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B1A4F7 (VDDP4_VESVU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Venom dipeptidyl peptidase 4

EC=3.4.14.5
Alternative name(s):
Venom dipeptidyl peptidase IV
Allergen=Ves v 3
OrganismVespula vulgaris (Yellow jacket) (Wasp)
Taxonomic identifier7454 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

Protein attributes

Sequence length776 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. May process venom proteins into their active forms and/or modulate the chemotactic activity of immune cells after the insect sting. Ref.1

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. Ref.1

Enzyme regulation

Inhibited by diprotin A. Ref.1

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed by the venom gland. Ref.1

Allergenic properties

Causes an allergic reaction in human. Ref.1

Sequence similarities

Belongs to the peptidase S9B family. DPPIV subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainSignal
   Molecular functionAminopeptidase
Hydrolase
Protease
   PTMDisulfide bond
Glycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 776751Venom dipeptidyl peptidase 4
PRO_0000401924

Sites

Active site6381Charge relay system By similarity
Active site7171Charge relay system By similarity
Active site7491Charge relay system By similarity

Amino acid modifications

Glycosylation441N-linked (GlcNAc...) Potential
Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation3291N-linked (GlcNAc...) Potential
Glycosylation5041N-linked (GlcNAc...) Potential
Glycosylation5771N-linked (GlcNAc...) Potential
Glycosylation6881N-linked (GlcNAc...) Potential
Glycosylation6931N-linked (GlcNAc...) Potential
Disulfide bond449 ↔ 452 By similarity
Disulfide bond462 ↔ 480 By similarity
Disulfide bond658 ↔ 769 By similarity

Sequences

Sequence LengthMass (Da)Tools
B1A4F7 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 04A9ECBC4FFFC0B2

FASTA77688,924
        10         20         30         40         50         60 
MVPLRSFVLL NSLFLVLLAA RTVVTRVIDK DNSDRIVKTQ NDQNLSKVPF NLEETYTADF 

        70         80         90        100        110        120 
LAYVFNGTWT SDTTIVYTDR RTGDILQFDV IKQRSTLIVD SSVMDAYIVS NYVLSPKGRY 

       130        140        150        160        170        180 
LLIGYDLKKG YRYSTFMRYV IYDIEHRAYH KIGNDMHIAL AKWAPLTDDL IYILDNDIYY 

       190        200        210        220        230        240 
MRFSNNGFND VQRVTYDGIS GIVYNGVPDW VYEEEVLQDS SAIWFSPDGN HLAYASFDDR 

       250        260        270        280        290        300 
NVQEILYLHY GEPGNLDDQY PTEVKIKYPK VGTLNPVVSL TLVDLHDPTL NKIDLKAPHY 

       310        320        330        340        350        360 
AVGTDNLLYN VQWKDFDHVV VTWSNRVQNK TEIVWYNMYG EIVKTLHVVE HKGWLDIKHL 

       370        380        390        400        410        420 
FFYKGSVYIR KLQPSGTKAG RFHHVTRYDE TFKQSPTQMD LTPDAIEVQN ICTIDQSNGR 

       430        440        450        460        470        480 
IYYLASGLGK PSQKNLYSVP ADGSEKPTCI SCNVLTPEGN VCTYADAIFS PLGQYYVLVC 

       490        500        510        520        530        540 
HGPDPAFVSI FNNAHQKVYS WENNLSLRKK LAKRHLPLVK DLDVRANGYE SKVRLFLPHN 

       550        560        570        580        590        600 
FDESKSYPML VNVYAGPNTL KIIDAASYGH QVYMTTNRSV IYAYIDGRGS SNKGSKMLFS 

       610        620        630        640        650        660 
IYRKLGTVEV EDQITVTRQL QEMFPWIDSK RTGVWGWSYG GFSTAMILAK DTSFVFKCGI 

       670        680        690        700        710        720 
AIAPVSSWIY YDSIYTERFM GFPTPEDNLS GYNETDVSRR VEDIRGKKFM LIHGSGDDNV 

       730        740        750        760        770 
HYQQSLALAK ALEKADVMFE QITYTDEAHA LFGVLPHLYH TMDRFWSDCF SLSHAH 

« Hide

References

[1]"Identification, recombinant expression, and characterization of the 100 kDa high molecular weight hymenoptera venom allergens Api m 5 and Ves v 3."
Blank S., Seismann H., Bockisch B., Braren I., Cifuentes L., McIntyre M., Ruhl D., Ring J., Bredehorst R., Ollert M.W., Grunwald T., Spillner E.
J. Immunol. 184:5403-5413(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 83-86; 301-309; 536-539; 548-555 AND 606-613, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALLERGEN.
Tissue: Venom and Venom duct.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU420987 mRNA. Translation: ACA00159.1.

3D structure databases

ProteinModelPortalB1A4F7.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome5767. Ves v 3.
5768. Ves v 3.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameVDDP4_VESVU
AccessionPrimary (citable) accession number: B1A4F7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: April 8, 2008
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Allergens

Nomenclature of allergens and list of entries