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B1AJN5 (KITH_UREP2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:UPA3_0634
OrganismUreaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736) [Complete proteome] [HAMAP]
Taxonomic identifier505682 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Thymidine kinase HAMAP-Rule MF_00124
PRO_1000076241

Regions

Nucleotide binding19 – 268ATP By similarity
Nucleotide binding96 – 994ATP By similarity

Sites

Active site971Proton acceptor Potential
Metal binding1531Zinc By similarity
Metal binding1561Zinc By similarity
Metal binding1911Zinc By similarity
Metal binding1941Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
B1AJN5 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 27F3061B26979A0B

FASTA22325,367
        10         20         30         40         50         60 
MAKVNAFSKK IGWIELITGP MFAGKTAELI RRLHRLEYAD VKYLVFKPKI DTRSIRNIQS 

        70         80         90        100        110        120 
RTGTSLPSVE VESAPEILNY IMSNSFNDET KVIGIDEVQF FDDRICEVAN ILAENGFVVI 

       130        140        150        160        170        180 
ISGLDKNFKG EPFGPIAKLF TYADKITKLT AICNECGAEA THSLRKIDGK HADYNDDIVK 

       190        200        210        220 
IGCQEFYSAV CRHHHKVPNR PYLNSNSEEF IKFFKNKKRN KNI 

« Hide

References

[1]"Genome sequence of Ureaplasma parvum serovar 3."
Methe B.A., Glass J., Waites K., Shrivastava S.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27815 / 27 / NCTC 11736.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000942 Genomic DNA. Translation: ACA33062.1.
RefSeqYP_001752679.1. NC_010503.1.

3D structure databases

ProteinModelPortalB1AJN5.
SMRB1AJN5. Positions 11-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING505682.UPA3_0634.

Chemistry

BindingDBB1AJN5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA33062; ACA33062; UPA3_0634.
GeneID6155375.
KEGGupa:UPA3_0634.
PATRIC20533495. VBIUrePar123156_0604.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076390.
KOK00857.
OMAQAICLSC.
OrthoDBEOG69D3J2.

Enzyme and pathway databases

BioCycUPAR505682:GHAZ-638-MONOMER.

Family and domain databases

HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_UREP2
AccessionPrimary (citable) accession number: B1AJN5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families