Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B0Y4P5 (CREB_ASPFC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB

EC=3.4.19.12
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene names
Name:creB
ORF Names:AFUB_069810
OrganismNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus) [Complete proteome]
Taxonomic identifier451804 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length767 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with creA, creC and qutD By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 767767Probable ubiquitin carboxyl-terminal hydrolase creB
PRO_0000395678

Regions

Domain49 – 462414USP
Coiled coil574 – 64168 Potential
Compositional bias701 – 72626Gln-rich

Sites

Active site581Nucleophile By similarity
Active site4131Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
B0Y4P5 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: EFF2CE02A19E94D6

FASTA76786,762
        10         20         30         40         50         60 
MFCLLLGSTA PSVGAVPAKK EPQPPPMTPL EKRLLDMGPI REDGSDKFYG MENYGNTCYC 

        70         80         90        100        110        120 
NSILQCLYYS VPFREAVINY PTRTPIESLE AALAKSLRYP NPNAQLEAEA QAEKQKAANA 

       130        140        150        160        170        180 
QRPGMPPNPQ QKPEDKDSPE YKKKMALQTL PLLETQNNAS SYGMSESLFT SLKDIFESVV 

       190        200        210        220        230        240 
GSQSRIGIIR PQQFLEVLRR DHEMFRTAMH QDAHEFLNLL LNEVVANVEA EASKQPPIEK 

       250        260        270        280        290        300 
SLPAPETADS VDQSSSTGSK TPNTTRWVHE LFEGLLTSET QCLTCEKVSQ RDEVFLDLSV 

       310        320        330        340        350        360 
DLEQHSSVTS CLRKFSAEEM LCERNKFHCD NCGGLQEAEK RMKIKRLPRI LALHLKRFKY 

       370        380        390        400        410        420 
TEDLQRLQKL FHRVVYPYHL RLFNTTDDAE DPDRLYELYA VVVHIGGGPY HGHYVAIIKT 

       430        440        450        460        470        480 
EDRGWLLFDD EMVEPVDKNY VKNFFGDKPG LACAYVLFYQ ETTLEAVLKE QEQENMDSNL 

       490        500        510        520        530        540 
AATDANDTIL KQNGFPQSPL AHVHSASQIP SHEDNLRPNG LRRAPTAPQL STHHEHGDPE 

       550        560        570        580        590        600 
SAPFSPLSPL SPLSQTPPVP PVPERVTTVA TPPKNDALAK KERAREEKER KAAEKEREKA 

       610        620        630        640        650        660 
EKLRRKEQEA RMKENQRREE AELKAALEMS KASKAEEDRR LSHENGKEKQ GGSLSRLKRG 

       670        680        690        700        710        720 
SKSLSHRLGK DKETRSVSSD LPPVPIPEHS TLSQTGPTSE QQQQQQQQQQ QQQSPPNHDQ 

       730        740        750        760 
PPNSPQLGKP TIREDEQVNH KDSKHERTGH GKWRSFSLRK KSFSILS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS499598 Genomic DNA. Translation: EDP50644.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUBT00006929; CADAFUBP00006801; CADAFUBG00006929.

Phylogenomic databases

HOGENOMHOG000192482.
OrthoDBEOG7TF7JV.
PhylomeDBB0Y4P5.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCREB_ASPFC
AccessionPrimary (citable) accession number: B0Y4P5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries