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Protein

Coatomer subunit delta

Gene

ARCN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.UniRule annotation

GO - Biological processi

Keywordsi

Biological processER-Golgi transportUniRule annotation, Protein transportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit deltaUniRule annotation
Gene namesi
Name:ARCN1Imported
ORF Names:hCG_40220Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cytoplasmic vesicleCOPI-coated vesicle membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Golgi apparatus membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation, Cytoplasmic vesicleUniRule annotation, Golgi apparatusUniRule annotation, MembraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24931.

Expressioni

Gene expression databases

BgeeiENSG00000095139.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi9606.ENSP00000264028.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini271 – 511MHD (mu homology)InterPro annotationAdd BLAST241

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili147 – 179Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2635. Eukaryota.
ENOG410XRH2. LUCA.
HOVERGENiHBG005381.
KOiK20471.

Family and domain databases

InterProiView protein in InterPro
IPR022775. AP_mu_sigma_su.
IPR027059. Coatomer_dsu.
IPR011012. Longin-like_dom.
IPR028565. MHD.
PANTHERiPTHR10121. PTHR10121. 1 hit.
PfamiView protein in Pfam
PF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiView protein in PROSITE
PS51072. MHD. 1 hit.

Sequencei

Sequence statusi: Complete.

B0YIW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE
60 70 80 90 100
TESVRYVYQP MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN
110 120 130 140 150
EISEHCFDLI FAFDEIVALG YRENVNLAQI RTFTEMDSHE EKVFRAVRET
160 170 180 190 200
QEREAKAEMR RKAKELQQAR RDAERQGKKA PGFGGFGSSA VSGGSTAAMI
210 220 230 240 250
TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD KLKSEGETIM
260 270 280 290 300
SSSMGKRTSE ATKMHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM
310 320 330 340 350
IMLRISDDKY GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE
360 370 380 390 400
KSFPVNSDVG VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED
410 420 430 440 450
NLELNDVVIT IPLPSGVGAP VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK
460 470 480 490 500
SGSLEFSIAG QPNDFFPVQV SFVSKKNYCN IQVTKVTQVD GNSPVRFSTE
510
TTFLVDKYEI L
Length:511
Mass (Da):57,210
Last modified:April 8, 2008 - v1
Checksum:i4ED1F7D2D12A7F75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF444951 Genomic DNA. Translation: ACA05943.1.
AK312298 mRNA. Translation: BAG35225.1.
CH471065 Genomic DNA. Translation: EAW67398.1.
CH471065 Genomic DNA. Translation: EAW67399.1.
RefSeqiNP_001646.2. NM_001655.4.
UniGeneiHs.33642.

Genome annotation databases

GeneIDi372.
KEGGihsa:372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF444951 Genomic DNA. Translation: ACA05943.1.
AK312298 mRNA. Translation: BAG35225.1.
CH471065 Genomic DNA. Translation: EAW67398.1.
CH471065 Genomic DNA. Translation: EAW67399.1.
RefSeqiNP_001646.2. NM_001655.4.
UniGeneiHs.33642.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000264028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi372.
KEGGihsa:372.

Organism-specific databases

CTDi372.
PharmGKBiPA24931.

Phylogenomic databases

eggNOGiKOG2635. Eukaryota.
ENOG410XRH2. LUCA.
HOVERGENiHBG005381.
KOiK20471.

Miscellaneous databases

ChiTaRSiARCN1. human.
GenomeRNAii372.

Gene expression databases

BgeeiENSG00000095139.

Family and domain databases

InterProiView protein in InterPro
IPR022775. AP_mu_sigma_su.
IPR027059. Coatomer_dsu.
IPR011012. Longin-like_dom.
IPR028565. MHD.
PANTHERiPTHR10121. PTHR10121. 1 hit.
PfamiView protein in Pfam
PF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiView protein in PROSITE
PS51072. MHD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB0YIW5_HUMAN
AccessioniPrimary (citable) accession number: B0YIW5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.