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Protein
Submitted name:

Receptor-type tyrosine-protein phosphatase T

Gene

PTPRT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor-type tyrosine-protein phosphatase TImported
Gene namesi
Name:PTPRTImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9682. PTPRT.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei747 – 768HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500276040926 – 1431Sequence analysisAdd BLAST1406

Proteomic databases

MaxQBiB1AJS0.
PaxDbiB1AJS0.
PeptideAtlasiB1AJS0.
PRIDEiB1AJS0.

Expressioni

Gene expression databases

BgeeiENSG00000196090.
ExpressionAtlasiB1AJS0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362283.

Structurei

3D structure databases

ProteinModelPortaliB1AJS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 191MAMInterPro annotationAdd BLAST162
Domaini193 – 284Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST92
Domaini291 – 384Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini389 – 483Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini484 – 590Fibronectin type-IIIInterPro annotationAdd BLAST107
Domaini879 – 1133Tyrosine-protein phosphataseInterPro annotationAdd BLAST255
Domaini1053 – 1124TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
Domaini1165 – 1427Tyrosine-protein phosphataseInterPro annotationAdd BLAST263
Domaini1341 – 1418TYR_PHOSPHATASE_2InterPro annotationAdd BLAST78

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000049029.
HOVERGENiHBG062785.

Family and domain databases

CDDicd00063. FN3. 3 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AJS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN
60 70 80 90 100
GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT
110 120 130 140 150
HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE
160 170 180 190 200
LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN
210 220 230 240 250
VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA
260 270 280 290 300
TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV
310 320 330 340 350
GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL
360 370 380 390 400
DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA
410 420 430 440 450
RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR
460 470 480 490 500
GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE
510 520 530 540 550
KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH
560 570 580 590 600
HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL
610 620 630 640 650
NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV
660 670 680 690 700
SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS
710 720 730 740 750
YSIYFQALSK ANGETKINCV RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV
760 770 780 790 800
IAGLLMFIII LLGVMLTIKR RKLAKKQKET QSGAQREMGP VASADKPTTK
810 820 830 840 850
LSASRNDEGF SSSSQDVNGF TDGSRGELSQ PTLTIQTHPY RTCDPVEMSY
860 870 880 890 900
PRDQFQPAIR VADLLQHITQ MKRGQGYGFK EEYEALPEGQ TASWDTAKED
910 920 930 940 950
ENRNKNRYGN IISYDHSRVR LLVLDGDPHS DYINANYIDG YHRPRHYIAT
960 970 980 990 1000
QGPMQETVKD FWRMIWQENS ASIVMVTNLV EVGRVKCVRY WPDDTEVYGD
1010 1020 1030 1040 1050
IKVTLIETEP LAEYVIRTFT VQKKGYHEIR ELRLFHFTSW PDHGVPCYAT
1060 1070 1080 1090 1100
GLLGFVRQVK FLNPPEAGPI VVHCSAGAGR TGCFIAIDTM LDMAENEGVV
1110 1120 1130 1140 1150
DIFNCVRELR AQRVNLVQTE EQYVFVHDAI LEACLCGNTA IPVCEFRSLY
1160 1170 1180 1190 1200
YNISRLDPQT NSSQIKDEFQ TLNIVTPRVR PEDCSIGLLP RNHDKNRSMD
1210 1220 1230 1240 1250
VLPLDRCLPF LISVDGESSN YINAALMDSH KQPAAFVVTQ HPLPNTVADF
1260 1270 1280 1290 1300
WRLVFDYNCS SVVMLNEMDT AQFCMQYWPE KTSGCYGPIQ VEFVSADIDE
1310 1320 1330 1340 1350
DIIHRIFRIC NMARPQDGYR IVQHLQYIGW PAYRDTPPSK RSLLKVVRRL
1360 1370 1380 1390 1400
EKWQEQYDGR EGRTVVHCLN GGGRSGTFCA ICSVCEMIQQ QNIIDVFHIV
1410 1420 1430
KTLRNNKSNM VETLEQYKFV YEVALEYLSS F
Length:1,431
Mass (Da):160,853
Last modified:April 8, 2008 - v1
Checksum:iB72B41AE356A7510
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022239 Genomic DNA. No translation available.
AL024473 Genomic DNA. No translation available.
AL035459 Genomic DNA. No translation available.
AL049812 Genomic DNA. No translation available.
AL109826 Genomic DNA. No translation available.
KF456906 Genomic DNA. No translation available.
KF456910 Genomic DNA. No translation available.
Z93942 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000373201; ENSP00000362297; ENSG00000196090.
UCSCiuc061xcc.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022239 Genomic DNA. No translation available.
AL024473 Genomic DNA. No translation available.
AL035459 Genomic DNA. No translation available.
AL049812 Genomic DNA. No translation available.
AL109826 Genomic DNA. No translation available.
KF456906 Genomic DNA. No translation available.
KF456910 Genomic DNA. No translation available.
Z93942 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB1AJS0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362283.

Proteomic databases

MaxQBiB1AJS0.
PaxDbiB1AJS0.
PeptideAtlasiB1AJS0.
PRIDEiB1AJS0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373201; ENSP00000362297; ENSG00000196090.
UCSCiuc061xcc.1. human.

Organism-specific databases

CTDi11122.
HGNCiHGNC:9682. PTPRT.
OpenTargetsiENSG00000196090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000049029.
HOVERGENiHBG062785.

Miscellaneous databases

ChiTaRSiPTPRT. human.
GenomeRNAii11122.

Gene expression databases

BgeeiENSG00000196090.
ExpressionAtlasiB1AJS0. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 3 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB1AJS0_HUMAN
AccessioniPrimary (citable) accession number: B1AJS0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.