8T2R7 A0A2J8K4A7 UPI0005CFF8B4	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Homo sapiens (Human)	52	UniRef100_B1AJZ6	Cluster: Protein Wnt (Fragment)	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B1AJZ6	A0A2J8T2R7 A0A2J8K4A7 UPI0005CFF8B4	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Homo sapiens (Human)	52	UniRef90_B1AJZ6	Cluster: Protein Wnt (Fragment)	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B1AJZ6	K7EE05 UPI000454882B A0A2J8T2R7 A0A2J8K4A7 UPI0005CFF8B4	Ornithorhynchus anatinus (Duckbill platypus) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Homo sapiens (Human)	176	UniRef50_K7EE05	Cluster: Protein Wnt	6

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL031281 Genomic DNA No translation available. AL445253 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL031281 Genomic DNA No translation available.
AL445253 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	B1AJZ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	B1AJZ6

PeptideAtlasⁱ

B1AJZ6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000441048; ENSP00000388925; ENSG00000162552
UCSC genome browser More...UCSCⁱ	uc057ddr.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162552.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12783 WNT4
Open Targets More...OpenTargetsⁱ	ENSG00000162552
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3913 Eukaryota ENOG410XQZ1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118943

Miscellaneous databases

ChiTaRSⁱ	WNT4 human

ChiTaRSⁱ

WNT4 human

Gene expression databases

Bgeeⁱ	ENSG00000162552
ExpressionAtlasⁱ	B1AJZ6 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR005817 Wnt IPR009142 Wnt4
PANTHERⁱ	PTHR12027 PTHR12027, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00110 wnt, 1 hit
PRINTSⁱ	PR01844 WNT4PROTEIN
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B1AJZ6_HUMAN
Accessionⁱ	B1AJZ6Primary (citable) accession number: B1AJZ6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 8, 2008
	Last sequence update:	April 8, 2008
	Last modified:	March 28, 2018
	This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B1AJZ6 (B1AJZ6_HUMAN)

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Protein Wnt

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ