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B0Y7W2

- EXGD_ASPFC

UniProt

B0Y7W2 - EXGD_ASPFC

Protein

Probable glucan 1,3-beta-glucosidase D

Gene

exgD

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan By similarity.By similarity

    Catalytic activityi

    Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei599 – 5991Proton donorBy similarity
    Active sitei704 – 7041NucleophileBy similarity

    GO - Molecular functioni

    1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
    Alternative name(s):
    Exo-1,3-beta-glucanase D
    Gene namesi
    Name:exgD
    ORF Names:AFUB_075220
    OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
    Taxonomic identifieri451804 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001699: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 833833Probable glucan 1,3-beta-glucosidase DPRO_0000395162Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi332 – 3321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi383 – 3831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi560 – 5601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi638 – 6381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi671 – 6711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi691 – 6911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliB0Y7W2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 305305CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini327 – 833507ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei306 – 32621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi6 – 176171Arg-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000114462.
    OrthoDBiEOG7ZPNTV.
    PhylomeDBiB0Y7W2.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00150. Cellulase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0Y7W2-1 [UniParc]FASTAAdd to Basket

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    MPTHSRSRDR YGGRDSDREA RYDYDYARRR YATDDDDDYD DDELEHDLTE    50
    RRYRRDGYRP PRESRARGYY ERDAEGAADE ELLGNERDPG PRASRSYGDD 100
    YDARRREHSR AREAPRRSER HRDRDREGRS RRRAYEDDGR HRTRDGRRDR 150
    GRESDGEARR SRRREAGRET AARKHRSSDS TNSASHLLSA DALAKLGAQY 200
    EKEERRKREI AKDAAKAERK RQKKLAVVGE ETRALRDPPG ESHRDRTKAR 250
    VASGAYLEEG RSPEMRVRHR GGGGPAMEAR WRKEGSWGGT MDDSGGGRPF 300
    WKRKRWIGLG ALIIILVIVI PVAVVVSKKH DNKSDPADSQ GTSPGKSNLD 350
    GLSHDSIPAY AQGTYLDPWT WYDTTDFNVT FTNETVGGLS IMGLNSTWDD 400
    SARPNDNVPP LNEPFPYGSQ PIRGVNLGGW LSIEPFIVPS LFDSYSSVSG 450
    IIDEWTLSKR LGSSAASTLE KHYATFITEQ DFADIRDAGL DHVRIQYSYW 500
    AVATYDDDPY VAKISWRYLL RAIEYCRKYG LRVNLDPHGI PGSQNGWNHS 550
    GREGVIGWLN GTDGELNRNR SLAVHDSVSK FFAQDRYKNI VTIYGLVNEP 600
    LMLSLSIEDV LDWTTEATKL VQKNGITAYV ALHDGFLNLS KWKSMLKNRP 650
    DKMLLDTHQY TIFNTGQIGL NHTAKVNLIC NDWYNMIKEI NSTSTGWGPT 700
    ICGEWSQADT DCAKYLNNVG RGTRWEGTFS LTDSTQYCPT ADTGPPCSCA 750
    NANADVSKYS ADYKKFLQTY AEAQMSAFET GQGWFYWTWR TESAAQWSYR 800
    TAWKNGFMPA KAYAPSFRCG DAVPDFGDLP EYY 833
    Length:833
    Mass (Da):94,775
    Last modified:April 8, 2008 - v1
    Checksum:i6A08231B6A8A1855
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499599 Genomic DNA. Translation: EDP49493.1.

    Genome annotation databases

    EnsemblFungiiCADAFUBT00007462; CADAFUBP00007327; CADAFUBG00007462.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499599 Genomic DNA. Translation: EDP49493.1 .

    3D structure databases

    ProteinModelPortali B0Y7W2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUBT00007462 ; CADAFUBP00007327 ; CADAFUBG00007462 .

    Phylogenomic databases

    HOGENOMi HOG000114462.
    OrthoDBi EOG7ZPNTV.
    PhylomeDBi B0Y7W2.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR001547. Glyco_hydro_5.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00150. Cellulase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CEA10 / CBS 144.89 / FGSC A1163.

    Entry informationi

    Entry nameiEXGD_ASPFC
    AccessioniPrimary (citable) accession number: B0Y7W2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3