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Protein

Fibulin-1

Gene

FBLN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibulin-1UniRule annotation
Gene namesi
Name:FBLN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:3600. FBLN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrixUniRule annotation, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 721692Fibulin-1Sequence analysisPRO_5002759898Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiB1AHL2.
PRIDEiB1AHL2.

Expressioni

Gene expression databases

BgeeiENSG00000077942.
ExpressionAtlasiB1AHL2. baseline and differential.

Interactioni

Subunit structurei

Homomultimerizes and interacts with various extracellular matrix components.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB1AHL2.
SMRiB1AHL2. Positions 222-605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 14834Anaphylatoxin-likeInterPro annotationAdd
BLAST
Domaini150 – 18233Anaphylatoxin-likeInterPro annotationAdd
BLAST
Domaini346 – 38035EGF-likeInterPro annotationAdd
BLAST
Domaini394 – 43643EGF-likeInterPro annotationAdd
BLAST
Domaini437 – 47842EGF-likeInterPro annotationAdd
BLAST
Domaini479 – 51840EGF-likeInterPro annotationAdd
BLAST
Domaini519 – 56244EGF-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the fibulin family.UniRule annotation

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000118806.
HOGENOMiHOG000007079.
OrthoDBiEOG091G02LJ.
PhylomeDBiB1AHL2.

Family and domain databases

InterProiIPR000020. Anaphylatoxin/fibulin.
IPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017048. Fibulin-1.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF12662. cEGF. 3 hits.
PF07645. EGF_CA. 4 hits.
[Graphical view]
PIRSFiPIRSF036313. Fibulin-1. 1 hit.
SMARTiSM00104. ANATO. 3 hits.
SM00181. EGF. 9 hits.
SM00179. EGF_CA. 8 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS01177. ANAPHYLATOXIN_1. 2 hits.
PS01178. ANAPHYLATOXIN_2. 2 hits.
PS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AHL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERAAPSRRV PLPLLLLGGL ALLAAGVDAD VLLEACCADG HRMATHQKDC
60 70 80 90 100
SLPYATESKE CRAVGLASLC QDLNGAWAVW KVGRASQAEG TASARAQRRG
110 120 130 140 150
MVQEQCCHSQ LEELHCATGI SLANEQDRCA TPHGDNASLE ATFVKRCCHC
160 170 180 190 200
CLLGRAAQAQ GQSCEYSLMV GYQCGQVFQA CCVKSQETGD LDVGGLQETD
210 220 230 240 250
KIIEVEEEQE DPYLNDRCRG GGPCKQQCRD TGDEVVCSCF VGYQLLSDGV
260 270 280 290 300
SCEDVNECIT GSHSCRLGES CINTVGSFRC QRDSSCGTGY ELTEDNSCKD
310 320 330 340 350
IDECESGIHN CLPDFICQNT LGSFRCRPKL QCKSGFIQDA LGNCIDINEC
360 370 380 390 400
LSISAPCPIG HTCINTEGSY TCQKNVPNCG RGYHLNEEGT RCVDVDECAP
410 420 430 440 450
PAEPCGKGHR CVNSPGSFRC ECKTGYYFDG ISRMCVDVNE CQRYPGRLCG
460 470 480 490 500
HKCENTLGSY LCSCSVGFRL SVDGRSCEDI NECSSSPCSQ ECANVYGSYQ
510 520 530 540 550
CYCRRGYQLS DVDGVTCEDI DECALPTGGH ICSYRCINIP GSFQCSCPSS
560 570 580 590 600
GYRLAPNGRN CQDIDECVTG IHNCSINETC FNIQGGFRCL AFECPENYRR
610 620 630 640 650
SAATRCERLP CHENRECSKL PLRITYYHLS FPTNIQAPAV VFRMGPSSAV
660 670 680 690 700
PGDSMQLAIT GGNEEGFFTT RKVSPHSGVV ALTKPVPEPR DLLLTVKMDL
710 720
SRHGTVSSFV AKLFIFVSAE L
Length:721
Mass (Da):78,329
Last modified:March 2, 2010 - v1
Checksum:iB65CBC82102501D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021391 Genomic DNA. No translation available.
KF457485 Genomic DNA. No translation available.
Z95331 Genomic DNA. No translation available.
Z98047 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000402984; ENSP00000385521; ENSG00000077942.
UCSCiuc010gzz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021391 Genomic DNA. No translation available.
KF457485 Genomic DNA. No translation available.
Z95331 Genomic DNA. No translation available.
Z98047 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB1AHL2.
SMRiB1AHL2. Positions 222-605.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB1AHL2.
PRIDEiB1AHL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000402984; ENSP00000385521; ENSG00000077942.
UCSCiuc010gzz.4. human.

Organism-specific databases

HGNCiHGNC:3600. FBLN1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118806.
HOGENOMiHOG000007079.
OrthoDBiEOG091G02LJ.
PhylomeDBiB1AHL2.

Miscellaneous databases

ChiTaRSiFBLN1. human.

Gene expression databases

BgeeiENSG00000077942.
ExpressionAtlasiB1AHL2. baseline and differential.

Family and domain databases

InterProiIPR000020. Anaphylatoxin/fibulin.
IPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017048. Fibulin-1.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF12662. cEGF. 3 hits.
PF07645. EGF_CA. 4 hits.
[Graphical view]
PIRSFiPIRSF036313. Fibulin-1. 1 hit.
SMARTiSM00104. ANATO. 3 hits.
SM00181. EGF. 9 hits.
SM00179. EGF_CA. 8 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
PROSITEiPS01177. ANAPHYLATOXIN_1. 2 hits.
PS01178. ANAPHYLATOXIN_2. 2 hits.
PS00010. ASX_HYDROXYL. 4 hits.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB1AHL2_HUMAN
AccessioniPrimary (citable) accession number: B1AHL2
Secondary accession number(s): C9JMQ3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.