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B0XZV8

- PLB3_ASPFC

UniProt

B0XZV8 - PLB3_ASPFC

Protein

Lysophospholipase 3

Gene

plb3

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the release of fatty acids from lysophospholipids.

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phospholipid catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase 3 (EC:3.1.1.5)
    Alternative name(s):
    Phospholipase B 3
    Gene namesi
    Name:plb3
    ORF Names:AFUB_034540
    OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
    Taxonomic identifieri451804 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001699: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Protein family/group databases

    Allergomei8988. Asp f LPL3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 606590Lysophospholipase 3PRO_0000372613Add
    BLAST
    Propeptidei607 – 63024Removed in mature formSequence AnalysisPRO_0000372614Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi542 – 5421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi583 – 5831N-linked (GlcNAc...)Sequence Analysis
    Lipidationi606 – 6061GPI-like-anchor amidated asparagineSequence Analysis

    Post-translational modificationi

    The GPI-like anchor contains a phosphoceramide lipid group.

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Expressioni

    Inductioni

    Strongly induced by lecithin.1 Publication

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 587549PLA2cPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lysophospholipase family.Curated
    Contains 1 PLA2c domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000189547.
    OrthoDBiEOG7N37NC.
    PhylomeDBiB0XZV8.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view]
    PfamiPF01735. PLA2_B. 1 hit.
    [Graphical view]
    SMARTiSM00022. PLAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.
    PROSITEiPS51210. PLA2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B0XZV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKALLSLLTA VAVATATPLD LSLRALPNAP DGYTPAKVSC PATRPSIRGA    50
    GSLSPNETSW LEIRRKNTVQ PMTDLLGRLN LGFDAAGYID RVSSNASNLP 100
    NIAIAVSGGG YRALTNGAGA IKAFDSRTQG STQSGHLGGL LQSATYVSGL 150
    SGGGWLVGSV YLNNFTTIAD LQSGDHGNVW QFSTSILEGP KAKHLQFLST 200
    ADYWKDLLKA VDGKSDAGFN TSLTDYWGRA LSYQFINDRT GNGGLSYTWS 250
    SIALTDPFRR GEMPLPILVA DGRNPGELLI GSNSTVYEFN PWEFGSFDPS 300
    IFGFAPLEYL GSRFDNGQLP RGEPCVRGFD NAGFVMGTSS SLFNQFILRL 350
    NKTDLPDLAK DVFSKILTAI GRDGDDIAVY GPNPFYGYRN STAAYSRSRE 400
    LDVVDGGEDG QNIPLHPLIQ PVRHVDVIFA VDSSADGPYS WPNGSALVAT 450
    YERSLNSSGI GNGTVFPAVP DVNTFVNLGL NTRPTFFGCD PANLSAPAPL 500
    VVYLPNAPYS THSNTSTFQL AYSDSERDEI ITNGYNVVTR GNATVDKSWP 550
    SCVGCAILQR SMYRTNTSMP AVCNSCFKEY CWNGTVDSKT PRTYEPTLLL 600
    GSTSTNAAYT QGVTWLVGIL AVGVAMGMTA 630
    Length:630
    Mass (Da):67,417
    Last modified:April 8, 2008 - v1
    Checksum:i0E83E7D7F149CA08
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 701Q → E in AAQ85123. (PubMed:15451105)Curated
    Sequence conflicti542 – 5421N → D in AAQ85123. (PubMed:15451105)Curated
    Sequence conflicti618 – 6181G → S in AAQ85123. (PubMed:15451105)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY376593 mRNA. Translation: AAQ85123.1.
    DS499596 Genomic DNA. Translation: EDP52290.1.

    Genome annotation databases

    EnsemblFungiiCADAFUBT00003440; CADAFUBP00003378; CADAFUBG00003440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY376593 mRNA. Translation: AAQ85123.1 .
    DS499596 Genomic DNA. Translation: EDP52290.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 8988. Asp f LPL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUBT00003440 ; CADAFUBP00003378 ; CADAFUBG00003440 .

    Phylogenomic databases

    HOGENOMi HOG000189547.
    OrthoDBi EOG7N37NC.
    PhylomeDBi B0XZV8.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view ]
    Pfami PF01735. PLA2_B. 1 hit.
    [Graphical view ]
    SMARTi SM00022. PLAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    PROSITEi PS51210. PLA2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterisation and expression of phospholipases B from the opportunistic fungus Aspergillus fumigatus."
      Shen D.-K., Noodeh A.D., Kazemi A., Grillot R., Robson G.D., Brugere J.-F.
      FEMS Microbiol. Lett. 239:87-93(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CEA10 / CBS 144.89 / FGSC A1163.
    3. "Structures of the glycosylphosphatidylinositol membrane anchors from Aspergillus fumigatus membrane proteins."
      Fontaine T., Magnin T., Melhert A., Lamont D., Latge J.-P., Ferguson M.A.J.
      Glycobiology 13:169-177(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE OF GPI-ANCHOR.

    Entry informationi

    Entry nameiPLB3_ASPFC
    AccessioniPrimary (citable) accession number: B0XZV8
    Secondary accession number(s): Q4WYY4, Q6U819
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3