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B1AH87

- B1AH87_HUMAN

UniProt

B1AH87 - B1AH87_HUMAN

Protein
Submitted name:

Putative peripheral benzodiazepine receptor-related protein

Gene

TSPO

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. androgen binding Source: Ensembl
    2. benzodiazepine receptor activity Source: Ensembl

    GO - Biological processi

    1. adrenal gland development Source: Ensembl
    2. aging Source: Ensembl
    3. behavioral response to pain Source: Ensembl
    4. cellular hypotonic response Source: Ensembl
    5. cellular response to lipopolysaccharide Source: Ensembl
    6. cellular response to zinc ion Source: Ensembl
    7. chloride transport Source: Ensembl
    8. contact inhibition Source: Ensembl
    9. glial cell migration Source: Ensembl
    10. negative regulation of glial cell proliferation Source: Ensembl
    11. negative regulation of nitric oxide biosynthetic process Source: Ensembl
    12. negative regulation of tumor necrosis factor production Source: Ensembl
    13. peripheral nervous system axon regeneration Source: Ensembl
    14. positive regulation of apoptotic process Source: Ensembl
    15. positive regulation of calcium ion transport Source: Ensembl
    16. positive regulation of glial cell proliferation Source: Ensembl
    17. positive regulation of mitochondrial depolarization Source: Ensembl
    18. positive regulation of necrotic cell death Source: Ensembl
    19. positive regulation of reactive oxygen species metabolic process Source: Ensembl
    20. regulation of steroid biosynthetic process Source: Ensembl
    21. response to drug Source: Ensembl
    22. response to manganese ion Source: Ensembl
    23. response to progesterone Source: Ensembl
    24. response to testosterone Source: Ensembl
    25. response to vitamin B1 Source: Ensembl
    26. steroid biosynthetic process Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative peripheral benzodiazepine receptor-related proteinImported
    Gene namesi
    Name:TSPOImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:1158. TSPO.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. integral component of membrane Source: InterPro
    3. intracellular membrane-bounded organelle Source: HPA
    4. mitochondrial outer membrane Source: Ensembl
    5. mitochondrion Source: HPA
    6. nuclear membrane Source: HPA

    PTM / Processingi

    Proteomic databases

    PRIDEiB1AH87.

    Expressioni

    Gene expression databases

    ArrayExpressiB1AH87.

    Structurei

    3D structure databases

    ProteinModelPortaliB1AH87.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000224659.
    HOVERGENiHBG001296.

    Family and domain databases

    InterProiIPR004307. TspO_MBR.
    [Graphical view]
    PANTHERiPTHR10057. PTHR10057. 1 hit.
    PfamiPF03073. TspO_MBR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    B1AH87-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG    50
    PVWGTLYSAM GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF 100
    GARQMGW 107
    Length:107
    Mass (Da):11,896
    Last modified:April 8, 2008 - v1
    Checksum:i26DF39D8A64DEEB1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei107 – 1071Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z82214 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000428336; ENSP00000405685; ENSG00000100300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z82214 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali B1AH87.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B1AH87.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000428336 ; ENSP00000405685 ; ENSG00000100300 .

    Organism-specific databases

    HGNCi HGNC:1158. TSPO.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000224659.
    HOVERGENi HBG001296.

    Miscellaneous databases

    ChiTaRSi TSPO. human.
    NextBioi 35466364.

    Gene expression databases

    ArrayExpressi B1AH87.

    Family and domain databases

    InterProi IPR004307. TspO_MBR.
    [Graphical view ]
    PANTHERi PTHR10057. PTHR10057. 1 hit.
    Pfami PF03073. TspO_MBR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiB1AH87_HUMAN
    AccessioniPrimary (citable) accession number: B1AH87
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3