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B0Y5B4 (PDSA_ASPFC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protostadienol synthase A

EC=5.4.99.32
Gene names
Name:pdsA
ORF Names:AFUB_072030
OrganismNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus) [Complete proteome]
Taxonomic identifier451804 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length735 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protostadienol synthase which cyclizes (3S)-oxidosqualene to (17Z)-protosta-17(20),24-dien-3-beta-ol (protostadienol), the biosynthetic precursor of helvolic acid, a secundary metabolite which promotes virulence By similarity.

Catalytic activity

(3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3-beta-ol.

Sequence similarities

Belongs to the terpene cyclase/mutase family.

Contains 4 PFTB repeats.

Ontologies

Keywords
   Biological processLipid biosynthesis
Lipid metabolism
Steroid biosynthesis
Virulence
   DomainRepeat
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

steroid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionintramolecular transferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 735735Protostadienol synthase A
PRO_0000415496

Regions

Repeat132 – 17342PFTB 1
Repeat490 – 53142PFTB 2
Repeat567 – 60741PFTB 3
Repeat616 – 66348PFTB 4

Sites

Active site2401Proton acceptor By similarity
Active site4631Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
B0Y5B4 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: AA0AC92A8A6E36F8

FASTA73583,091
        10         20         30         40         50         60 
MATDSSMPGT VIGKAEFSDT KAASEFGTDL SRWRLNVDNG RHMWEYLESE DEARKRPQSF 

        70         80         90        100        110        120 
LEKYWLGLPY ELPARPRATC ALEAVENGWE FFKRLQTADG HWGCNDDGPL FVTSGMVIAR 

       130        140        150        160        170        180 
YIVGIPIDSH MKQEMCRYLL NVVNEDGGWG LFIQSPSTVF GTVMNYCMLR ILGLGPEHPA 

       190        200        210        220        230        240 
MAKARNTLHR LGSARATPTW GKFWLCVLGV YEWEGMVPLP PEPLLVPASL PFNPGKWWVH 

       250        260        270        280        290        300 
TRNVYISMSY LYGHRFSMPP NKLVQALRDE LYDIPYQQIN WPAQRTNVSA ADRLTDPTWI 

       310        320        330        340        350        360 
QRSFTSALTM YETFKIPFLR RRALNEALFQ IETETRNTHY LCIAPVSFAS NMLALYHAHG 

       370        380        390        400        410        420 
RDSHWIRGMR DRFIDPMWLC REGLAASGTN GTSLWDTALT VQATIDAGLA ARPENQAILR 

       430        440        450        460        470        480 
KALEFIDNSQ IREDPLGVHH VYRQPTRGAW PFSTRDQSYA VSDTTAEAVK VIVLLQRIEG 

       490        500        510        520        530        540 
FPSRISDERL QQAIDLILGM ENAGGGFSAY EPVRGPKFLE LLNITELYEN VMTDNLYPEC 

       550        560        570        580        590        600 
TSSVIMCLTT FAREYPTYRP RDIQACLSRS IDYLLRSQYP NGGWFASWGV CFTYATMFAL 

       610        620        630        640        650        660 
QGLACMGWNE SNCAACQRAC SFLLQHQNPD GGWGESLDTV RFKQYLPHPD GSQVTNTAYA 

       670        680        690        700        710        720 
VIGLLAARCG NHEAIRRGVA YLVKEQQDTG EWLPGPLEGV FAPPGGMRYP NYKFHFTLMA 

       730 
LGRYVAIHGN ECLAI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS499598 Genomic DNA. Translation: EDP50863.1.

3D structure databases

ProteinModelPortalB0Y5B4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUBT00007152; CADAFUBP00007020; CADAFUBG00007152.

Phylogenomic databases

HOGENOMHOG000234317.
OrthoDBEOG70610B.
PhylomeDBB0Y5B4.

Family and domain databases

Gene3D1.50.10.20. 2 hits.
InterProIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMSSF48239. SSF48239. 2 hits.
TIGRFAMsTIGR01787. squalene_cyclas. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDSA_ASPFC
AccessionPrimary (citable) accession number: B0Y5B4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families