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B0Y4P5

- CREB_ASPFC

UniProt

B0Y4P5 - CREB_ASPFC

Protein

Probable ubiquitin carboxyl-terminal hydrolase creB

Gene

creB

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei58 – 581NucleophilePROSITE-ProRule annotation
    Active sitei413 – 4131Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. carbon catabolite repression of transcription Source: UniProtKB
    2. ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
    Alternative name(s):
    Carbon catabolite repression protein B
    Deubiquitinating enzyme creB
    Ubiquitin thioesterase creB
    Ubiquitin-hydrolyzing enzyme creB
    Ubiquitin-specific-processing protease creB
    Gene namesi
    Name:creB
    ORF Names:AFUB_069810
    OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
    Taxonomic identifieri451804 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001699: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 767767Probable ubiquitin carboxyl-terminal hydrolase creBPRO_0000395678Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with creA, creC and qutD.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 462414USPAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili574 – 64168Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi701 – 72626Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    HOGENOMiHOG000192482.
    OrthoDBiEOG7TF7JV.
    PhylomeDBiB0Y4P5.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0Y4P5-1 [UniParc]FASTAAdd to Basket

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    MFCLLLGSTA PSVGAVPAKK EPQPPPMTPL EKRLLDMGPI REDGSDKFYG    50
    MENYGNTCYC NSILQCLYYS VPFREAVINY PTRTPIESLE AALAKSLRYP 100
    NPNAQLEAEA QAEKQKAANA QRPGMPPNPQ QKPEDKDSPE YKKKMALQTL 150
    PLLETQNNAS SYGMSESLFT SLKDIFESVV GSQSRIGIIR PQQFLEVLRR 200
    DHEMFRTAMH QDAHEFLNLL LNEVVANVEA EASKQPPIEK SLPAPETADS 250
    VDQSSSTGSK TPNTTRWVHE LFEGLLTSET QCLTCEKVSQ RDEVFLDLSV 300
    DLEQHSSVTS CLRKFSAEEM LCERNKFHCD NCGGLQEAEK RMKIKRLPRI 350
    LALHLKRFKY TEDLQRLQKL FHRVVYPYHL RLFNTTDDAE DPDRLYELYA 400
    VVVHIGGGPY HGHYVAIIKT EDRGWLLFDD EMVEPVDKNY VKNFFGDKPG 450
    LACAYVLFYQ ETTLEAVLKE QEQENMDSNL AATDANDTIL KQNGFPQSPL 500
    AHVHSASQIP SHEDNLRPNG LRRAPTAPQL STHHEHGDPE SAPFSPLSPL 550
    SPLSQTPPVP PVPERVTTVA TPPKNDALAK KERAREEKER KAAEKEREKA 600
    EKLRRKEQEA RMKENQRREE AELKAALEMS KASKAEEDRR LSHENGKEKQ 650
    GGSLSRLKRG SKSLSHRLGK DKETRSVSSD LPPVPIPEHS TLSQTGPTSE 700
    QQQQQQQQQQ QQQSPPNHDQ PPNSPQLGKP TIREDEQVNH KDSKHERTGH 750
    GKWRSFSLRK KSFSILS 767
    Length:767
    Mass (Da):86,762
    Last modified:April 8, 2008 - v1
    Checksum:iEFF2CE02A19E94D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499598 Genomic DNA. Translation: EDP50644.1.

    Genome annotation databases

    EnsemblFungiiCADAFUBT00006929; CADAFUBP00006801; CADAFUBG00006929.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499598 Genomic DNA. Translation: EDP50644.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUBT00006929 ; CADAFUBP00006801 ; CADAFUBG00006929 .

    Phylogenomic databases

    HOGENOMi HOG000192482.
    OrthoDBi EOG7TF7JV.
    PhylomeDBi B0Y4P5.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CEA10 / CBS 144.89 / FGSC A1163.

    Entry informationi

    Entry nameiCREB_ASPFC
    AccessioniPrimary (citable) accession number: B0Y4P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3