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Protein

Probable dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei757Charge relay systemBy similarity1
Active sitei834Charge relay systemBy similarity1
Active sitei867Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERiaspfu-q4wx13. DPP4N_Peptidase_S9.
MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:AFUB_041260
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000001699 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 92CytoplasmicSequence analysisAdd BLAST92
Transmembranei93 – 113Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini114 – 919VacuolarSequence analysisAdd BLAST806

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121331 – 919Probable dipeptidyl-aminopeptidase BAdd BLAST919

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Glycosylationi352N-linked (GlcNAc...)Sequence analysis1
Glycosylationi643N-linked (GlcNAc...)Sequence analysis1
Glycosylationi811N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiB0XYK8.

Structurei

3D structure databases

ProteinModelPortaliB0XYK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
OrthoDBiEOG092C0PZJ.
PhylomeDBiB0XYK8.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B0XYK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSDGHEET SEFLPMTHSR SVSAASQTST DSSLSTESLF PREQKPFPNA
60 70 80 90 100
MGGMALADDD KYRDLEDGEA ELSEPFLSSS KKAATGGGRA RRIFWILVLL
110 120 130 140 150
CLGGWLLAFV LFLTGGRANY QTASDALQAH GADSALGSTS TSSGKPVTLQ
160 170 180 190 200
QVLGGQWNPR YHAIGWVAGP NNEDGLLVEK GGDEKQGYLR VDDIRSRKGN
210 220 230 240 250
NTGRESRVLM RKPIVHVDGQ AIVPSNVWPS PDLKKVLLIS EQQKNWRHSF
260 270 280 290 300
TGKYWVFDVD SQTAQPLDPS APDGRVQLAL WSPASDAVVF VRDNNLYLRR
310 320 330 340 350
LSSDSVVAIT KDGGENLFYG VPDWVYEEEV ISGNSVTWWS NDAKYIAFFR
360 370 380 390 400
TNETSVPEFP VQYYISRPSG KKPLPGLENY PDVREIKYPK PGAPNPVVDL
410 420 430 440 450
QFYDVEKNEV FSVQVADDFA DDDRIIIEVL WASEGKILVR STNRESDILK
460 470 480 490 500
VYLIDTQSRT GKLVRSEDVA GLDGGWVEPS QSTRFVPADP NNGRPHDGYI
510 520 530 540 550
DTVPYNGYDH LAYFSPLDNP NALMLTSGEW EVVDAPAAVD LQRGLVYFVG
560 570 580 590 600
TKEAPTQRHV YRVQLDGSNL NPLTDTSKPG YYDVSFSHGT GYALLTYKGP
610 620 630 640 650
SIPWQAIINT HGDEITYEDR IEDNAQLTKM VEAYALPTEV YQNVTVDGYT
660 670 680 690 700
LQVVERRPPH FNPAKKYPVL FYLYGGPGSQ TVDRKFTVDF QSYVASSLGY
710 720 730 740 750
IVVTVDGRGT GFIGRKARCI VRGNLGFYEA HDQIATAKMW AAKSYVDETR
760 770 780 790 800
MAIWGWSFGG FMTLKTLEQD AGRTFQYGMA VAPVTDWRFY DSIYTERYMH
810 820 830 840 850
TPQHNPNGYD NSTITDMAAL SESVRFLVMH GASDDNVHLQ NTLVLIDKLD
860 870 880 890 900
LSNVENYDVQ FYPDSDHSIY FHNAHMMVYH RLSDWLVNAF NGEWHLIAKP
910
VPDESMWERM KRSLRLLSP
Length:919
Mass (Da):103,089
Last modified:April 8, 2008 - v1
Checksum:iFF38600F2230B801
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499596 Genomic DNA. Translation: EDP52954.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00004114; CADAFUBP00004042; CADAFUBG00004114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499596 Genomic DNA. Translation: EDP52954.1.

3D structure databases

ProteinModelPortaliB0XYK8.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiaspfu-q4wx13. DPP4N_Peptidase_S9.
MEROPSiS09.006.

Proteomic databases

PRIDEiB0XYK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUBT00004114; CADAFUBP00004042; CADAFUBG00004114.

Phylogenomic databases

HOGENOMiHOG000189891.
OrthoDBiEOG092C0PZJ.
PhylomeDBiB0XYK8.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDAPB_ASPFC
AccessioniPrimary (citable) accession number: B0XYK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 8, 2008
Last modified: October 5, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.