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Protein

DNA helicase

Gene

MCM5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HelicaseSAAS annotation, Hydrolase
Biological processCell cycle, Cell divisionImported, DNA replicationSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Name:MCM5Imported
ORF Names:hCG_41525Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100297.15
HGNCiHGNC:6948 MCM5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100297

PTM / Processingi

Proteomic databases

MaxQBiB1AHB1
PeptideAtlasiB1AHB1

Expressioni

Gene expression databases

BgeeiENSG00000100297

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini288 – 493MCMInterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the MCM family.UniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074928
HOGENOMiHOG000224128
HOVERGENiHBG104907

Family and domain databases

InterProiView protein in InterPro
IPR031327 MCM
IPR008048 MCM5
IPR018525 MCM_CS
IPR001208 MCM_dom
IPR027925 MCM_N
IPR033762 MCM_OB
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
PANTHERiPTHR11630 PTHR11630, 2 hits
PfamiView protein in Pfam
PF00493 MCM, 1 hit
PF14551 MCM_N, 1 hit
PF17207 MCM_OB, 1 hit
PRINTSiPR01657 MCMFAMILY
PR01661 MCMPROTEIN5
SMARTiView protein in SMART
SM00350 MCM, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00847 MCM_1, 1 hit
PS50051 MCM_2, 1 hit

Sequencei

Sequence statusi: Complete.

B1AHB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFDDPGIF YSDSFGGDAQ ADEGQARKSQ LQRRFKEFLR QYRVGTDRTG
60 70 80 90 100
FTFKYRDELK RHYNLGEYWI EVEMEDLASF DEDLADYLYK QPAEHLQLSD
110 120 130 140 150
MMSHLVKIPG IIIAASAVRA KATRISIQCR SCRNTLTNIA MRPGLEGYAL
160 170 180 190 200
PRKCNTDQAG RPKCPLDPYF IMPDKCKCVD FQTLKLQELP DAVPHGEMPR
210 220 230 240 250
HMQLYCDRYL CDKVVPGNRV TIMGIYSIKK FGLTTSRGRD RVGVGIRSSY
260 270 280 290 300
IRVLGIQVDT DGSGRSFAGA VSPQEEEEFR RLAALPNVYE VISKSIAPSI
310 320 330 340 350
FGGTDMKKAI ACLLFGGSRK RLPDGLTRRG DINLLMLGDP GTAKSQLLKF
360 370 380 390 400
VEKCSPIGVY TSGKGSSAAG LTASVMRDPS SRNFIMEGGA MVLADGGVVC
410 420 430 440 450
IDEFDKMRED DRVAIHEAME QQTISIAKAG ITTTLNSRCS VLAAANSVFG
460 470 480 490 500
RWDETKGEDN IDFMPTILSR FDMIFIVKDE HNEERDVMLA KHVITLHVSA
510 520 530 540 550
LTQTQAVEGE IDLAKLKKFI AYCRVKCGPR LSAEAAEKLK NRYIIMRSGA
560 570 580 590 600
RQHERDSDRR SSIPITVRQL EAIVRIAEAL SKMKLQPFAT EADVEEALRL
610 620 630 640 650
FQVSTLDAAL SGTLSGVEGF TSQEDQEMLS RIEKQLKRRF AIGSQVSEHS
660 670 680 690
IIKDFTKQKY PEHAIHKVLQ LMLRRGEIQH RMQRKVLYRL K
Length:691
Mass (Da):77,593
Last modified:April 8, 2008 - v1
Checksum:i95EA787929FC254A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82244 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60062.1
UniGeneiHs.517582

Genome annotation databases

EnsembliENST00000382011; ENSP00000371441; ENSG00000100297
UCSCiuc003anv.5 human

Similar proteinsi

Entry informationi

Entry nameiB1AHB1_HUMAN
AccessioniPrimary (citable) accession number: B1AHB1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health