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B0Y7S2 (MANBA_ASPFC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-mannosidase A

EC=3.2.1.25
Alternative name(s):
Mannanase A
Short name=Mannase A
Gene names
Name:mndA
ORF Names:AFUB_074800
OrganismNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus) [Complete proteome]
Taxonomic identifier451804 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length926 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

Pathway

Glycan metabolism; N-glycan degradation.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmannan catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-mannosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 926905Beta-mannosidase A
PRO_0000394644

Sites

Active site4741Proton donor By similarity

Amino acid modifications

Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation2771N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) Potential
Glycosylation3421N-linked (GlcNAc...) Potential
Glycosylation5321N-linked (GlcNAc...) Potential
Glycosylation6031N-linked (GlcNAc...) Potential
Glycosylation6261N-linked (GlcNAc...) Potential
Glycosylation6531N-linked (GlcNAc...) Potential
Glycosylation7331N-linked (GlcNAc...) Potential
Glycosylation7561N-linked (GlcNAc...) Potential
Glycosylation7851N-linked (GlcNAc...) Potential
Glycosylation7931N-linked (GlcNAc...) Potential
Glycosylation8191N-linked (GlcNAc...) Potential
Glycosylation9051N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B0Y7S2 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 0926E59CD2AE6E7A

FASTA926103,736
        10         20         30         40         50         60 
MHVKAETVLA LLTPAPPSVV GQHVVDLSGD GWTLSSTALN RTVPGHLPSQ VHLDLFEAGV 

        70         80         90        100        110        120 
IDIMASMILT FVGLRMPIGR IPATRLKAYF ESTWLVFDGL DTFATITFCD QHVGSTDNQF 

       130        140        150        160        170        180 
RQHHFDVSQI LKECKQDPVL RINFGSAPNI ANTIAKSPDA EEWPPGVQIT NEYPNRWYIR 

       190        200        210        220        230        240 
KEQSDFGWDW GPAFAPVGPW KPSYIVQNSH AELYVLNTDI DIYRQGQINY LPPDQSQPWI 

       250        260        270        280        290        300 
VNASIDFLGP VPCKPSMSIE IKDAATGSVL SSGLLQNVTV SGKSITGTTT IDGDAPKLWW 

       310        320        330        340        350        360 
PSGMGKQNLY NVTITVQNDM KKSLAKVTKR TGFRTIFLNQ RNITDDQLAQ GIAPGANWHF 

       370        380        390        400        410        420 
EINGYEFYAK GSNIIPPDAF WPRVTQARMA RLFDAVTAGN QNMLRVWASG AYLHDFIYDL 

       430        440        450        460        470        480 
ADEKGILLWS EFQFSDALYP VNDAFLENVA AEVVYNVRRV NHHPSLALWA GGNEIESLML 

       490        500        510        520        530        540 
PMARRADPTG YSKYIGEYEK LYISLILPLV YENTRSITYS PSSTTEGYLY VNLSAPVPMA 

       550        560        570        580        590        600 
ERYSNTTPGS YYGDTDYYNY DTSVSFDYNH YPVGRFANEF GFHSMPSLQT WQQAVDPEDL 

       610        620        630        640        650        660 
QFNSSVVVLR NHHYTAGGLF TDNFKNSSKG MGEMTMGVEA YYPIPSKSDS VANFSAWCHA 

       670        680        690        700        710        720 
TQLFQADLYK SQIQFYRRGS GMPERQLGSL YWQLEDIWQA PTWAGIEYDG RWKVLHYVAR 

       730        740        750        760        770        780 
DIYQPIIVSP FWNYTTGRLE VYVTSDLWEP AQGTVNLTWV DLSGKSIANN AGTPETVSFT 

       790        800        810        820        830        840 
VGALNTTNIY TTNISELSLP DLKDSILILS LSGEGRLPNA SSKKAFVHQN HFTPVFPKDL 

       850        860        870        880        890        900 
SLKDPKLEVS YSPESRKFTV QATGGVSLYT WLDYPAGAVG YFEANAFVLL PGVPKEVSFV 

       910        920 
AQEGNVTDDW LQRVTVQSLW DQKVRD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS499599 Genomic DNA. Translation: EDP49453.1.

3D structure databases

ProteinModelPortalB0Y7S2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUBT00007420; CADAFUBP00007287; CADAFUBG00007420.

Phylogenomic databases

HOGENOMHOG000216059.
OrthoDBEOG78D7TH.
PhylomeDBB0Y7S2.

Enzyme and pathway databases

UniPathwayUPA00280.

Family and domain databases

Gene3D2.60.120.260. 2 hits.
2.60.40.320. 1 hit.
3.20.20.80. 2 hits.
InterProIPR008979. Galactose-bd-like.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR028369. Mannanase.
[Graphical view]
PANTHERPTHR10066:SF12. PTHR10066:SF12. 1 hit.
PfamPF00703. Glyco_hydro_2. 1 hit.
[Graphical view]
SUPFAMSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMANBA_ASPFC
AccessionPrimary (citable) accession number: B0Y7S2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries