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B0XYK8

- DAPB_ASPFC

UniProt

B0XYK8 - DAPB_ASPFC

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
dapB, AFUB_041260
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei757 – 7571Charge relay system By similarity
Active sitei834 – 8341Charge relay system By similarity
Active sitei867 – 8671Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:AFUB_041260
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001699: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9292Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini114 – 919806Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 919919Probable dipeptidyl-aminopeptidase B
PRO_0000412133Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi352 – 3521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi643 – 6431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi811 – 8111N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB0XYK8.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
OrthoDBiEOG72VHFG.
PhylomeDBiB0XYK8.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B0XYK8-1 [UniParc]FASTAAdd to Basket

« Hide

MRRSDGHEET SEFLPMTHSR SVSAASQTST DSSLSTESLF PREQKPFPNA    50
MGGMALADDD KYRDLEDGEA ELSEPFLSSS KKAATGGGRA RRIFWILVLL 100
CLGGWLLAFV LFLTGGRANY QTASDALQAH GADSALGSTS TSSGKPVTLQ 150
QVLGGQWNPR YHAIGWVAGP NNEDGLLVEK GGDEKQGYLR VDDIRSRKGN 200
NTGRESRVLM RKPIVHVDGQ AIVPSNVWPS PDLKKVLLIS EQQKNWRHSF 250
TGKYWVFDVD SQTAQPLDPS APDGRVQLAL WSPASDAVVF VRDNNLYLRR 300
LSSDSVVAIT KDGGENLFYG VPDWVYEEEV ISGNSVTWWS NDAKYIAFFR 350
TNETSVPEFP VQYYISRPSG KKPLPGLENY PDVREIKYPK PGAPNPVVDL 400
QFYDVEKNEV FSVQVADDFA DDDRIIIEVL WASEGKILVR STNRESDILK 450
VYLIDTQSRT GKLVRSEDVA GLDGGWVEPS QSTRFVPADP NNGRPHDGYI 500
DTVPYNGYDH LAYFSPLDNP NALMLTSGEW EVVDAPAAVD LQRGLVYFVG 550
TKEAPTQRHV YRVQLDGSNL NPLTDTSKPG YYDVSFSHGT GYALLTYKGP 600
SIPWQAIINT HGDEITYEDR IEDNAQLTKM VEAYALPTEV YQNVTVDGYT 650
LQVVERRPPH FNPAKKYPVL FYLYGGPGSQ TVDRKFTVDF QSYVASSLGY 700
IVVTVDGRGT GFIGRKARCI VRGNLGFYEA HDQIATAKMW AAKSYVDETR 750
MAIWGWSFGG FMTLKTLEQD AGRTFQYGMA VAPVTDWRFY DSIYTERYMH 800
TPQHNPNGYD NSTITDMAAL SESVRFLVMH GASDDNVHLQ NTLVLIDKLD 850
LSNVENYDVQ FYPDSDHSIY FHNAHMMVYH RLSDWLVNAF NGEWHLIAKP 900
VPDESMWERM KRSLRLLSP 919
Length:919
Mass (Da):103,089
Last modified:April 8, 2008 - v1
Checksum:iFF38600F2230B801
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS499596 Genomic DNA. Translation: EDP52954.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00004114; CADAFUBP00004042; CADAFUBG00004114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS499596 Genomic DNA. Translation: EDP52954.1 .

3D structure databases

ProteinModelPortali B0XYK8.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUBT00004114 ; CADAFUBP00004042 ; CADAFUBG00004114 .

Phylogenomic databases

HOGENOMi HOG000189891.
OrthoDBi EOG72VHFG.
PhylomeDBi B0XYK8.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CEA10 / CBS 144.89 / FGSC A1163.

Entry informationi

Entry nameiDAPB_ASPFC
AccessioniPrimary (citable) accession number: B0XYK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 8, 2008
Last modified: June 11, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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