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B1AJ10

- SYL_UREP2

UniProt

B1AJ10 - SYL_UREP2

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciUPAR505682:GHAZ-390-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:UPA3_0387
OrganismiUreaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)
Taxonomic identifieri505682 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
ProteomesiUP000002162: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Leucine--tRNA ligasePRO_1000074849Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi505682.UPA3_0387.

Structurei

3D structure databases

ProteinModelPortaliB1AJ10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi580 – 5845"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AJ10-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYNHNKIEKK WQKYWLDNKT FKFVDNPNNP KKFYVLDMFP YPSGKGLHVG
60 70 80 90 100
HPKGYTATDV ISRFKRLNGY DVLHPIGWDA FGLPAEQYAL ETNNHPHTFT
110 120 130 140 150
QQNIKIFRKQ LQMIGFDFDY DKEVDTTDPQ FYQWTQWIFV QLYKHNLAEI
160 170 180 190 200
QDIDVNWCEN LGTVLSNEEV VLNDKNERVS ERGGHPVVRK PMKQWVLKIV
210 220 230 240 250
DYADKLLDGL NEVEFSESLK SLQRNWIGKS IGTSVQFKIK DSLLTLDVFT
260 270 280 290 300
TRIDTIYGVQ YLVVAPEHPI LKSITSEQQI NVVQSYIEQT KKISDLDRIA
310 320 330 340 350
DTNKTGVFSG AYAINPINQE IIPIWVSDYV LMNFATGAVM GVPAHDERDY
360 370 380 390 400
AFAKKYALPI KSVIDTKQKL PYAGDGLHIN SAMINGLNIK QSQNVLNDYL
410 420 430 440 450
IKNHLGKKVA NYKLRNWIFS RQRYWGEPFP VLFDENNQIK IIEDLPVLLP
460 470 480 490 500
NLNEFKPSKT GESPLANAQE WLYVEIDGKK YRRETNTMPQ WAGSSWYFLA
510 520 530 540 550
YILKNEDGSY TPLNSEEAKK RFAKWLPVDV YIGGQEHAVL HLLYSRFWHR
560 570 580 590 600
FLYDIGVVPT KEPFYKVINQ GMILGENNEK MSKSKGNVIN PDDIIASHGA
610 620 630 640 650
DTLRIYEMFM GPLTASLPWN PDGLDAMRKW LDRVYRLYHN LSELEVVEDL
660 670 680 690 700
NKLNEEIIIA YHTLIKNYTK AINEQAFNIA ISEMMVFVNV LYKNKVINYE
710 720 730 740 750
LLDNFLILLS CYAPHLAEEL YSLNHSESVC LQKMPIYDEQ KIIAQNITIP
760 770 780 790 800
IQINGKLKHT INVLRDTNAE ELVNLALACE QVKQEIGDQP IKKQIVVVNK

IINFVI
Length:806
Mass (Da):93,299
Last modified:April 8, 2008 - v1
Checksum:iB5F61AFE314A41A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000942 Genomic DNA. Translation: ACA33294.1.
RefSeqiWP_010891746.1. NC_010503.1.
YP_001752454.1. NC_010503.1.

Genome annotation databases

EnsemblBacteriaiACA33294; ACA33294; UPA3_0387.
GeneIDi6155445.
KEGGiupa:UPA3_0387.
PATRICi20532998. VBIUrePar123156_0377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000942 Genomic DNA. Translation: ACA33294.1 .
RefSeqi WP_010891746.1. NC_010503.1.
YP_001752454.1. NC_010503.1.

3D structure databases

ProteinModelPortali B1AJ10.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 505682.UPA3_0387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA33294 ; ACA33294 ; UPA3_0387 .
GeneIDi 6155445.
KEGGi upa:UPA3_0387.
PATRICi 20532998. VBIUrePar123156_0377.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci UPAR505682:GHAZ-390-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Ureaplasma parvum serovar 3."
    Methe B.A., Glass J., Waites K., Shrivastava S.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27815 / 27 / NCTC 11736.

Entry informationi

Entry nameiSYL_UREP2
AccessioniPrimary (citable) accession number: B1AJ10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3