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Protein
Submitted name:

Growth hormone 1 isoform 4

Gene

GH1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

HormoneUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Growth hormone 1 isoform 4Imported
Submitted name:
HCG1749481, isoform CRA_gImported
Submitted name:
SomatotropinImported
Gene namesi
Name:GH1Imported
ORF Names:hCG_1749481Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:4261. GH1.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000259384.
PharmGKBiPA171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500763816527 – 122Sequence analysisAdd BLAST96

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiB1A4G9.

Expressioni

Gene expression databases

BgeeiENSG00000259384.
ExpressionAtlasiB1A4G9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312673.

Structurei

3D structure databases

ProteinModelPortaliB1A4G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.

Family and domain databases

Gene3Di1.20.1250.10. 2 hits.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1A4G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATGSRTSLL LAFGLLCLPW LQEGSAFPTI PLSRLFDNAM LRAHRLHQLA
60 70 80 90 100
FDTYQEFRLE DGSPRTGQIF KQTYSKFDTN SHNDDALLKN YGLLYCFRKD
110 120
MDKVETFLRI VQCRSVEGSC GF
Length:122
Mass (Da):13,993
Last modified:October 14, 2008 - v1
Checksum:i8B2818832ED925C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127029 Genomic DNA. No translation available.
EU421712 Genomic DNA. Translation: ABZ88714.1.
CH471109 Genomic DNA. Translation: EAW94239.1.
UniGeneiHs.655229.

Genome annotation databases

EnsembliENST00000342364; ENSP00000339278; ENSG00000259384.
UCSCiuc002jdl.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127029 Genomic DNA. No translation available.
EU421712 Genomic DNA. Translation: ABZ88714.1.
CH471109 Genomic DNA. Translation: EAW94239.1.
UniGeneiHs.655229.

3D structure databases

ProteinModelPortaliB1A4G9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312673.

Proteomic databases

PeptideAtlasiB1A4G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342364; ENSP00000339278; ENSG00000259384.
UCSCiuc002jdl.3. human.

Organism-specific databases

HGNCiHGNC:4261. GH1.
OpenTargetsiENSG00000259384.
PharmGKBiPA171.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.

Miscellaneous databases

ChiTaRSiGH1. human.

Gene expression databases

BgeeiENSG00000259384.
ExpressionAtlasiB1A4G9. baseline and differential.

Family and domain databases

Gene3Di1.20.1250.10. 2 hits.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB1A4G9_HUMAN
AccessioniPrimary (citable) accession number: B1A4G9
Secondary accession number(s): A6NP12
Entry historyi
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.