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Protein
Submitted name:

Forkhead box A2

Gene

FOXA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi165 – 259Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Forkhead box A2Imported
Submitted name:
Forkhead box A2, isoform CRA_bImported
Gene namesi
Name:FOXA2Imported
ORF Names:hCG_22162Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA201091.

Expressioni

Gene expression databases

BgeeiENSG00000125798.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000315955.

Structurei

3D structure databases

SMRiB0ZTD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 259Fork-head DNA-bindingInterPro annotationAdd BLAST95

Phylogenomic databases

eggNOGiKOG3563. Eukaryota.
COG5025. LUCA.
HOGENOMiHOG000231817.
HOVERGENiHBG006621.
OMAiQEHKRGG.
OrthoDBiEOG091G0HW9.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR013638. Fork-head_N.
IPR001766. Fork_head_dom.
IPR018533. Forkhead_box_C.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PF08430. Forkhead_N. 1 hit.
PF09354. HNF_C. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

B0ZTD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSASSMLGA VKMEGHEPSD WSSYYAEPEG YSSVSNMNAG LGMNGMNTYM
60 70 80 90 100
SMSAAAMGSG SGNMSAGSMN MSSYVGAGMS PSLAGMSPGA GAMAGMGGSA
110 120 130 140 150
GAAGVAGMGP HLSPSLSPLG GQAAGAMGGL APYANMNSMS PMYGQAGLSR
160 170 180 190 200
ARDPKTYRRS YTHAKPPYSY ISLITMAIQQ SPNKMLTLSE IYQWIMDLFP
210 220 230 240 250
FYRQNQQRWQ NSIRHSLSFN DCFLKVPRSP DKPGKGSFWT LHPDSGNMFE
260 270 280 290 300
NGCYLRRQKR FKCEKQLALK EAAGAAGSGK KAAAGAQASQ AQLGEAAGPA
310 320 330 340 350
SETPAGTESP HSSASPCQEH KRGGLGELKG TPAAALSPPE PAPSPGQQQQ
360 370 380 390 400
AAAHLLGPPH HPGLPPEAHL KPEHHYAFNH PFSINNLMSS EQQHHHSHHH
410 420 430 440 450
HQPHKMDLKA YEQVMHYPGY GSPMPGSLAM GPVTNKTGLD ASPLAADTSY
460
YQGVYSRPIM NSS
Length:463
Mass (Da):48,907
Last modified:April 8, 2008 - v1
Checksum:i726495A18CAE1677
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU402966 Genomic DNA. Translation: ACA06111.1.
CH471133 Genomic DNA. Translation: EAX10175.1.
RefSeqiNP_068556.2. NM_021784.4.
UniGeneiHs.155651.

Genome annotation databases

GeneIDi3170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU402966 Genomic DNA. Translation: ACA06111.1.
CH471133 Genomic DNA. Translation: EAX10175.1.
RefSeqiNP_068556.2. NM_021784.4.
UniGeneiHs.155651.

3D structure databases

SMRiB0ZTD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000315955.

Protocols and materials databases

DNASUi3170.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3170.

Organism-specific databases

CTDi3170.
PharmGKBiPA201091.

Phylogenomic databases

eggNOGiKOG3563. Eukaryota.
COG5025. LUCA.
HOGENOMiHOG000231817.
HOVERGENiHBG006621.
OMAiQEHKRGG.
OrthoDBiEOG091G0HW9.

Miscellaneous databases

ChiTaRSiFOXA2. human.
GenomeRNAii3170.

Gene expression databases

BgeeiENSG00000125798.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR013638. Fork-head_N.
IPR001766. Fork_head_dom.
IPR018533. Forkhead_box_C.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PF08430. Forkhead_N. 1 hit.
PF09354. HNF_C. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB0ZTD4_HUMAN
AccessioniPrimary (citable) accession number: B0ZTD4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 7, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.