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B0YIS0

- B0YIS0_MOUSE

UniProt

B0YIS0 - B0YIS0_MOUSE

Protein
Submitted name:

Type III neuregulin 1

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein tyrosine kinase activator activity Source: Ensembl
    2. transcription cofactor activity Source: Ensembl

    GO - Biological processi

    1. cardiac muscle cell myoblast differentiation Source: Ensembl
    2. cell proliferation Source: Ensembl
    3. cellular protein complex disassembly Source: Ensembl
    4. endocardial cell differentiation Source: Ensembl
    5. ERBB signaling pathway Source: Ensembl
    6. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
    7. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    8. negative regulation of secretion Source: Ensembl
    9. negative regulation of transcription, DNA-templated Source: Ensembl
    10. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    11. positive regulation of cell adhesion Source: Ensembl
    12. positive regulation of cell growth Source: Ensembl
    13. regulation of protein heterodimerization activity Source: Ensembl
    14. ventricular cardiac muscle cell differentiation Source: Ensembl
    15. ventricular trabecula myocardium morphogenesis Source: Ensembl
    16. wound healing Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_188191. Signaling by ERBB2.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188579. Signaling by ERBB4.
    REACT_188580. SHC1 events in ERBB4 signaling.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198574. Nuclear signaling by ERBB4.
    REACT_199058. GRB7 events in ERBB2 signaling.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_203296. PI3K events in ERBB4 signaling.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Type III neuregulin 1Imported
    Gene namesi
    Name:Nrg1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. extracellular space Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PaxDbiB0YIS0.

    Expressioni

    Gene expression databases

    BgeeiB0YIS0.
    GenevestigatoriB0YIS0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000073546.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG47801.
    HOVERGENiHBG006531.
    InParanoidiB0YIS0.

    Sequencei

    Sequence statusi: Fragment.

    B0YIS0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIYPPDMSE GAGGRSSSPS TQLSADPSLD GLPAAEHMPD THTEDGRSPG    50
    LLGLAVPCCV CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV 100
    DKIFEYDSPT HLDPGGLGQD PVISLDPTAA SAVLVSSEAY TSPVSKAQSE 150
    AEAHVTGQGD HVAVASEPSA VPTRKNRLSA FPPLHSTPPP FPSPARTPEV 200
    RTPKSGTQPQ TTETNLQTAP KL 222
    Length:222
    Mass (Da):23,230
    Last modified:April 8, 2008 - v1
    Checksum:iF7081ABCA27FF8EA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei222 – 2221Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF410152 Genomic DNA. Translation: ABN79386.1.
    UniGeneiMm.153432.
    Mm.460675.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF410152 Genomic DNA. Translation: ABN79386.1 .
    UniGenei Mm.153432.
    Mm.460675.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000073546.

    Proteomic databases

    PaxDbi B0YIS0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG47801.
    HOVERGENi HBG006531.
    InParanoidi B0YIS0.

    Enzyme and pathway databases

    Reactomei REACT_188191. Signaling by ERBB2.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188579. Signaling by ERBB4.
    REACT_188580. SHC1 events in ERBB4 signaling.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198574. Nuclear signaling by ERBB4.
    REACT_199058. GRB7 events in ERBB2 signaling.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_203296. PI3K events in ERBB4 signaling.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Miscellaneous databases

    NextBioi 35545604.

    Gene expression databases

    Bgeei B0YIS0.
    Genevestigatori B0YIS0.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Type III Nrg1 is required for normal sensorimotor gating, memory related behaviors and cortico-striatal circuit components."
      Chen Y.-J.J., Johnson M.A., Lieberman M.D., Goodchild R., Rosoklija G., Gingrich J.A., Moore H., Dwork A.J., Talmage D.A., Role L.W.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvEv x C57BL/6Imported.

    Entry informationi

    Entry nameiB0YIS0_MOUSE
    AccessioniPrimary (citable) accession number: B0YIS0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)