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B1AJA6 (DEF_UREP2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide deformylase

Short name=PDF
EC=3.5.1.88
Alternative name(s):
Polypeptide deformylase
Gene names
Name:def
Ordered Locus Names:UPA3_0484
OrganismUreaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736) [Complete proteome] [HAMAP]
Taxonomic identifier505682 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP-Rule MF_00163

Catalytic activity

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP-Rule MF_00163

Cofactor

Binds 1 Fe2+ ion By similarity. HAMAP-Rule MF_00163

Sequence similarities

Belongs to the polypeptide deformylase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functioniron ion binding

Inferred from electronic annotation. Source: InterPro

peptide deformylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Peptide deformylase HAMAP-Rule MF_00163
PRO_1000076954

Sites

Active site1681 By similarity
Metal binding1231Iron By similarity
Metal binding1671Iron By similarity
Metal binding1711Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B1AJA6 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 19F035D052625C95

FASTA19823,143
        10         20         30         40         50         60 
MYNIKFLDLL NSNLKPNPQW IFKDPHPILR EVTQDIEGNE LSKDDIYYLK KMVRYIDVCY 

        70         80         90        100        110        120 
HNQAKKYKIR SGIAIAANQV GWNKRATYIH FNDEAKEHHY LLINPHIIKR SSEIAYLNPG 

       130        140        150        160        170        180 
EGCLSVDDDR SGYVIRNKKV HVKAYDLISE QFIDQEFSGI IAICIQHEIG HLDAGLYYDN 

       190 
INQQQPFYAD PSWTKIGR 

« Hide

References

[1]"Genome sequence of Ureaplasma parvum serovar 3."
Methe B.A., Glass J., Waites K., Shrivastava S.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27815 / 27 / NCTC 11736.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000942 Genomic DNA. Translation: ACA32898.1.
RefSeqYP_001752550.1. NC_010503.1.

3D structure databases

ProteinModelPortalB1AJA6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING505682.UPA3_0484.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA32898; ACA32898; UPA3_0484.
GeneID6155644.
KEGGupa:UPA3_0484.
PATRIC20533193. VBIUrePar123156_0473.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0242.
HOGENOMHOG000243507.
KOK01462.
OMAGYVIRSE.
OrthoDBEOG6PZXGQ.

Enzyme and pathway databases

BioCycUPAR505682:GHAZ-487-MONOMER.

Family and domain databases

Gene3D3.90.45.10. 1 hit.
HAMAPMF_00163. Pep_deformylase.
InterProIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERPTHR10458. PTHR10458. 1 hit.
PfamPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFPIRSF004749. Pep_def. 1 hit.
PRINTSPR01576. PDEFORMYLASE.
SUPFAMSSF56420. SSF56420. 1 hit.
TIGRFAMsTIGR00079. pept_deformyl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDEF_UREP2
AccessionPrimary (citable) accession number: B1AJA6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families