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B1AH88

- TSPOB_HUMAN

UniProt

B1AH88 - TSPOB_HUMAN

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Protein
Putative peripheral benzodiazepine receptor-related protein
Gene
TSPO, PBRS
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative peripheral benzodiazepine receptor-related protein
Gene namesi
Name:TSPO
Synonyms:PBRS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:1158. TSPO.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25473.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 102102Putative peripheral benzodiazepine receptor-related protein
PRO_0000379595Add
BLAST

Proteomic databases

PRIDEiB1AH88.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiB1AH88.
BgeeiB1AH88.
GenevestigatoriB1AH88.

Organism-specific databases

HPAiCAB011232.

Interactioni

Protein-protein interaction databases

BioGridi107168. 3 interactions.
STRINGi9606.ENSP00000328973.

Structurei

3D structure databases

ProteinModelPortaliB1AH88.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: B1AH88-1) [UniParc]FASTAAdd to Basket

Also known as: PBR-S

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPHLLWCPT NGLGLGGSPA GQWGGGSHYR GLVPGEPAGR PPALPLPGLA    50
GLHDHTQLLR MAGQPWLAWG TAAARVSARP TRDCSCTSRC HHACDVVAVT 100
LS 102

Note: No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support.

Length:102
Mass (Da):10,537
Last modified:April 8, 2008 - v1
Checksum:iE439ABAB50F56CA8
GO
Isoform 1 (identifier: P30536-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P30536.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:169
Mass (Da):18,828
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531H → R.3 Publications
Corresponds to variant rs6971 [ dbSNP | Ensembl ].
VAR_059840

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261G → S in CAG33288. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L21950 mRNA. Translation: AAA18227.1.
CR457007 mRNA. Translation: CAG33288.1.
Z82214 Genomic DNA. Translation: CAQ09717.1.
CH471138 Genomic DNA. Translation: EAW73290.1.
PIRiA49361.
UniGeneiHs.202.

Genome annotation databases

EnsembliENST00000396265; ENSP00000379563; ENSG00000100300. [B1AH88-1]
UCSCiuc003bdo.4. human. [B1AH88-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L21950 mRNA. Translation: AAA18227.1 .
CR457007 mRNA. Translation: CAG33288.1 .
Z82214 Genomic DNA. Translation: CAQ09717.1 .
CH471138 Genomic DNA. Translation: EAW73290.1 .
PIRi A49361.
UniGenei Hs.202.

3D structure databases

ProteinModelPortali B1AH88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107168. 3 interactions.
STRINGi 9606.ENSP00000328973.

Chemistry

BindingDBi B1AH88.

Proteomic databases

PRIDEi B1AH88.

Protocols and materials databases

DNASUi 706.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396265 ; ENSP00000379563 ; ENSG00000100300 . [B1AH88-1 ]
UCSCi uc003bdo.4. human. [B1AH88-1 ]

Organism-specific databases

GeneCardsi GC22P043547.
HGNCi HGNC:1158. TSPO.
HPAi CAB011232.
neXtProti NX_B1AH88.
PharmGKBi PA25473.
GenAtlasi Search...

Miscellaneous databases

ChiTaRSi TSPO. human.
NextBioi 27031789.

Gene expression databases

ArrayExpressi B1AH88.
Bgeei B1AH88.
Genevestigatori B1AH88.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia."
    Lin D., Chang Y.J., Strauss J.F., Miller W.L.
    Genomics 18:643-650(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ARG-53.
    Tissue: Placenta.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-53.
  3. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-53.

Entry informationi

Entry nameiTSPOB_HUMAN
AccessioniPrimary (citable) accession number: B1AH88
Secondary accession number(s): Q13849, Q6IAZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 8, 2008
Last modified: March 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3