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B0Y4D5 (XKS1_ASPFC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable D-xylulose kinase A

Short name=Xylulokinase A
EC=2.7.1.17
Gene names
Name:xkiA
ORF Names:AFUB_057400
OrganismNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus) [Complete proteome]
Taxonomic identifier451804 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway By similarity.

Catalytic activity

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Subcellular location

Cytoplasm By similarity.

Induction

By D-xylose, L-arabinose or L-arabitol.

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Xylose metabolism
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

carbohydrate phosphorylation

Inferred from electronic annotation. Source: GOC

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xylulokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573Probable D-xylulose kinase A
PRO_0000393517

Regions

Nucleotide binding471 – 4722ATP By similarity

Sites

Binding site971Substrate By similarity
Binding site1681Substrate By similarity
Binding site2841Substrate By similarity
Binding site2851Substrate By similarity
Binding site3661ATP By similarity
Binding site4751ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B0Y4D5 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: FB1E317F57D2B829

FASTA57362,940
        10         20         30         40         50         60 
MTSQGPLYIG FDLSTQQLKG LVVNSELKVV HISKFDFDAD SHGFSIKKGV LTNEAEHEVF 

        70         80         90        100        110        120 
APVALWLQAL DGVLNGLRKQ GLDFSRVKGI SGAGQQHGSV YWGENAESLL KSLDSSKSLE 

       130        140        150        160        170        180 
EQLSGAFSHP FSPNWQDAST QKECDEFDAF LGGPEQLAEA TGSKAHHRFT GPQILRMQRK 

       190        200        210        220        230        240 
YPEVYKKTAR ISLVSSFLAS LLLGHIAPMD ISDVCGMNLW DIKKGAYNEK LLGLCAGPFG 

       250        260        270        280        290        300 
VEDLKRKLGA VPEDGGLRLG KINRYFVERY GFSSDCEILP STGDNPATIL ALPLRPSDAM 

       310        320        330        340        350        360 
VSLGTSTTFL MSTPNYKPDP ATHFFNHPTT PGLYMFMLCY KNGGLAREHV RDAINEKSGS 

       370        380        390        400        410        420 
GASQSWESFD KIMLETPPMG QKTESGPMKM GLFFPRPEIV PNVRSGQWRF TYDPASDALT 

       430        440        450        460        470        480 
ETEDGWNTPS DEARAIVESQ MLSLRLRSRG LTQSPGDGLP PQPRRVYLVG GGSKNKAIAK 

       490        500        510        520        530        540 
VAGEILGGSD GVYKLDVGDN ACALGAAYKA VWAIERKPGQ TFEDLIGQRW REEEFIEKIA 

       550        560        570 
DGYQKGVFEK YGKAVEGFEK MEQQVLKQEA ARK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS499597 Genomic DNA. Translation: EDP51726.1.

3D structure databases

ProteinModelPortalB0Y4D5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUBT00005719; CADAFUBP00005619; CADAFUBG00005719.

Phylogenomic databases

HOGENOMHOG000174850.
OrthoDBEOG7CRTZN.

Family and domain databases

InterProIPR018485. Carb_kinase_FGGY_C.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXKS1_ASPFC
AccessionPrimary (citable) accession number: B0Y4D5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 8, 2008
Last modified: February 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families