Reviewed, UniProtKB/Swiss-Prot B0Y9Z9 (3HAO1_ASPFC)

Names and origin

Protein names

Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase 1
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase 1
      Short name=HAD-1
    3-hydroxyanthranilate oxygenase 1
      Short name=3-HAO-1
    Biosynthesis of nicotinic acid protein 1-1

Gene names

Name:	bna1-1
ORF Names:	AFUB_082850

Organism

Aspergillus fumigatus (strain CEA10 / CBS 144.89 / FGSC A1163) (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

451804 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.
Catalytic activity	3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.
Cofactor	Fe2+ ion By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 3-HAO family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	3-hydroxyanthranilate 3,4-dioxygenase 1		PRO_0000361976
Sites
	Metal binding	54	1	Iron; catalytic By similarity
	Metal binding	60	1	Iron; catalytic By similarity
	Metal binding	102	1	Iron; catalytic By similarity
	Metal binding	131	1	Divalent metal cation By similarity
	Metal binding	134	1	Divalent metal cation By similarity
	Metal binding	168	1	Divalent metal cation By similarity
	Metal binding	171	1	Divalent metal cation By similarity
	Binding site	50	1	Dioxygen By similarity
	Binding site	60	1	Substrate By similarity
	Binding site	106	1	Substrate By similarity
	Binding site	116	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0Y9Z9-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 148D406C365727F7	FASTA	192	21,705
	10 20 30 40 50 60 MLPPALNIPK WLEENSHLLQ PPVNNYCVYH PSSPATAGYT VMIVGGPNAR TDYHINTTPE 70 80 90 100 110 120 FFYQYRGSML LKTVDTSVSP PVFQDIPIHE GSIFLLPANT PHCPVRFKDT VGVVMEQPRP 130 140 150 160 170 180 KDAVDTMLWF CKKCGEVVWE KRFVCTDLGT QVKEVVEEFA ADQEKRTCKA CGTIAETRYQ 190 EGEVVQPPRF LE

References

[1]

"Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus." Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J., Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H., Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M. , Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J., Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C., White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H., Wortman J.R., Jiang B., Denning D.W., Nierman W.C. PLoS Genet. 4:E1000046-E1000046(2008) [PubMed: 18404212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DS499600 Genomic DNA. Translation: EDP48842.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR010329. 3hydroanth_dOase. [Graphical view]
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
TIGRFAMs	TIGR03037. anthran_nbaC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

3HAO1_ASPFC

Accession

Primary (citable) accession number: B0Y9Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	April 8, 2008
Last modified:	September 22, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)