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B0Y752

- BGALC_ASPFC

UniProt

B0Y752 - BGALC_ASPFC

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Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821SubstrateBy similarity
Binding sitei127 – 1271SubstrateBy similarity
Binding sitei128 – 1281Substrate; via amide nitrogenBy similarity
Binding sitei129 – 1291SubstrateBy similarity
Binding sitei187 – 1871SubstrateBy similarity
Active sitei188 – 1881Proton donorSequence Analysis
Binding sitei251 – 2511SubstrateBy similarity
Active sitei287 – 2871NucleophileSequence Analysis
Binding sitei353 – 3531SubstrateBy similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:AFUB_072590
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001699: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 983960Probable beta-galactosidase CPRO_0000395235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi257 ↔ 304By similarity
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi466 – 4661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi516 – 5161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi601 – 6011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi676 – 6761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi714 – 7141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi719 – 7191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi758 – 7581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi804 – 8041N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB0Y752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000181922.
OrthoDBiEOG7ZGXBD.
PhylomeDBiB0Y752.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0Y752-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIFSFLFLL LLGILTGQGL VSGTDNGKTT DVTWDKYSLS VKGQRLFVFS
60 70 80 90 100
GEFHYQRLPV PELWLDVFQK LRANGFNAIS VYFFWSFHSA SEGEFDFENG
110 120 130 140 150
AHDIQRLFDY AKEAGLYVIA RAGPYCNAET SAGGFALWAA NGQMGNERTS
160 170 180 190 200
DEAYYEKWRP WILEVGKIIA KNQITNGGPV ILNQHENELV ETTYDPNHTL
210 220 230 240 250
VVYMKQIAQV FEEAGIVVPS SHNEKGMRGV SWSTDYHNVG GAVNIYGLDS
260 270 280 290 300
YPGGLSCTNP NSGFNLVRTY HQWFQNYSFT QPSYLPEFEG GWFQPWGGSF
310 320 330 340 350
YDTCATELSP EFPDVYYKNN IGSRVTLHSI YMTYGGTNWG HSAAPVVYTS
360 370 380 390 400
YDYAAPLRET REIRDKLKQT KLIGLFTRVS KDLLKTYMEG NGTGYTSDSS
410 420 430 440 450
IYTWSLRNPD TNAGFYVLAH STSSTRDVTT FTLNVTTSAG AISIPDIELN
460 470 480 490 500
GRQSKIIVTD YNFGTNSTLL FSSAEVLTYA NLDVNVLVFY LNVGQKGTFV
510 520 530 540 550
FKDEPKLAFQ TYGNSNLTTS ESSYGTQYSY TQGKGVTAVK FSNGVLAYFL
560 570 580 590 600
DKESAWNFFA PPTTSSPQVA PNEHILVQGP YLVRGASVNH GTVEITGDNA
610 620 630 640 650
NTTSIEVYTG NSQVKKIKWN GKTIETRKTA YGSLIGTAPG AEDVKIQLPS
660 670 680 690 700
LDSWKAQDTL PEIQPDYDDS KWTVCNKTTS VNAIAPLSLP VLYSGDYGYH
710 720 730 740 750
AGTKVYRGRF DGRNVTGANV TVQNGAAAGW AAWVNGQYAG GSAGSPNLAA
760 770 780 790 800
TSAVLTFNSS SLKDQDNVLT VVTDYTGHDQ NSVRPKGTQN PRGILGATLI
810 820 830 840 850
GGGNFTSWRI QGNAGGEKNI DPVRGPMNEG GLYGERMGWH LPGYKVPKSA
860 870 880 890 900
SKSSPLDGVS GAEGRFYTTT FKLKLDKDLD VPIGLQLGAP EGTKAVVQVF
910 920 930 940 950
MNGYQFGHYL PHTGPQSLFP FPPGVINNRG ENTLAISMWA LTDAGAKLDK
960 970 980
VELVAYGKYR SGFDFNQDWG YLQPGWKDRS QYA
Length:983
Mass (Da):108,035
Last modified:April 8, 2008 - v1
Checksum:i61D896C6685A50A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS499599 Genomic DNA. Translation: EDP49233.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00007199; CADAFUBP00007067; CADAFUBG00007199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS499599 Genomic DNA. Translation: EDP49233.1 .

3D structure databases

ProteinModelPortali B0Y752.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUBT00007199 ; CADAFUBP00007067 ; CADAFUBG00007199 .

Phylogenomic databases

HOGENOMi HOG000181922.
OrthoDBi EOG7ZGXBD.
PhylomeDBi B0Y752.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CEA10 / CBS 144.89 / FGSC A1163.

Entry informationi

Entry nameiBGALC_ASPFC
AccessioniPrimary (citable) accession number: B0Y752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3