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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei583ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:UPA3_0387
OrganismiUreaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)
Taxonomic identifieri505682 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma

Subcellular locationi

B1AJ10:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000748491 – 806Leucine--tRNA ligaseAdd BLAST806

Structurei

3D structure databases

ProteinModelPortaliB1AJ10.
SMRiB1AJ10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi580 – 584"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200748.
KOiK01869.
OMAiTFMVLAP.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 2 hits.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

B1AJ10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNHNKIEKK WQKYWLDNKT FKFVDNPNNP KKFYVLDMFP YPSGKGLHVG
60 70 80 90 100
HPKGYTATDV ISRFKRLNGY DVLHPIGWDA FGLPAEQYAL ETNNHPHTFT
110 120 130 140 150
QQNIKIFRKQ LQMIGFDFDY DKEVDTTDPQ FYQWTQWIFV QLYKHNLAEI
160 170 180 190 200
QDIDVNWCEN LGTVLSNEEV VLNDKNERVS ERGGHPVVRK PMKQWVLKIV
210 220 230 240 250
DYADKLLDGL NEVEFSESLK SLQRNWIGKS IGTSVQFKIK DSLLTLDVFT
260 270 280 290 300
TRIDTIYGVQ YLVVAPEHPI LKSITSEQQI NVVQSYIEQT KKISDLDRIA
310 320 330 340 350
DTNKTGVFSG AYAINPINQE IIPIWVSDYV LMNFATGAVM GVPAHDERDY
360 370 380 390 400
AFAKKYALPI KSVIDTKQKL PYAGDGLHIN SAMINGLNIK QSQNVLNDYL
410 420 430 440 450
IKNHLGKKVA NYKLRNWIFS RQRYWGEPFP VLFDENNQIK IIEDLPVLLP
460 470 480 490 500
NLNEFKPSKT GESPLANAQE WLYVEIDGKK YRRETNTMPQ WAGSSWYFLA
510 520 530 540 550
YILKNEDGSY TPLNSEEAKK RFAKWLPVDV YIGGQEHAVL HLLYSRFWHR
560 570 580 590 600
FLYDIGVVPT KEPFYKVINQ GMILGENNEK MSKSKGNVIN PDDIIASHGA
610 620 630 640 650
DTLRIYEMFM GPLTASLPWN PDGLDAMRKW LDRVYRLYHN LSELEVVEDL
660 670 680 690 700
NKLNEEIIIA YHTLIKNYTK AINEQAFNIA ISEMMVFVNV LYKNKVINYE
710 720 730 740 750
LLDNFLILLS CYAPHLAEEL YSLNHSESVC LQKMPIYDEQ KIIAQNITIP
760 770 780 790 800
IQINGKLKHT INVLRDTNAE ELVNLALACE QVKQEIGDQP IKKQIVVVNK

IINFVI
Length:806
Mass (Da):93,299
Last modified:April 8, 2008 - v1
Checksum:iB5F61AFE314A41A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000942 Genomic DNA. Translation: ACA33294.1.
RefSeqiWP_010891746.1. NC_010503.1.

Genome annotation databases

EnsemblBacteriaiACA33294; ACA33294; UPA3_0387.
GeneIDi29672253.
KEGGiupa:UPA3_0387.

Similar proteinsi

Entry informationi

Entry nameiSYL_UREP2
AccessioniPrimary (citable) accession number: B1AJ10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: October 25, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families