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Protein
Submitted name:

Receptor-type tyrosine-protein phosphatase T

Gene

PTPRT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1083Phosphocysteine intermediatePROSITE-ProRule annotation1
Active sitei1377Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Receptor-type tyrosine-protein phosphatase TImported
Gene namesi
Name:PTPRTImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000196090.12.
HGNCiHGNC:9682. PTPRT.

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500276186326 – 1440Sequence analysisAdd BLAST1415

Proteomic databases

MaxQBiB1AJR6.
PaxDbiB1AJR6.
PeptideAtlasiB1AJR6.
PRIDEiB1AJR6.

Expressioni

Gene expression databases

BgeeiENSG00000196090.
ExpressionAtlasiB1AJR6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB1AJR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 191MAMInterPro annotationAdd BLAST162
Domaini193 – 284Ig-likeInterPro annotationAdd BLAST92
Domaini291 – 384Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini389 – 483Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini484 – 590Fibronectin type-IIIInterPro annotationAdd BLAST107
Domaini888 – 1142Tyrosine-protein phosphataseInterPro annotationAdd BLAST255
Domaini1062 – 1133TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
Domaini1174 – 1436Tyrosine-protein phosphataseInterPro annotationAdd BLAST263
Domaini1350 – 1427TYR_PHOSPHATASE_2InterPro annotationAdd BLAST78

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000049029.
HOVERGENiHBG062785.

Family and domain databases

CDDicd00063. FN3. 3 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 5 hits.
3.90.190.10. 2 hits.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00060. FN3. 3 hits.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiView protein in PROSITE
PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.

Sequencei

Sequence statusi: Complete.

B1AJR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN
60 70 80 90 100
GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT
110 120 130 140 150
HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE
160 170 180 190 200
LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN
210 220 230 240 250
VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA
260 270 280 290 300
TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV
310 320 330 340 350
GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL
360 370 380 390 400
DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA
410 420 430 440 450
RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR
460 470 480 490 500
GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE
510 520 530 540 550
KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH
560 570 580 590 600
HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL
610 620 630 640 650
NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV
660 670 680 690 700
SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS
710 720 730 740 750
YSIYFQALSK ANGETKINCV RLATKGASTQ NSNTVEPEKQ VDNTVKMAGV
760 770 780 790 800
IAGLLMFIII LLGVMLTIKR RRNAYSYSYY LKLAKKQKET QSGAQREMGP
810 820 830 840 850
VASADKPTTK LSASRNDEGF SSSSQDVNGF NGSRGELSQP TLTIQTHPYR
860 870 880 890 900
TCDPVEMSYP RDQFQPAIRV ADLLQHITQM KRGQGYGFKE EYEALPEGQT
910 920 930 940 950
ASWDTAKEDE NRNKNRYGNI ISYDHSRVRL LVLDGDPHSD YINANYIDGY
960 970 980 990 1000
HRPRHYIATQ GPMQETVKDF WRMIWQENSA SIVMVTNLVE VGRVKCVRYW
1010 1020 1030 1040 1050
PDDTEVYGDI KVTLIETEPL AEYVIRTFTV QKKGYHEIRE LRLFHFTSWP
1060 1070 1080 1090 1100
DHGVPCYATG LLGFVRQVKF LNPPEAGPIV VHCSAGAGRT GCFIAIDTML
1110 1120 1130 1140 1150
DMAENEGVVD IFNCVRELRA QRVNLVQTEE QYVFVHDAIL EACLCGNTAI
1160 1170 1180 1190 1200
PVCEFRSLYY NISRLDPQTN SSQIKDEFQT LNIVTPRVRP EDCSIGLLPR
1210 1220 1230 1240 1250
NHDKNRSMDV LPLDRCLPFL ISVDGESSNY INAALMDSHK QPAAFVVTQH
1260 1270 1280 1290 1300
PLPNTVADFW RLVFDYNCSS VVMLNEMDTA QFCMQYWPEK TSGCYGPIQV
1310 1320 1330 1340 1350
EFVSADIDED IIHRIFRICN MARPQDGYRI VQHLQYIGWP AYRDTPPSKR
1360 1370 1380 1390 1400
SLLKVVRRLE KWQEQYDGRE GRTVVHCLNG GGRSGTFCAI CSVCEMIQQQ
1410 1420 1430 1440
NIIDVFHIVK TLRNNKSNMV ETLEQYKFVY EVALEYLSSF
Length:1,440
Mass (Da):162,032
Last modified:April 8, 2008 - v1
Checksum:i985426024B9BD2B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022239 Genomic DNA. No translation available.
AL024473 Genomic DNA. No translation available.
AL035459 Genomic DNA. No translation available.
AL049812 Genomic DNA. No translation available.
AL109826 Genomic DNA. No translation available.
KF456906 Genomic DNA. No translation available.
KF456910 Genomic DNA. No translation available.
Z93942 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000373190; ENSP00000362286; ENSG00000196090.
UCSCiuc061xcb.1. human.

Similar proteinsi

Entry informationi

Entry nameiB1AJR6_HUMAN
AccessioniPrimary (citable) accession number: B1AJR6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 25, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported