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B0Y6C5

- DPP4_ASPFC

UniProt

B0Y6C5 - DPP4_ASPFC

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Protein
Probable dipeptidyl peptidase 4
Gene
dpp4, AFUB_066450
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity.1 Publication

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Kineticsi

  1. KM=0.38 mM for Gly-Pro pNA and Ala-Pro pNA1 Publication
  2. KM=0.15 mM for Arg-Pro pNA

pH dependencei

Optimum pH is 6.7 to 7.0.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei613 – 6131Charge relay system By similarity
Active sitei690 – 6901Charge relay system By similarity
Active sitei725 – 7251Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Keywords - Biological processi

Virulence

Protein family/group databases

MEROPSiS09.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:dpp4
ORF Names:AFUB_066450
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001699: Unassembled WGS sequence

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414 Reviewed prediction
Add
BLAST
Chaini15 – 765751Probable dipeptidyl peptidase 4
PRO_0000397810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi78 – 781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi101 – 1011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi218 – 2181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi465 – 4651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi490 – 4901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi665 – 6651N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00007859.

Structurei

3D structure databases

ProteinModelPortaliB0Y6C5.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189891.
OrthoDBiEOG72VHFG.
PhylomeDBiB0Y6C5.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0Y6C5-1 [UniParc]FASTAAdd to Basket

« Hide

MKWSILLLVG CAAAIDVPRQ PYAPTGSGKK RLTFNETVVK RAISPSAISV    50
EWISTSEDGD YVYQDQDGSL KIQSIVTNHT QTLVPADKVP EDAYSYWIHP 100
NLSSVLWATN YTKQYRYSYF ADYFIQDVQS MKLRPLAPDQ SGDIQYAQWS 150
PTGDAIAFVR DNNVFVWTNA STSQITNDGG PDLFNGVPDW IYEEEILGDR 200
FALWFSPDGA YLAFLRFNET GVPTFTVPYY MDNEEIAPPY PRELELRYPK 250
VSQTNPTVEL NLLELRTGER TPVPIDAFDA KELIIGEVAW LTGKHDVVAV 300
KAFNRVQDRQ KVVAVDVASL RSKTISERDG TDGWLDNLLS MAYIGPIGES 350
KEEYYIDISD QSGWAHLWLF PVAGGEPIAL TKGEWEVTNI LSIDKPRQLV 400
YFLSTKHHST ERHLYSVSWK TKEITPLVDD TVPAVWSASF SSQGGYYILS 450
YRGPDVPYQD LYAINSTAPL RTITSNAAVL NALKEYTLPN ITYFELALPS 500
GETLNVMQRL PVKFSPKKKY PVLFTPYGGP GAQEVSKAWQ ALDFKAYIAS 550
DPELEYITWT VDNRGTGYKG RAFRCQVASR LGELEAADQV FAAQQAAKLP 600
YVDAQHIAIW GWSYGGYLTG KVIETDSGAF SLGVQTAPVS DWRFYDSMYT 650
ERYMKTLESN AAGYNASAIR KVAGYKNVRG GVLIQHGTGD DNVHFQNAAA 700
LVDTLVGAGV TPEKLQVQWF TDSDHGIRYH GGNVFLYRQL SKRLYEEKKR 750
KEKGEAHQWS KKSVL 765
Length:765
Mass (Da):85,876
Last modified:April 8, 2008 - v1
Checksum:i544F27B6134F9B1B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171Y → H in AAC34310. 1 Publication
Sequence conflicti161 – 1611D → G in AAC34310. 1 Publication
Sequence conflicti538 – 5381A → P in AAC34310. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U87950 Genomic DNA. Translation: AAC34310.1.
DS499598 Genomic DNA. Translation: EDP50310.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00006595; CADAFUBP00006467; CADAFUBG00006595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U87950 Genomic DNA. Translation: AAC34310.1 .
DS499598 Genomic DNA. Translation: EDP50310.1 .

3D structure databases

ProteinModelPortali B0Y6C5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00007859.

Protein family/group databases

MEROPSi S09.008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUBT00006595 ; CADAFUBP00006467 ; CADAFUBG00006595 .

Phylogenomic databases

HOGENOMi HOG000189891.
OrthoDBi EOG72VHFG.
PhylomeDBi B0Y6C5.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dipeptidyl-peptidase IV secreted by Aspergillus fumigatus, a fungus pathogenic to humans."
    Beauvais A., Monod M., Wyniger J., Debeaupuis J.P., Grouzmann E., Brakch N., Svab J., Hovanessian A.G., Latge J.P.
    Infect. Immun. 65:3042-3047(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CEA10 / CBS 144.89 / FGSC A1163.

Entry informationi

Entry nameiDPP4_ASPFC
AccessioniPrimary (citable) accession number: B0Y6C5
Secondary accession number(s): O14425
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: April 8, 2008
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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