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B0XYK8

- DAPB_ASPFC

UniProt

B0XYK8 - DAPB_ASPFC

Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei757 – 7571Charge relay systemBy similarity
    Active sitei834 – 8341Charge relay systemBy similarity
    Active sitei867 – 8671Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    ORF Names:AFUB_041260
    OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
    Taxonomic identifieri451804 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001699: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 919919Probable dipeptidyl-aminopeptidase BPRO_0000412133Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi643 – 6431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi811 – 8111N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliB0XYK8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9292CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini114 – 919806VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei93 – 11321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000189891.
    OrthoDBiEOG72VHFG.
    PhylomeDBiB0XYK8.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0XYK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRSDGHEET SEFLPMTHSR SVSAASQTST DSSLSTESLF PREQKPFPNA    50
    MGGMALADDD KYRDLEDGEA ELSEPFLSSS KKAATGGGRA RRIFWILVLL 100
    CLGGWLLAFV LFLTGGRANY QTASDALQAH GADSALGSTS TSSGKPVTLQ 150
    QVLGGQWNPR YHAIGWVAGP NNEDGLLVEK GGDEKQGYLR VDDIRSRKGN 200
    NTGRESRVLM RKPIVHVDGQ AIVPSNVWPS PDLKKVLLIS EQQKNWRHSF 250
    TGKYWVFDVD SQTAQPLDPS APDGRVQLAL WSPASDAVVF VRDNNLYLRR 300
    LSSDSVVAIT KDGGENLFYG VPDWVYEEEV ISGNSVTWWS NDAKYIAFFR 350
    TNETSVPEFP VQYYISRPSG KKPLPGLENY PDVREIKYPK PGAPNPVVDL 400
    QFYDVEKNEV FSVQVADDFA DDDRIIIEVL WASEGKILVR STNRESDILK 450
    VYLIDTQSRT GKLVRSEDVA GLDGGWVEPS QSTRFVPADP NNGRPHDGYI 500
    DTVPYNGYDH LAYFSPLDNP NALMLTSGEW EVVDAPAAVD LQRGLVYFVG 550
    TKEAPTQRHV YRVQLDGSNL NPLTDTSKPG YYDVSFSHGT GYALLTYKGP 600
    SIPWQAIINT HGDEITYEDR IEDNAQLTKM VEAYALPTEV YQNVTVDGYT 650
    LQVVERRPPH FNPAKKYPVL FYLYGGPGSQ TVDRKFTVDF QSYVASSLGY 700
    IVVTVDGRGT GFIGRKARCI VRGNLGFYEA HDQIATAKMW AAKSYVDETR 750
    MAIWGWSFGG FMTLKTLEQD AGRTFQYGMA VAPVTDWRFY DSIYTERYMH 800
    TPQHNPNGYD NSTITDMAAL SESVRFLVMH GASDDNVHLQ NTLVLIDKLD 850
    LSNVENYDVQ FYPDSDHSIY FHNAHMMVYH RLSDWLVNAF NGEWHLIAKP 900
    VPDESMWERM KRSLRLLSP 919
    Length:919
    Mass (Da):103,089
    Last modified:April 8, 2008 - v1
    Checksum:iFF38600F2230B801
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499596 Genomic DNA. Translation: EDP52954.1.

    Genome annotation databases

    EnsemblFungiiCADAFUBT00004114; CADAFUBP00004042; CADAFUBG00004114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499596 Genomic DNA. Translation: EDP52954.1 .

    3D structure databases

    ProteinModelPortali B0XYK8.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUBT00004114 ; CADAFUBP00004042 ; CADAFUBG00004114 .

    Phylogenomic databases

    HOGENOMi HOG000189891.
    OrthoDBi EOG72VHFG.
    PhylomeDBi B0XYK8.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CEA10 / CBS 144.89 / FGSC A1163.

    Entry informationi

    Entry nameiDAPB_ASPFC
    AccessioniPrimary (citable) accession number: B0XYK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3