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B0Y7Q2

- PMIP_ASPFC

UniProt

B0Y7Q2 - PMIP_ASPFC

Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi564 – 5641Zinc; catalyticPROSITE-ProRule annotation
    Active sitei565 – 5651PROSITE-ProRule annotation
    Metal bindingi568 – 5681Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi571 – 5711Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:oct1
    ORF Names:AFUB_074600
    OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
    Taxonomic identifieri451804 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001699: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4141MitochondrionSequence AnalysisAdd
    BLAST
    Chaini42 – 801760Mitochondrial intermediate peptidasePRO_0000338570Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliB0Y7Q2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOGENOMiHOG000076521.
    OrthoDBiEOG71GB4R.
    PhylomeDBiB0Y7Q2.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B0Y7Q2-1 [UniParc]FASTAAdd to Basket

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    MKDQLLVPLR RRPWTCQKCL QRLQLPRHQT RRSFETAASP FPRPLDSLPA    50
    DYARTKTVDD DTLRRVFDSQ QFWREFSQQR AAQPKPTGLV QNQYLTSPDG 100
    FRTFANVSLQ KCQAIVSKVL AASTLEEYRT MARDLDRLSD LLCRVIDLSD 150
    FIRVIHPDPQ VQEAATQAYA LMFEYMNVLN TTTGLNDQLK KAAANPEVTS 200
    QWSDEEKIVA QILIKDFSNS AIHMPPHERQ RFVNLSNDIS QLGSSFVNGA 250
    EPAKSHVSVA TNNLRGLDPI LVQQIKRWNR TAAVPTTGMI PRLALRSVHD 300
    ENVRREVYLA SRTSSKRQLH RLEELLLKRA ELAKLSGYES FAHMTLSDKM 350
    AKSPEAVSNF LTALVESNRK LVREELSQLQ VMKGAPLQPW DHAYYVHQRV 400
    LQYSQARRSR ELSAVPEFFS LGTVMQGLSR LFDRLYGVRL VPQEPAPGET 450
    WNPDVRRLDV VDEAGRHIAV IYCDLFSRPN KHPNPAHFTL RCSREISAEE 500
    VAECASLDQS SHPNDGMATA VDPVTQTLRQ LPTIALVCDF PEPGTNGGGR 550
    PSLLSEHSVR TLFHEMGHAV HSILGQTRLQ SISGTRCATD FAELPSVLME 600
    HFATAPSVLA LYARHWRTDE PLSEGMIRSM ERDRTAHGSI YGAVENEAQI 650
    LMALVDQAYH SRPADGGRID STALYQQVSQ QHSSLPEPAD ATTPPTSWQG 700
    FFGHLYGYGA TYYSYIFDRA IANKLWVDVF GAGRHAVDRA AGERYKNEVL 750
    RWGGGRSGWE CVAGALGSAN ESNADGRLVE GGDQAMREVG RWGLGRDGVS 800
    G 801
    Length:801
    Mass (Da):89,667
    Last modified:April 8, 2008 - v1
    Checksum:i4EAE66D5ECCD8269
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499599 Genomic DNA. Translation: EDP49433.1.

    Genome annotation databases

    EnsemblFungiiCADAFUBT00007400; CADAFUBP00007267; CADAFUBG00007400.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499599 Genomic DNA. Translation: EDP49433.1 .

    3D structure databases

    ProteinModelPortali B0Y7Q2.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUBT00007400 ; CADAFUBP00007267 ; CADAFUBG00007400 .

    Phylogenomic databases

    HOGENOMi HOG000076521.
    OrthoDBi EOG71GB4R.
    PhylomeDBi B0Y7Q2.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 1 hit.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CEA10 / CBS 144.89 / FGSC A1163.

    Entry informationi

    Entry nameiPMIP_ASPFC
    AccessioniPrimary (citable) accession number: B0Y7Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3