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Protein
Submitted name:

Dihydrofolate reductase

Gene

DYR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydrofolate reductaseImported (EC:1.5.1.3Imported)
Submitted name:
cDNA, FLJ93028, Homo sapiens dihydrofolate reductase (DHFR), mRNAImported
Gene namesi
Name:DYRImported
Synonyms:DHFRImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143.

Expressioni

Gene expression databases

BgeeiENSG00000228716.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000396308.

Structurei

3D structure databases

SMRiB0YJ76. Positions 2-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 185182DHFR (dihydrofolate reductase)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1324. Eukaryota.
COG0262. LUCA.
HOGENOMiHOG000040235.
HOVERGENiHBG000773.
KOiK00287.
OMAiNGIKYEY.
OrthoDBiEOG091G0PRK.
PhylomeDBiB0YJ76.

Family and domain databases

CDDicd00209. DHFR. 1 hit.
Gene3Di3.40.430.10. 1 hit.
InterProiIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamiPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0YJ76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGSLNCIVA VSQNMGIGKN GDLPWPPLRN EFRYFQRMTT TSSVEGKQNL
60 70 80 90 100
VIMGKKTWFS IPEKNRPLKG RINLVLSREL KEPPQGAHFL SRSLDDALKL
110 120 130 140 150
TEQPELANKV DMVWIVGGSS VYKEAMNHPG HLKLFVTRIM QDFESDTFFP
160 170 180
EIDLEKYKLL PEYPGVLSDV QEEKGIKYKF EVYEKND
Length:187
Mass (Da):21,453
Last modified:April 8, 2008 - v1
Checksum:iEBDF3D1EC73E1566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU145592 mRNA. Translation: ABX57718.1.
EF445014 Genomic DNA. Translation: ACA06052.1.
AK312642 mRNA. Translation: BAG35526.1.
RefSeqiNP_000782.1. NM_000791.3.
UniGeneiHs.592364.
Hs.648635.

Genome annotation databases

GeneIDi1719.
KEGGihsa:1719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU145592 mRNA. Translation: ABX57718.1.
EF445014 Genomic DNA. Translation: ACA06052.1.
AK312642 mRNA. Translation: BAG35526.1.
RefSeqiNP_000782.1. NM_000791.3.
UniGeneiHs.592364.
Hs.648635.

3D structure databases

SMRiB0YJ76. Positions 2-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000396308.

Protocols and materials databases

DNASUi1719.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1719.
KEGGihsa:1719.

Organism-specific databases

CTDi1719.
PharmGKBiPA143.

Phylogenomic databases

eggNOGiKOG1324. Eukaryota.
COG0262. LUCA.
HOGENOMiHOG000040235.
HOVERGENiHBG000773.
KOiK00287.
OMAiNGIKYEY.
OrthoDBiEOG091G0PRK.
PhylomeDBiB0YJ76.

Miscellaneous databases

ChiTaRSiDHFR. human.
GenomeRNAii1719.

Gene expression databases

BgeeiENSG00000228716.

Family and domain databases

CDDicd00209. DHFR. 1 hit.
Gene3Di3.40.430.10. 1 hit.
InterProiIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamiPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 1 hit.
PROSITEiPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB0YJ76_HUMAN
AccessioniPrimary (citable) accession number: B0YJ76
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.