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Protein

DNA helicase

Gene

MCM5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HelicaseSAAS annotation, Hydrolase
Biological processCell cycle, Cell divisionImported, DNA replicationSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Name:MCM5Imported
ORF Names:hCG_41525Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:6948. MCM5.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100297.

PTM / Processingi

Proteomic databases

MaxQBiB1AHB1.

Expressioni

Gene expression databases

BgeeiENSG00000100297.
ExpressionAtlasiB1AHB1. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 493MCMInterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the MCM family.UniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074928.
HOGENOMiHOG000224128.
HOVERGENiHBG104907.

Family and domain databases

InterProiView protein in InterPro
IPR031327. MCM.
IPR008048. MCM5.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR033762. MCM_OB.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11630:SF87. PTHR11630:SF87. 1 hit.
PfamiView protein in Pfam
PF00493. MCM. 1 hit.
PF14551. MCM_N. 1 hit.
PF17207. MCM_OB. 1 hit.
PRINTSiPR01657. MCMFAMILY.
PR01661. MCMPROTEIN5.
SMARTiView protein in SMART
SM00350. MCM. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B1AHB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFDDPGIF YSDSFGGDAQ ADEGQARKSQ LQRRFKEFLR QYRVGTDRTG
60 70 80 90 100
FTFKYRDELK RHYNLGEYWI EVEMEDLASF DEDLADYLYK QPAEHLQLSD
110 120 130 140 150
MMSHLVKIPG IIIAASAVRA KATRISIQCR SCRNTLTNIA MRPGLEGYAL
160 170 180 190 200
PRKCNTDQAG RPKCPLDPYF IMPDKCKCVD FQTLKLQELP DAVPHGEMPR
210 220 230 240 250
HMQLYCDRYL CDKVVPGNRV TIMGIYSIKK FGLTTSRGRD RVGVGIRSSY
260 270 280 290 300
IRVLGIQVDT DGSGRSFAGA VSPQEEEEFR RLAALPNVYE VISKSIAPSI
310 320 330 340 350
FGGTDMKKAI ACLLFGGSRK RLPDGLTRRG DINLLMLGDP GTAKSQLLKF
360 370 380 390 400
VEKCSPIGVY TSGKGSSAAG LTASVMRDPS SRNFIMEGGA MVLADGGVVC
410 420 430 440 450
IDEFDKMRED DRVAIHEAME QQTISIAKAG ITTTLNSRCS VLAAANSVFG
460 470 480 490 500
RWDETKGEDN IDFMPTILSR FDMIFIVKDE HNEERDVMLA KHVITLHVSA
510 520 530 540 550
LTQTQAVEGE IDLAKLKKFI AYCRVKCGPR LSAEAAEKLK NRYIIMRSGA
560 570 580 590 600
RQHERDSDRR SSIPITVRQL EAIVRIAEAL SKMKLQPFAT EADVEEALRL
610 620 630 640 650
FQVSTLDAAL SGTLSGVEGF TSQEDQEMLS RIEKQLKRRF AIGSQVSEHS
660 670 680 690
IIKDFTKQKY PEHAIHKVLQ LMLRRGEIQH RMQRKVLYRL K
Length:691
Mass (Da):77,593
Last modified:April 8, 2008 - v1
Checksum:i95EA787929FC254A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82244 Genomic DNA. No translation available.
CH471095 Genomic DNA. Translation: EAW60062.1.
UniGeneiHs.517582.

Genome annotation databases

EnsembliENST00000382011; ENSP00000371441; ENSG00000100297.
UCSCiuc003anv.5. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB1AHB1_HUMAN
AccessioniPrimary (citable) accession number: B1AHB1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 5, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported