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Protein

Probable beta-glucosidase E

Gene

bglE

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei446 – 4461By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase E (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase E
Cellobiase E
Gentiobiase E
Gene namesi
Name:bglE
ORF Names:AFUB_094720
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001699: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 161161CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei162 – 18221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini183 – 1033851ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10331033Probable beta-glucosidase EPRO_0000394871Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi489 – 4891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi593 – 5931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi909 – 9091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi918 – 9181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi976 – 9761N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB0YD91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000031215.
OrthoDBiEOG7HMS8F.
PhylomeDBiB0YD91.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

B0YD91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPPDSTHGG SFRDHLKTND RSSTSKGKQR YSPLQEAIPE EISSFRSPSE
60 70 80 90 100
YADTDSDSDL ERSGSYKLRP VDRYGSHHSS AFIPVIREEN GVETYLDSIT
110 120 130 140 150
EAEQELLSAS KQYDLVDDDD SSDFDSDEEA TLRYRLKDRL KRRRARLQAW
160 170 180 190 200
QPVKYARIWW RTLLAVVVTL VVVVWGFLSF AVSHREEPTV WPMVPSDSWF
210 220 230 240 250
PSPKGGTLKH WEESYKKAQS LVRNMTLVEK VNITTGIGWQ MGLCVGNTGP
260 270 280 290 300
ADIVKFPSLC LQDGPQGLRF ADHVSAFPAG ITTGSTWNRE LMRERGVAMG
310 320 330 340 350
REARLKGVNV LLGPSMGPLG MMPAGGRNWE GFGSDPVLQA VAAAETIRGI
360 370 380 390 400
QSNGVMATAK HFVMNEQEHF RQPFEWGIPT ALSSNVGDRA LHEVFAWPFA
410 420 430 440 450
ESIRADVASV MCSYQMVNNS HACENSKLLN GILKDELGFQ GFVQSDWLAQ
460 470 480 490 500
RSGINSALGG LDMSMPGDGL HWVDGKSLWG SELTRAVLNT SVPVERLNDM
510 520 530 540 550
VTRIVAAWYH LGQDTWERPP PEGNGGPNFS SWTNDEVGWL HTGSNDGSYA
560 570 580 590 600
RVNHYVDAQG TGPEAHSIIA RKVAAEGTVL LKNVDRTLPL SRNASSPSGG
610 620 630 640 650
ILRVGIYGDD AGPALGPNAC PDRGCNQGTL ATGWGSGTVE FPYLVSPIEA
660 670 680 690 700
LESAWSTEIE STAYLRNAVM PADAVDKDLC LVFVNADSGE GYISAGGIHG
710 720 730 740 750
DRNDLFLQKG GDTLVRTVSS NCGGGQGKTV VVIHAVGPVV MESWIDLPGV
760 770 780 790 800
HAVLLANLPG QESGNALVDV LFGEVDASGR LPYTIGKSLE DYGPGAQVLY
810 820 830 840 850
EPNAPVPQVD FLDALYIDYR HFDRHNITPR FEFGFGLSYT TFELLDLSIS
860 870 880 890 900
PLQQKSRSVP PRPADAVAPP VYDISLPDPA SALFPAGFQP VFKYIYPYLS
910 920 930 940 950
NLDGTAPHNY SFYPKGYNET QRPSPAGGGA GGHPALYEEM VSVKLQVSNT
960 970 980 990 1000
GDRKGQEVVQ VYVSFPPDFP ERVLRNFTKI ELEPSERREV QMTLSRKDLS
1010 1020 1030
YWSTREQNWV MPEGKFQIWV GRSSRDLPLM GEY
Length:1,033
Mass (Da):113,423
Last modified:April 8, 2008 - v1
Checksum:i68768F797E72DE92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499602 Genomic DNA. Translation: EDP47625.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00009375; CADAFUBP00009206; CADAFUBG00009375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499602 Genomic DNA. Translation: EDP47625.1.

3D structure databases

ProteinModelPortaliB0YD91.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUBT00009375; CADAFUBP00009206; CADAFUBG00009375.

Phylogenomic databases

HOGENOMiHOG000031215.
OrthoDBiEOG7HMS8F.
PhylomeDBiB0YD91.

Enzyme and pathway databases

UniPathwayiUPA00696.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CEA10 / CBS 144.89 / FGSC A1163.

Entry informationi

Entry nameiBGLE_ASPFC
AccessioniPrimary (citable) accession number: B0YD91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 8, 2008
Last modified: January 7, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.