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B0Y752

- BGALC_ASPFC

UniProt

B0Y752 - BGALC_ASPFC

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Protein
Probable beta-galactosidase C
Gene
lacC, AFUB_072590
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821Substrate By similarity
Binding sitei127 – 1271Substrate By similarity
Binding sitei128 – 1281Substrate; via amide nitrogen By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei187 – 1871Substrate By similarity
Active sitei188 – 1881Proton donor Reviewed prediction
Binding sitei251 – 2511Substrate By similarity
Active sitei287 – 2871Nucleophile Reviewed prediction
Binding sitei353 – 3531Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:AFUB_072590
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001699: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 983960Probable beta-galactosidase C
PRO_0000395235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi197 – 1971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi257 ↔ 304 By similarity
Glycosylationi276 – 2761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi391 – 3911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi434 – 4341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi466 – 4661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi516 – 5161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi601 – 6011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi676 – 6761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi714 – 7141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi719 – 7191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi758 – 7581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi804 – 8041N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB0Y752.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000181922.
OrthoDBiEOG7ZGXBD.
PhylomeDBiB0Y752.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0Y752-1 [UniParc]FASTAAdd to Basket

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MRIFSFLFLL LLGILTGQGL VSGTDNGKTT DVTWDKYSLS VKGQRLFVFS    50
GEFHYQRLPV PELWLDVFQK LRANGFNAIS VYFFWSFHSA SEGEFDFENG 100
AHDIQRLFDY AKEAGLYVIA RAGPYCNAET SAGGFALWAA NGQMGNERTS 150
DEAYYEKWRP WILEVGKIIA KNQITNGGPV ILNQHENELV ETTYDPNHTL 200
VVYMKQIAQV FEEAGIVVPS SHNEKGMRGV SWSTDYHNVG GAVNIYGLDS 250
YPGGLSCTNP NSGFNLVRTY HQWFQNYSFT QPSYLPEFEG GWFQPWGGSF 300
YDTCATELSP EFPDVYYKNN IGSRVTLHSI YMTYGGTNWG HSAAPVVYTS 350
YDYAAPLRET REIRDKLKQT KLIGLFTRVS KDLLKTYMEG NGTGYTSDSS 400
IYTWSLRNPD TNAGFYVLAH STSSTRDVTT FTLNVTTSAG AISIPDIELN 450
GRQSKIIVTD YNFGTNSTLL FSSAEVLTYA NLDVNVLVFY LNVGQKGTFV 500
FKDEPKLAFQ TYGNSNLTTS ESSYGTQYSY TQGKGVTAVK FSNGVLAYFL 550
DKESAWNFFA PPTTSSPQVA PNEHILVQGP YLVRGASVNH GTVEITGDNA 600
NTTSIEVYTG NSQVKKIKWN GKTIETRKTA YGSLIGTAPG AEDVKIQLPS 650
LDSWKAQDTL PEIQPDYDDS KWTVCNKTTS VNAIAPLSLP VLYSGDYGYH 700
AGTKVYRGRF DGRNVTGANV TVQNGAAAGW AAWVNGQYAG GSAGSPNLAA 750
TSAVLTFNSS SLKDQDNVLT VVTDYTGHDQ NSVRPKGTQN PRGILGATLI 800
GGGNFTSWRI QGNAGGEKNI DPVRGPMNEG GLYGERMGWH LPGYKVPKSA 850
SKSSPLDGVS GAEGRFYTTT FKLKLDKDLD VPIGLQLGAP EGTKAVVQVF 900
MNGYQFGHYL PHTGPQSLFP FPPGVINNRG ENTLAISMWA LTDAGAKLDK 950
VELVAYGKYR SGFDFNQDWG YLQPGWKDRS QYA 983
Length:983
Mass (Da):108,035
Last modified:April 8, 2008 - v1
Checksum:i61D896C6685A50A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS499599 Genomic DNA. Translation: EDP49233.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00007199; CADAFUBP00007067; CADAFUBG00007199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS499599 Genomic DNA. Translation: EDP49233.1 .

3D structure databases

ProteinModelPortali B0Y752.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUBT00007199 ; CADAFUBP00007067 ; CADAFUBG00007199 .

Phylogenomic databases

HOGENOMi HOG000181922.
OrthoDBi EOG7ZGXBD.
PhylomeDBi B0Y752.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CEA10 / CBS 144.89 / FGSC A1163.

Entry informationi

Entry nameiBGALC_ASPFC
AccessioniPrimary (citable) accession number: B0Y752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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