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B1A4F7

- VDDP4_VESVU

UniProt

B1A4F7 - VDDP4_VESVU

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Protein

Venom dipeptidyl peptidase 4

Gene
N/A
Organism
Vespula vulgaris (Yellow jacket) (Wasp)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. May process venom proteins into their active forms and/or modulate the chemotactic activity of immune cells after the insect sting.1 Publication

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.1 Publication

Enzyme regulationi

Inhibited by diprotin A.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei638 – 6381Charge relay system By similarity
Active sitei717 – 7171Charge relay system By similarity
Active sitei749 – 7491Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Venom dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Venom dipeptidyl peptidase IV
Allergen: Ves v 3
OrganismiVespula vulgaris (Yellow jacket) (Wasp)
Taxonomic identifieri7454 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaVespidaeVespinaeVespula

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei5767. Ves v 3.
5768. Ves v 3.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 776751Venom dipeptidyl peptidase 4PRO_0000401924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi66 – 661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi329 – 3291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi449 ↔ 452 By similarity
Disulfide bondi462 ↔ 480 By similarity
Glycosylationi504 – 5041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi577 – 5771N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi658 ↔ 769 By similarity
Glycosylationi688 – 6881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi693 – 6931N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliB1A4F7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1A4F7-1 [UniParc]FASTAAdd to Basket

« Hide

MVPLRSFVLL NSLFLVLLAA RTVVTRVIDK DNSDRIVKTQ NDQNLSKVPF    50
NLEETYTADF LAYVFNGTWT SDTTIVYTDR RTGDILQFDV IKQRSTLIVD 100
SSVMDAYIVS NYVLSPKGRY LLIGYDLKKG YRYSTFMRYV IYDIEHRAYH 150
KIGNDMHIAL AKWAPLTDDL IYILDNDIYY MRFSNNGFND VQRVTYDGIS 200
GIVYNGVPDW VYEEEVLQDS SAIWFSPDGN HLAYASFDDR NVQEILYLHY 250
GEPGNLDDQY PTEVKIKYPK VGTLNPVVSL TLVDLHDPTL NKIDLKAPHY 300
AVGTDNLLYN VQWKDFDHVV VTWSNRVQNK TEIVWYNMYG EIVKTLHVVE 350
HKGWLDIKHL FFYKGSVYIR KLQPSGTKAG RFHHVTRYDE TFKQSPTQMD 400
LTPDAIEVQN ICTIDQSNGR IYYLASGLGK PSQKNLYSVP ADGSEKPTCI 450
SCNVLTPEGN VCTYADAIFS PLGQYYVLVC HGPDPAFVSI FNNAHQKVYS 500
WENNLSLRKK LAKRHLPLVK DLDVRANGYE SKVRLFLPHN FDESKSYPML 550
VNVYAGPNTL KIIDAASYGH QVYMTTNRSV IYAYIDGRGS SNKGSKMLFS 600
IYRKLGTVEV EDQITVTRQL QEMFPWIDSK RTGVWGWSYG GFSTAMILAK 650
DTSFVFKCGI AIAPVSSWIY YDSIYTERFM GFPTPEDNLS GYNETDVSRR 700
VEDIRGKKFM LIHGSGDDNV HYQQSLALAK ALEKADVMFE QITYTDEAHA 750
LFGVLPHLYH TMDRFWSDCF SLSHAH 776
Length:776
Mass (Da):88,924
Last modified:April 8, 2008 - v1
Checksum:i04A9ECBC4FFFC0B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU420987 mRNA. Translation: ACA00159.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU420987 mRNA. Translation: ACA00159.1 .

3D structure databases

ProteinModelPortali B1A4F7.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 5767. Ves v 3.
5768. Ves v 3.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification, recombinant expression, and characterization of the 100 kDa high molecular weight hymenoptera venom allergens Api m 5 and Ves v 3."
    Blank S., Seismann H., Bockisch B., Braren I., Cifuentes L., McIntyre M., Ruhl D., Ring J., Bredehorst R., Ollert M.W., Grunwald T., Spillner E.
    J. Immunol. 184:5403-5413(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 83-86; 301-309; 536-539; 548-555 AND 606-613, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALLERGEN.
    Tissue: Venom and Venom duct.

Entry informationi

Entry nameiVDDP4_VESVU
AccessioniPrimary (citable) accession number: B1A4F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: April 8, 2008
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi