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B0XZV8

- PLB3_ASPFC

UniProt

B0XZV8 - PLB3_ASPFC

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Protein
Lysophospholipase 3
Gene
plb3, AFUB_034540
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 3 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 3
Gene namesi
Name:plb3
ORF Names:AFUB_034540
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001699: Unassembled WGS sequence

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor 1 Publication

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Protein family/group databases

Allergomei8988. Asp f LPL3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 606590Lysophospholipase 3
PRO_0000372613Add
BLAST
Propeptidei607 – 63024Removed in mature form Reviewed prediction
PRO_0000372614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi351 – 3511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi390 – 3901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi456 – 4561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi462 – 4621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi493 – 4931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi514 – 5141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi542 – 5421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi566 – 5661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi583 – 5831N-linked (GlcNAc...) Reviewed prediction
Lipidationi606 – 6061GPI-like-anchor amidated asparagine Reviewed prediction

Post-translational modificationi

The GPI-like anchor contains a phosphoceramide lipid group.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Inductioni

Strongly induced by lecithin.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 587549PLA2c
Add
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.
Contains 1 PLA2c domain.

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189547.
OrthoDBiEOG7N37NC.
PhylomeDBiB0XZV8.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0XZV8-1 [UniParc]FASTAAdd to Basket

« Hide

MKALLSLLTA VAVATATPLD LSLRALPNAP DGYTPAKVSC PATRPSIRGA    50
GSLSPNETSW LEIRRKNTVQ PMTDLLGRLN LGFDAAGYID RVSSNASNLP 100
NIAIAVSGGG YRALTNGAGA IKAFDSRTQG STQSGHLGGL LQSATYVSGL 150
SGGGWLVGSV YLNNFTTIAD LQSGDHGNVW QFSTSILEGP KAKHLQFLST 200
ADYWKDLLKA VDGKSDAGFN TSLTDYWGRA LSYQFINDRT GNGGLSYTWS 250
SIALTDPFRR GEMPLPILVA DGRNPGELLI GSNSTVYEFN PWEFGSFDPS 300
IFGFAPLEYL GSRFDNGQLP RGEPCVRGFD NAGFVMGTSS SLFNQFILRL 350
NKTDLPDLAK DVFSKILTAI GRDGDDIAVY GPNPFYGYRN STAAYSRSRE 400
LDVVDGGEDG QNIPLHPLIQ PVRHVDVIFA VDSSADGPYS WPNGSALVAT 450
YERSLNSSGI GNGTVFPAVP DVNTFVNLGL NTRPTFFGCD PANLSAPAPL 500
VVYLPNAPYS THSNTSTFQL AYSDSERDEI ITNGYNVVTR GNATVDKSWP 550
SCVGCAILQR SMYRTNTSMP AVCNSCFKEY CWNGTVDSKT PRTYEPTLLL 600
GSTSTNAAYT QGVTWLVGIL AVGVAMGMTA 630
Length:630
Mass (Da):67,417
Last modified:April 8, 2008 - v1
Checksum:i0E83E7D7F149CA08
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701Q → E in AAQ85123. 1 Publication
Sequence conflicti542 – 5421N → D in AAQ85123. 1 Publication
Sequence conflicti618 – 6181G → S in AAQ85123. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY376593 mRNA. Translation: AAQ85123.1.
DS499596 Genomic DNA. Translation: EDP52290.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00003440; CADAFUBP00003378; CADAFUBG00003440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY376593 mRNA. Translation: AAQ85123.1 .
DS499596 Genomic DNA. Translation: EDP52290.1 .

3D structure databases

ModBasei Search...

Protein family/group databases

Allergomei 8988. Asp f LPL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUBT00003440 ; CADAFUBP00003378 ; CADAFUBG00003440 .

Phylogenomic databases

HOGENOMi HOG000189547.
OrthoDBi EOG7N37NC.
PhylomeDBi B0XZV8.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterisation and expression of phospholipases B from the opportunistic fungus Aspergillus fumigatus."
    Shen D.-K., Noodeh A.D., Kazemi A., Grillot R., Robson G.D., Brugere J.-F.
    FEMS Microbiol. Lett. 239:87-93(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CEA10 / CBS 144.89 / FGSC A1163.
  3. "Structures of the glycosylphosphatidylinositol membrane anchors from Aspergillus fumigatus membrane proteins."
    Fontaine T., Magnin T., Melhert A., Lamont D., Latge J.-P., Ferguson M.A.J.
    Glycobiology 13:169-177(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE OF GPI-ANCHOR.

Entry informationi

Entry nameiPLB3_ASPFC
AccessioniPrimary (citable) accession number: B0XZV8
Secondary accession number(s): Q4WYY4, Q6U819
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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