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Protein

Venom dipeptidyl peptidase 4

Gene
N/A
Organism
Vespula vulgaris (Yellow jacket) (Wasp)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. May process venom proteins into their active forms and/or modulate the chemotactic activity of immune cells after the insect sting.1 Publication

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.1 Publication

Enzyme regulationi

Inhibited by diprotin A.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei638Charge relay systemBy similarity1
Active sitei717Charge relay systemBy similarity1
Active sitei749Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERivesvu-vddp4. DPP4N_Peptidase_S9.

Names & Taxonomyi

Protein namesi
Recommended name:
Venom dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Venom dipeptidyl peptidase IV
Allergen: Ves v 3
OrganismiVespula vulgaris (Yellow jacket) (Wasp)
Taxonomic identifieri7454 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei5767. Ves v 3.
5768. Ves v 3.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000040192426 – 776Venom dipeptidyl peptidase 4Add BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi449 ↔ 452By similarity
Disulfide bondi462 ↔ 480By similarity
Glycosylationi504N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi577N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi658 ↔ 769By similarity
Glycosylationi688N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi693N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliB1A4F7.
SMRiB1A4F7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family. DPPIV subfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
PfamiView protein in Pfam
PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1A4F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPLRSFVLL NSLFLVLLAA RTVVTRVIDK DNSDRIVKTQ NDQNLSKVPF
60 70 80 90 100
NLEETYTADF LAYVFNGTWT SDTTIVYTDR RTGDILQFDV IKQRSTLIVD
110 120 130 140 150
SSVMDAYIVS NYVLSPKGRY LLIGYDLKKG YRYSTFMRYV IYDIEHRAYH
160 170 180 190 200
KIGNDMHIAL AKWAPLTDDL IYILDNDIYY MRFSNNGFND VQRVTYDGIS
210 220 230 240 250
GIVYNGVPDW VYEEEVLQDS SAIWFSPDGN HLAYASFDDR NVQEILYLHY
260 270 280 290 300
GEPGNLDDQY PTEVKIKYPK VGTLNPVVSL TLVDLHDPTL NKIDLKAPHY
310 320 330 340 350
AVGTDNLLYN VQWKDFDHVV VTWSNRVQNK TEIVWYNMYG EIVKTLHVVE
360 370 380 390 400
HKGWLDIKHL FFYKGSVYIR KLQPSGTKAG RFHHVTRYDE TFKQSPTQMD
410 420 430 440 450
LTPDAIEVQN ICTIDQSNGR IYYLASGLGK PSQKNLYSVP ADGSEKPTCI
460 470 480 490 500
SCNVLTPEGN VCTYADAIFS PLGQYYVLVC HGPDPAFVSI FNNAHQKVYS
510 520 530 540 550
WENNLSLRKK LAKRHLPLVK DLDVRANGYE SKVRLFLPHN FDESKSYPML
560 570 580 590 600
VNVYAGPNTL KIIDAASYGH QVYMTTNRSV IYAYIDGRGS SNKGSKMLFS
610 620 630 640 650
IYRKLGTVEV EDQITVTRQL QEMFPWIDSK RTGVWGWSYG GFSTAMILAK
660 670 680 690 700
DTSFVFKCGI AIAPVSSWIY YDSIYTERFM GFPTPEDNLS GYNETDVSRR
710 720 730 740 750
VEDIRGKKFM LIHGSGDDNV HYQQSLALAK ALEKADVMFE QITYTDEAHA
760 770
LFGVLPHLYH TMDRFWSDCF SLSHAH
Length:776
Mass (Da):88,924
Last modified:April 8, 2008 - v1
Checksum:i04A9ECBC4FFFC0B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU420987 mRNA. Translation: ACA00159.1.

Similar proteinsi

Entry informationi

Entry nameiVDDP4_VESVU
AccessioniPrimary (citable) accession number: B1A4F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: April 8, 2008
Last modified: September 27, 2017
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families