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B1AIQ8

- TRMB_UREP2

UniProt

B1AIQ8 - TRMB_UREP2

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451S-adenosyl-L-methionineUniRule annotation
Binding sitei70 – 701S-adenosyl-L-methionineUniRule annotation
Binding sitei97 – 971S-adenosyl-L-methionineUniRule annotation
Active sitei119 – 1191By similarity
Binding sitei119 – 1191S-adenosyl-L-methionineUniRule annotation
Binding sitei123 – 1231SubstrateUniRule annotation
Binding sitei155 – 1551SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciUPAR505682:GHAZ-279-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:UPA3_0277
OrganismiUreaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)
Taxonomic identifieri505682 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
ProteomesiUP000002162: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferasePRO_1000084454Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi505682.UPA3_0277.

Structurei

3D structure databases

ProteinModelPortaliB1AIQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2024Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiGCGKGEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AIQ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLRNNANAP LYLKSQHEYI INDPHLLKDN LGKIFKNPEL PLYIEIGMGK
60 70 80 90 100
GDFIIENALR NQQINYLGIE KFPTVIVKAH KKALKHKLDN LAMICFDANK
110 120 130 140 150
ILELLNSESV DKIYLNFSDP WPKKRHAKKR LTHPCFLEKF AVILKQNALV
160 170 180 190 200
EFKTDNENLF MYTIYDVLLK DLTKYEILFL TYNLYTLVNN VELLKNIPTE
210 220
YEKKFVMQGE RIKKVNFRFL KNNQ
Length:224
Mass (Da):26,494
Last modified:April 8, 2008 - v1
Checksum:iFB6152538C75CBBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000942 Genomic DNA. Translation: ACA33200.1.
RefSeqiYP_001752352.1. NC_010503.1.

Genome annotation databases

EnsemblBacteriaiACA33200; ACA33200; UPA3_0277.
GeneIDi6155488.
KEGGiupa:UPA3_0277.
PATRICi20532776. VBIUrePar123156_0275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000942 Genomic DNA. Translation: ACA33200.1 .
RefSeqi YP_001752352.1. NC_010503.1.

3D structure databases

ProteinModelPortali B1AIQ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 505682.UPA3_0277.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA33200 ; ACA33200 ; UPA3_0277 .
GeneIDi 6155488.
KEGGi upa:UPA3_0277.
PATRICi 20532776. VBIUrePar123156_0275.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi GCGKGEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci UPAR505682:GHAZ-279-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Ureaplasma parvum serovar 3."
    Methe B.A., Glass J., Waites K., Shrivastava S.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27815 / 27 / NCTC 11736.

Entry informationi

Entry nameiTRMB_UREP2
AccessioniPrimary (citable) accession number: B1AIQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3