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B1A4F7

- VDDP4_VESVU

UniProt

B1A4F7 - VDDP4_VESVU

Protein

Venom dipeptidyl peptidase 4

Gene
N/A
Organism
Vespula vulgaris (Yellow jacket) (Wasp)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. May process venom proteins into their active forms and/or modulate the chemotactic activity of immune cells after the insect sting.1 Publication

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.1 Publication

    Enzyme regulationi

    Inhibited by diprotin A.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei638 – 6381Charge relay systemBy similarity
    Active sitei717 – 7171Charge relay systemBy similarity
    Active sitei749 – 7491Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Venom dipeptidyl peptidase 4 (EC:3.4.14.5)
    Alternative name(s):
    Venom dipeptidyl peptidase IV
    Allergen: Ves v 3
    OrganismiVespula vulgaris (Yellow jacket) (Wasp)
    Taxonomic identifieri7454 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.1 Publication

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei5767. Ves v 3.
    5768. Ves v 3.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 776751Venom dipeptidyl peptidase 4PRO_0000401924Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi449 ↔ 452By similarity
    Disulfide bondi462 ↔ 480By similarity
    Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi577 – 5771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi658 ↔ 769By similarity
    Glycosylationi688 – 6881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi693 – 6931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliB1A4F7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family. DPPIV subfamily.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B1A4F7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPLRSFVLL NSLFLVLLAA RTVVTRVIDK DNSDRIVKTQ NDQNLSKVPF    50
    NLEETYTADF LAYVFNGTWT SDTTIVYTDR RTGDILQFDV IKQRSTLIVD 100
    SSVMDAYIVS NYVLSPKGRY LLIGYDLKKG YRYSTFMRYV IYDIEHRAYH 150
    KIGNDMHIAL AKWAPLTDDL IYILDNDIYY MRFSNNGFND VQRVTYDGIS 200
    GIVYNGVPDW VYEEEVLQDS SAIWFSPDGN HLAYASFDDR NVQEILYLHY 250
    GEPGNLDDQY PTEVKIKYPK VGTLNPVVSL TLVDLHDPTL NKIDLKAPHY 300
    AVGTDNLLYN VQWKDFDHVV VTWSNRVQNK TEIVWYNMYG EIVKTLHVVE 350
    HKGWLDIKHL FFYKGSVYIR KLQPSGTKAG RFHHVTRYDE TFKQSPTQMD 400
    LTPDAIEVQN ICTIDQSNGR IYYLASGLGK PSQKNLYSVP ADGSEKPTCI 450
    SCNVLTPEGN VCTYADAIFS PLGQYYVLVC HGPDPAFVSI FNNAHQKVYS 500
    WENNLSLRKK LAKRHLPLVK DLDVRANGYE SKVRLFLPHN FDESKSYPML 550
    VNVYAGPNTL KIIDAASYGH QVYMTTNRSV IYAYIDGRGS SNKGSKMLFS 600
    IYRKLGTVEV EDQITVTRQL QEMFPWIDSK RTGVWGWSYG GFSTAMILAK 650
    DTSFVFKCGI AIAPVSSWIY YDSIYTERFM GFPTPEDNLS GYNETDVSRR 700
    VEDIRGKKFM LIHGSGDDNV HYQQSLALAK ALEKADVMFE QITYTDEAHA 750
    LFGVLPHLYH TMDRFWSDCF SLSHAH 776
    Length:776
    Mass (Da):88,924
    Last modified:April 8, 2008 - v1
    Checksum:i04A9ECBC4FFFC0B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU420987 mRNA. Translation: ACA00159.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU420987 mRNA. Translation: ACA00159.1 .

    3D structure databases

    ProteinModelPortali B1A4F7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 5767. Ves v 3.
    5768. Ves v 3.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification, recombinant expression, and characterization of the 100 kDa high molecular weight hymenoptera venom allergens Api m 5 and Ves v 3."
      Blank S., Seismann H., Bockisch B., Braren I., Cifuentes L., McIntyre M., Ruhl D., Ring J., Bredehorst R., Ollert M.W., Grunwald T., Spillner E.
      J. Immunol. 184:5403-5413(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 83-86; 301-309; 536-539; 548-555 AND 606-613, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALLERGEN.
      Tissue: Venom and Venom duct.

    Entry informationi

    Entry nameiVDDP4_VESVU
    AccessioniPrimary (citable) accession number: B1A4F7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 30, 2010
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3