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B0Y6C5

- DPP4_ASPFC

UniProt

B0Y6C5 - DPP4_ASPFC

Protein

Probable dipeptidyl peptidase 4

Gene

dpp4

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity.1 Publication

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Kineticsi

    1. KM=0.38 mM for Gly-Pro pNA and Ala-Pro pNA1 Publication
    2. KM=0.15 mM for Arg-Pro pNA1 Publication

    pH dependencei

    Optimum pH is 6.7 to 7.0.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei613 – 6131Charge relay systemBy similarity
    Active sitei690 – 6901Charge relay systemBy similarity
    Active sitei725 – 7251Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Virulence

    Protein family/group databases

    MEROPSiS09.008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
    Alternative name(s):
    Dipeptidyl peptidase IV
    Short name:
    DPP IV
    Short name:
    DppIV
    Gene namesi
    Name:dpp4
    ORF Names:AFUB_066450
    OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
    Taxonomic identifieri451804 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001699: Unassembled WGS sequence

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1414Sequence AnalysisAdd
    BLAST
    Chaini15 – 765751Probable dipeptidyl peptidase 4PRO_0000397810Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00007859.

    Structurei

    3D structure databases

    ProteinModelPortaliB0Y6C5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000189891.
    OrthoDBiEOG72VHFG.
    PhylomeDBiB0Y6C5.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B0Y6C5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKWSILLLVG CAAAIDVPRQ PYAPTGSGKK RLTFNETVVK RAISPSAISV    50
    EWISTSEDGD YVYQDQDGSL KIQSIVTNHT QTLVPADKVP EDAYSYWIHP 100
    NLSSVLWATN YTKQYRYSYF ADYFIQDVQS MKLRPLAPDQ SGDIQYAQWS 150
    PTGDAIAFVR DNNVFVWTNA STSQITNDGG PDLFNGVPDW IYEEEILGDR 200
    FALWFSPDGA YLAFLRFNET GVPTFTVPYY MDNEEIAPPY PRELELRYPK 250
    VSQTNPTVEL NLLELRTGER TPVPIDAFDA KELIIGEVAW LTGKHDVVAV 300
    KAFNRVQDRQ KVVAVDVASL RSKTISERDG TDGWLDNLLS MAYIGPIGES 350
    KEEYYIDISD QSGWAHLWLF PVAGGEPIAL TKGEWEVTNI LSIDKPRQLV 400
    YFLSTKHHST ERHLYSVSWK TKEITPLVDD TVPAVWSASF SSQGGYYILS 450
    YRGPDVPYQD LYAINSTAPL RTITSNAAVL NALKEYTLPN ITYFELALPS 500
    GETLNVMQRL PVKFSPKKKY PVLFTPYGGP GAQEVSKAWQ ALDFKAYIAS 550
    DPELEYITWT VDNRGTGYKG RAFRCQVASR LGELEAADQV FAAQQAAKLP 600
    YVDAQHIAIW GWSYGGYLTG KVIETDSGAF SLGVQTAPVS DWRFYDSMYT 650
    ERYMKTLESN AAGYNASAIR KVAGYKNVRG GVLIQHGTGD DNVHFQNAAA 700
    LVDTLVGAGV TPEKLQVQWF TDSDHGIRYH GGNVFLYRQL SKRLYEEKKR 750
    KEKGEAHQWS KKSVL 765
    Length:765
    Mass (Da):85,876
    Last modified:April 8, 2008 - v1
    Checksum:i544F27B6134F9B1B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1171Y → H in AAC34310. (PubMed:9234752)Curated
    Sequence conflicti161 – 1611D → G in AAC34310. (PubMed:9234752)Curated
    Sequence conflicti538 – 5381A → P in AAC34310. (PubMed:9234752)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U87950 Genomic DNA. Translation: AAC34310.1.
    DS499598 Genomic DNA. Translation: EDP50310.1.

    Genome annotation databases

    EnsemblFungiiCADAFUBT00006595; CADAFUBP00006467; CADAFUBG00006595.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U87950 Genomic DNA. Translation: AAC34310.1 .
    DS499598 Genomic DNA. Translation: EDP50310.1 .

    3D structure databases

    ProteinModelPortali B0Y6C5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00007859.

    Protein family/group databases

    MEROPSi S09.008.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUBT00006595 ; CADAFUBP00006467 ; CADAFUBG00006595 .

    Phylogenomic databases

    HOGENOMi HOG000189891.
    OrthoDBi EOG72VHFG.
    PhylomeDBi B0Y6C5.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Dipeptidyl-peptidase IV secreted by Aspergillus fumigatus, a fungus pathogenic to humans."
      Beauvais A., Monod M., Wyniger J., Debeaupuis J.P., Grouzmann E., Brakch N., Svab J., Hovanessian A.G., Latge J.P.
      Infect. Immun. 65:3042-3047(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CEA10 / CBS 144.89 / FGSC A1163.

    Entry informationi

    Entry nameiDPP4_ASPFC
    AccessioniPrimary (citable) accession number: B0Y6C5
    Secondary accession number(s): O14425
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3