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B0Y5B4

- PDSA_ASPFC

UniProt

B0Y5B4 - PDSA_ASPFC

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Protein

Protostadienol synthase A

Gene

pdsA

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Protostadienol synthase which cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol), the biosynthetic precursor of helvolic acid, a secundary metabolite which promotes virulence.By similarity

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3-beta-ol.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei240 – 2401Proton acceptorBy similarity
Active sitei463 – 4631Proton donorBy similarity

GO - Molecular functioni

  1. intramolecular transferase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. steroid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Protostadienol synthase A (EC:5.4.99.32)
Gene namesi
Name:pdsA
ORF Names:AFUB_072030
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001699: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Protostadienol synthase APRO_0000415496Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB0Y5B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati132 – 17342PFTB 1Add
BLAST
Repeati490 – 53142PFTB 2Add
BLAST
Repeati567 – 60741PFTB 3Add
BLAST
Repeati616 – 66348PFTB 4Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 4 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000234317.
OrthoDBiEOG70610B.
PhylomeDBiB0Y5B4.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.

Sequencei

Sequence statusi: Complete.

B0Y5B4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATDSSMPGT VIGKAEFSDT KAASEFGTDL SRWRLNVDNG RHMWEYLESE
60 70 80 90 100
DEARKRPQSF LEKYWLGLPY ELPARPRATC ALEAVENGWE FFKRLQTADG
110 120 130 140 150
HWGCNDDGPL FVTSGMVIAR YIVGIPIDSH MKQEMCRYLL NVVNEDGGWG
160 170 180 190 200
LFIQSPSTVF GTVMNYCMLR ILGLGPEHPA MAKARNTLHR LGSARATPTW
210 220 230 240 250
GKFWLCVLGV YEWEGMVPLP PEPLLVPASL PFNPGKWWVH TRNVYISMSY
260 270 280 290 300
LYGHRFSMPP NKLVQALRDE LYDIPYQQIN WPAQRTNVSA ADRLTDPTWI
310 320 330 340 350
QRSFTSALTM YETFKIPFLR RRALNEALFQ IETETRNTHY LCIAPVSFAS
360 370 380 390 400
NMLALYHAHG RDSHWIRGMR DRFIDPMWLC REGLAASGTN GTSLWDTALT
410 420 430 440 450
VQATIDAGLA ARPENQAILR KALEFIDNSQ IREDPLGVHH VYRQPTRGAW
460 470 480 490 500
PFSTRDQSYA VSDTTAEAVK VIVLLQRIEG FPSRISDERL QQAIDLILGM
510 520 530 540 550
ENAGGGFSAY EPVRGPKFLE LLNITELYEN VMTDNLYPEC TSSVIMCLTT
560 570 580 590 600
FAREYPTYRP RDIQACLSRS IDYLLRSQYP NGGWFASWGV CFTYATMFAL
610 620 630 640 650
QGLACMGWNE SNCAACQRAC SFLLQHQNPD GGWGESLDTV RFKQYLPHPD
660 670 680 690 700
GSQVTNTAYA VIGLLAARCG NHEAIRRGVA YLVKEQQDTG EWLPGPLEGV
710 720 730
FAPPGGMRYP NYKFHFTLMA LGRYVAIHGN ECLAI
Length:735
Mass (Da):83,091
Last modified:April 8, 2008 - v1
Checksum:iAA0AC92A8A6E36F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499598 Genomic DNA. Translation: EDP50863.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00007152; CADAFUBP00007020; CADAFUBG00007152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499598 Genomic DNA. Translation: EDP50863.1 .

3D structure databases

ProteinModelPortali B0Y5B4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUBT00007152 ; CADAFUBP00007020 ; CADAFUBG00007152 .

Phylogenomic databases

HOGENOMi HOG000234317.
OrthoDBi EOG70610B.
PhylomeDBi B0Y5B4.

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CEA10 / CBS 144.89 / FGSC A1163.

Entry informationi

Entry nameiPDSA_ASPFC
AccessioniPrimary (citable) accession number: B0Y5B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 8, 2008
Last modified: October 1, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3