Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Type III neuregulin 1

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. protein tyrosine kinase activator activity Source: Ensembl
  2. transcription cofactor activity Source: Ensembl

GO - Biological processi

  1. cardiac muscle cell myoblast differentiation Source: Ensembl
  2. cell proliferation Source: Ensembl
  3. cellular protein complex disassembly Source: Ensembl
  4. endocardial cell differentiation Source: Ensembl
  5. ERBB signaling pathway Source: Ensembl
  6. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
  7. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  8. negative regulation of secretion Source: Ensembl
  9. negative regulation of transcription, DNA-templated Source: Ensembl
  10. positive regulation of cardiac muscle cell proliferation Source: Ensembl
  11. positive regulation of cell adhesion Source: Ensembl
  12. positive regulation of cell growth Source: Ensembl
  13. regulation of protein heterodimerization activity Source: Ensembl
  14. ventricular cardiac muscle cell differentiation Source: Ensembl
  15. ventricular trabecula myocardium morphogenesis Source: Ensembl
  16. wound healing Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_188191. Signaling by ERBB2.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188579. Signaling by ERBB4.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198574. Nuclear signaling by ERBB4.
REACT_199058. GRB7 events in ERBB2 signaling.
REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
REACT_203296. PI3K events in ERBB4 signaling.
REACT_215348. PI3K events in ERBB2 signaling.
REACT_226341. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Type III neuregulin 1Imported
Gene namesi
Name:Nrg1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. extracellular space Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiB0YIS0.

Expressioni

Gene expression databases

BgeeiB0YIS0.
ExpressionAtlasiB0YIS0. baseline.
GenevestigatoriB0YIS0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073546.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG47801.
HOVERGENiHBG006531.

Family and domain databases

InterProiIPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.

Sequencei

Sequence statusi: Fragment.

B0YIS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIYPPDMSE GAGGRSSSPS TQLSADPSLD GLPAAEHMPD THTEDGRSPG
60 70 80 90 100
LLGLAVPCCV CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV
110 120 130 140 150
DKIFEYDSPT HLDPGGLGQD PVISLDPTAA SAVLVSSEAY TSPVSKAQSE
160 170 180 190 200
AEAHVTGQGD HVAVASEPSA VPTRKNRLSA FPPLHSTPPP FPSPARTPEV
210 220
RTPKSGTQPQ TTETNLQTAP KL
Length:222
Mass (Da):23,230
Last modified:April 8, 2008 - v1
Checksum:iF7081ABCA27FF8EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei222 – 2221Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF410152 Genomic DNA. Translation: ABN79386.1.
UniGeneiMm.153432.
Mm.460675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF410152 Genomic DNA. Translation: ABN79386.1.
UniGeneiMm.153432.
Mm.460675.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073546.

Proteomic databases

PaxDbiB0YIS0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG47801.
HOVERGENiHBG006531.

Enzyme and pathway databases

ReactomeiREACT_188191. Signaling by ERBB2.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188579. Signaling by ERBB4.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198574. Nuclear signaling by ERBB4.
REACT_199058. GRB7 events in ERBB2 signaling.
REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
REACT_203296. PI3K events in ERBB4 signaling.
REACT_215348. PI3K events in ERBB2 signaling.
REACT_226341. PIP3 activates AKT signaling.

Miscellaneous databases

NextBioi35545604.

Gene expression databases

BgeeiB0YIS0.
ExpressionAtlasiB0YIS0. baseline.
GenevestigatoriB0YIS0.

Family and domain databases

InterProiIPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Type III Nrg1 is required for normal sensorimotor gating, memory related behaviors and cortico-striatal circuit components."
    Chen Y.-J.J., Johnson M.A., Lieberman M.D., Goodchild R., Rosoklija G., Gingrich J.A., Moore H., Dwork A.J., Talmage D.A., Role L.W.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvEv x C57BL/6Imported.

Entry informationi

Entry nameiB0YIS0_MOUSE
AccessioniPrimary (citable) accession number: B0YIS0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 7, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.