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B0Y7Q2

- PMIP_ASPFC

UniProt

B0Y7Q2 - PMIP_ASPFC

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Protein
Mitochondrial intermediate peptidase
Gene
oct1, AFUB_074600
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi564 – 5641Zinc; catalytic By similarity
Active sitei565 – 5651 By similarity
Metal bindingi568 – 5681Zinc; catalytic By similarity
Metal bindingi571 – 5711Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct1
ORF Names:AFUB_074600
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001699: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4141Mitochondrion Reviewed prediction
Add
BLAST
Chaini42 – 801760Mitochondrial intermediate peptidase
PRO_0000338570Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB0Y7Q2.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076521.
OrthoDBiEOG71GB4R.
PhylomeDBiB0Y7Q2.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0Y7Q2-1 [UniParc]FASTAAdd to Basket

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MKDQLLVPLR RRPWTCQKCL QRLQLPRHQT RRSFETAASP FPRPLDSLPA    50
DYARTKTVDD DTLRRVFDSQ QFWREFSQQR AAQPKPTGLV QNQYLTSPDG 100
FRTFANVSLQ KCQAIVSKVL AASTLEEYRT MARDLDRLSD LLCRVIDLSD 150
FIRVIHPDPQ VQEAATQAYA LMFEYMNVLN TTTGLNDQLK KAAANPEVTS 200
QWSDEEKIVA QILIKDFSNS AIHMPPHERQ RFVNLSNDIS QLGSSFVNGA 250
EPAKSHVSVA TNNLRGLDPI LVQQIKRWNR TAAVPTTGMI PRLALRSVHD 300
ENVRREVYLA SRTSSKRQLH RLEELLLKRA ELAKLSGYES FAHMTLSDKM 350
AKSPEAVSNF LTALVESNRK LVREELSQLQ VMKGAPLQPW DHAYYVHQRV 400
LQYSQARRSR ELSAVPEFFS LGTVMQGLSR LFDRLYGVRL VPQEPAPGET 450
WNPDVRRLDV VDEAGRHIAV IYCDLFSRPN KHPNPAHFTL RCSREISAEE 500
VAECASLDQS SHPNDGMATA VDPVTQTLRQ LPTIALVCDF PEPGTNGGGR 550
PSLLSEHSVR TLFHEMGHAV HSILGQTRLQ SISGTRCATD FAELPSVLME 600
HFATAPSVLA LYARHWRTDE PLSEGMIRSM ERDRTAHGSI YGAVENEAQI 650
LMALVDQAYH SRPADGGRID STALYQQVSQ QHSSLPEPAD ATTPPTSWQG 700
FFGHLYGYGA TYYSYIFDRA IANKLWVDVF GAGRHAVDRA AGERYKNEVL 750
RWGGGRSGWE CVAGALGSAN ESNADGRLVE GGDQAMREVG RWGLGRDGVS 800
G 801
Length:801
Mass (Da):89,667
Last modified:April 8, 2008 - v1
Checksum:i4EAE66D5ECCD8269
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS499599 Genomic DNA. Translation: EDP49433.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00007400; CADAFUBP00007267; CADAFUBG00007400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS499599 Genomic DNA. Translation: EDP49433.1 .

3D structure databases

ProteinModelPortali B0Y7Q2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUBT00007400 ; CADAFUBP00007267 ; CADAFUBG00007400 .

Phylogenomic databases

HOGENOMi HOG000076521.
OrthoDBi EOG71GB4R.
PhylomeDBi B0Y7Q2.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CEA10 / CBS 144.89 / FGSC A1163.

Entry informationi

Entry nameiPMIP_ASPFC
AccessioniPrimary (citable) accession number: B0Y7Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi