B0YJ76 (B0YJ76_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dihydrofolate reductase EMBL ACA06052.1
EC=1.5.1.3 EMBL ABX57718.1

Submitted name:
cDNA, FLJ93028, Homo sapiens dihydrofolate reductase (DHFR), mRNA EMBL BAG35526.1

Gene names

Name:	DYR EMBL ACA06052.1
Synonyms:	DHFR EMBL ABX57718.1

Organism

Homo sapiens (Human) EMBL ACA06052.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Oxidoreductase EMBL ABX57718.1
Gene Ontology (GO)
Biological process	glycine biosynthetic process Inferred from electronic annotation. Source: InterPro nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro dihydrofolate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B0YJ76 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: EBDF3D1EC73E1566	FASTA	187	21,453
	10 20 30 40 50 60 MVGSLNCIVA VSQNMGIGKN GDLPWPPLRN EFRYFQRMTT TSSVEGKQNL VIMGKKTWFS 70 80 90 100 110 120 IPEKNRPLKG RINLVLSREL KEPPQGAHFL SRSLDDALKL TEQPELANKV DMVWIVGGSS 130 140 150 160 170 180 VYKEAMNHPG HLKLFVTRIM QDFESDTFFP EIDLEKYKLL PEYPGVLSDV QEEKGIKYKF EVYEKND

References

[1]	"Characterization and comparative studies of zebrafish and human recombinant dihydrofolate reductases--inhibition by folic acid and polyphenols." Kao T.T., Wang K.C., Chang W.N., Lin C.Y., Chen B.H., Wu H.L., Shi G.Y., Tsai J.N., Fu T.F. Drug Metab. Dispos. 36:508-516(2008) [PubMed: 18056255] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Stockwell T.B., Busam D.A., Ferriera S.M., Brownley A.N., Strausberg R.L., Kirkness E.F., Rogers Y.-H., Levy S. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Kao T.-T., Wang K.-C., Chang W.-N., Chen B.-H., Fu T.-F. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU145592 mRNA. Translation: ABX57718.1. EF445014 Genomic DNA. Translation: ACA06052.1. AK312642 mRNA. Translation: BAG35526.1.
IPI	IPI00030357.
RefSeq	NP_000782.1. NM_000791.3.
UniGene	Hs.592364. Hs.648635.
3D structure databases
ProteinModelPortal	B0YJ76.
SMR	B0YJ76. Positions 2-186.
ModBase	Search...
Protein-protein interaction databases
STRING	B0YJ76.
Proteomic databases
PRIDE	B0YJ76.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1719.
KEGG	hsa:1719.
UCSC	uc003kgx.1. human.
Organism-specific databases
CTD	1719.
PharmGKB	PA143.
Phylogenomic databases
HOVERGEN	HBG000773.
OMA	APNTFGY.
PhylomeDB	B0YJ76.
Gene expression databases
Bgee	B0YJ76.
Family and domain databases
InterPro	IPR012259. DHFR. IPR024072. DHFR-like_dom. IPR017925. DHFR_CS. IPR001796. DHFR_dom. [Graphical view]
Gene3D	G3DSA:3.40.430.10. G3DSA:3.40.430.10. 1 hit.
KO	K00287.
Pfam	PF00186. DHFR_1. 1 hit. [Graphical view]
PRINTS	PR00070. DHFR.
SUPFAM	SSF53597. SSF53597. 1 hit.
PROSITE	PS00075. DHFR_1. 1 hit. PS51330. DHFR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	6964.

Entry information

Entry name

B0YJ76_HUMAN

Accession

Primary (citable) accession number: B0YJ76

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	November 16, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.