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Protein

Probable arabinan endo-1,5-alpha-L-arabinosidase A

Gene

abnA

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan (By similarity).By similarity

Catalytic activityi

Endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5)-arabinans.

Pathwayi: L-arabinan degradation

This protein is involved in the pathway L-arabinan degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway L-arabinan degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34Proton acceptorBy similarity1
Sitei149Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrateBy similarity1
Active sitei200Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00667.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arabinan endo-1,5-alpha-L-arabinosidase A (EC:3.2.1.99)
Alternative name(s):
Endo-1,5-alpha-L-arabinanase A
Short name:
ABN A
Gene namesi
Name:abnA
ORF Names:AFUB_034610
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000001699 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000039461820 – 321Probable arabinan endo-1,5-alpha-L-arabinosidase AAdd BLAST302

Structurei

3D structure databases

ProteinModelPortaliB0XZW5.
SMRiB0XZW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 43 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000292006.
OrthoDBiEOG092C2Y9R.
PhylomeDBiB0XZW5.

Family and domain databases

Gene3Di2.115.10.20. 2 hits.
InterProiView protein in InterPro
IPR006710. Glyco_hydro_43.
IPR016840. Glyco_hydro_43_endo_a_Ara-ase.
IPR023296. Glyco_hydro_beta-prop.
PfamiView protein in Pfam
PF04616. Glyco_hydro_43. 1 hit.
PIRSFiPIRSF026534. Endo_alpha-L-arabinosidase. 1 hit.
SUPFAMiSSF75005. SSF75005. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0XZW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASVFVVVA SCLAALAHGY ANPGSCLGAC NVHDPALIRR ESDGKYFRFS
60 70 80 90 100
TGNKISYASS SSIEGPWTVL GSVLPSGSSI DLPGNDDLWA PDVSLVNGVY
110 120 130 140 150
HVYYSVSTFG SQSSAIGLAT SSTMDLNSWT DHGSTGIQSS SSKPYNAIDG
160 170 180 190 200
NLFKDGGTYY MNFGSFWHDI YQAPMNSAAT SVASSSYNIA YNPSGTHAVE
210 220 230 240 250
GAFMYKYGNY YYLFFSAGIC CGYDTSRPAS GEEYKIKVCR STSATGNFVD
260 270 280 290 300
ANGVACTNGG GTVVLESHGN VYGPGGQGVF TDPSLGPILY YHYVDTTIGY
310 320
ADSQKLFGWN KIDFSSGWPV V
Length:321
Mass (Da):34,036
Last modified:April 8, 2008 - v1
Checksum:i9D9BFFE699F10574
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499596 Genomic DNA. Translation: EDP52297.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00003447; CADAFUBP00003385; CADAFUBG00003447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499596 Genomic DNA. Translation: EDP52297.1.

3D structure databases

ProteinModelPortaliB0XZW5.
SMRiB0XZW5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUBT00003447; CADAFUBP00003385; CADAFUBG00003447.

Phylogenomic databases

HOGENOMiHOG000292006.
OrthoDBiEOG092C2Y9R.
PhylomeDBiB0XZW5.

Enzyme and pathway databases

UniPathwayiUPA00667.

Family and domain databases

Gene3Di2.115.10.20. 2 hits.
InterProiView protein in InterPro
IPR006710. Glyco_hydro_43.
IPR016840. Glyco_hydro_43_endo_a_Ara-ase.
IPR023296. Glyco_hydro_beta-prop.
PfamiView protein in Pfam
PF04616. Glyco_hydro_43. 1 hit.
PIRSFiPIRSF026534. Endo_alpha-L-arabinosidase. 1 hit.
SUPFAMiSSF75005. SSF75005. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiABNA_ASPFC
AccessioniPrimary (citable) accession number: B0XZW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 8, 2008
Last modified: April 12, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.