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B1AH88

- TSPOB_HUMAN

UniProt

B1AH88 - TSPOB_HUMAN

Protein

Putative peripheral benzodiazepine receptor-related protein

Gene

TSPO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative peripheral benzodiazepine receptor-related protein
    Gene namesi
    Name:TSPO
    Synonyms:PBRS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:1158. TSPO.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25473.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 102102Putative peripheral benzodiazepine receptor-related proteinPRO_0000379595Add
    BLAST

    Proteomic databases

    PRIDEiB1AH88.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiB1AH88.
    BgeeiB1AH88.
    GenevestigatoriB1AH88.

    Organism-specific databases

    HPAiCAB011232.

    Interactioni

    Protein-protein interaction databases

    BioGridi107168. 3 interactions.
    STRINGi9606.ENSP00000328973.

    Structurei

    3D structure databases

    ProteinModelPortaliB1AH88.
    ModBaseiSearch...
    MobiDBiSearch...

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: B1AH88-1) [UniParc]FASTAAdd to Basket

    Also known as: PBR-S

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPHLLWCPT NGLGLGGSPA GQWGGGSHYR GLVPGEPAGR PPALPLPGLA    50
    GLHDHTQLLR MAGQPWLAWG TAAARVSARP TRDCSCTSRC HHACDVVAVT 100
    LS 102

    Note: No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support.

    Length:102
    Mass (Da):10,537
    Last modified:April 8, 2008 - v1
    Checksum:iE439ABAB50F56CA8
    GO
    Isoform 1 (identifier: P30536-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P30536.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:169
    Mass (Da):18,828
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261G → S in CAG33288. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531H → R.3 Publications
    Corresponds to variant rs6971 [ dbSNP | Ensembl ].
    VAR_059840

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21950 mRNA. Translation: AAA18227.1.
    CR457007 mRNA. Translation: CAG33288.1.
    Z82214 Genomic DNA. Translation: CAQ09717.1.
    CH471138 Genomic DNA. Translation: EAW73290.1.
    PIRiA49361.
    UniGeneiHs.202.

    Genome annotation databases

    EnsembliENST00000396265; ENSP00000379563; ENSG00000100300. [B1AH88-1]
    UCSCiuc003bdo.4. human. [B1AH88-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21950 mRNA. Translation: AAA18227.1 .
    CR457007 mRNA. Translation: CAG33288.1 .
    Z82214 Genomic DNA. Translation: CAQ09717.1 .
    CH471138 Genomic DNA. Translation: EAW73290.1 .
    PIRi A49361.
    UniGenei Hs.202.

    3D structure databases

    ProteinModelPortali B1AH88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107168. 3 interactions.
    STRINGi 9606.ENSP00000328973.

    Chemistry

    BindingDBi B1AH88.

    Proteomic databases

    PRIDEi B1AH88.

    Protocols and materials databases

    DNASUi 706.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396265 ; ENSP00000379563 ; ENSG00000100300 . [B1AH88-1 ]
    UCSCi uc003bdo.4. human. [B1AH88-1 ]

    Organism-specific databases

    GeneCardsi GC22P043547.
    HGNCi HGNC:1158. TSPO.
    HPAi CAB011232.
    neXtProti NX_B1AH88.
    PharmGKBi PA25473.
    GenAtlasi Search...

    Miscellaneous databases

    ChiTaRSi TSPO. human.
    NextBioi 27031789.

    Gene expression databases

    ArrayExpressi B1AH88.
    Bgeei B1AH88.
    Genevestigatori B1AH88.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia."
      Lin D., Chang Y.J., Strauss J.F., Miller W.L.
      Genomics 18:643-650(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ARG-53.
      Tissue: Placenta.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-53.
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-53.

    Entry informationi

    Entry nameiTSPOB_HUMAN
    AccessioniPrimary (citable) accession number: B1AH88
    Secondary accession number(s): Q13849, Q6IAZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3