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B0XXF8 (EGLC_ASPFC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glucan endo-1,3-beta-glucosidase eglC

EC=3.2.1.39
Alternative name(s):
Endo-1,3-beta-glucanase eglC
Laminarinase eglC
Gene names
Name:eglC
ORF Names:AFUB_048180
OrganismNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus) [Complete proteome]
Taxonomic identifier451804 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase By similarity.

Catalytic activity

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity. Secretedcell wall By similarity. Note: Covalently-linked GPI-modified cell wall protein By similarity.

Post-translational modification

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 17 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 427409Probable glucan endo-1,3-beta-glucosidase eglC
PRO_0000395140
Propeptide428 – 45023Removed in mature form Potential
PRO_0000395141

Regions

Compositional bias309 – 435127Ser-rich

Sites

Active site1281Nucleophile By similarity
Active site2391Proton donor By similarity

Amino acid modifications

Lipidation4271GPI-anchor amidated asparagine Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation3621N-linked (GlcNAc...) Potential
Glycosylation3681N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
B0XXF8 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: F687F0613C6FA2B5

FASTA45044,943
        10         20         30         40         50         60 
MQFTHLVALA LALATSEAAH QGFNYGNTKS DGSAKSQADF QAEFSTAKNL VGTSGFTSAR 

        70         80         90        100        110        120 
LYTMIQGGTA NTPISAIPAA ITEQTSLLLG LWASGGNFAN EIAALKAAIA QYGDDLAKLV 

       130        140        150        160        170        180 
VGISVGSEDL YRNSVDGVKA NAGIGTNPDE IVSYINEVRS TIAGTKLSGA PIGHVDTWTA 

       190        200        210        220        230        240 
WVNGSNSAVI DACDWLGFDG YPYFQNTMAN SISDAKALFD ESVAKTQAVA KGKEVWITET 

       250        260        270        280        290        300 
GWPVSGKTEN LAVANLANAK TYWDEVGCPL FGKTNTWWYI LQDADPVTPN PSFGIVGSTL 

       310        320        330        340        350        360 
STTPLFDLSC SASSSSSAAA SSTAGPSASS VIGGKASGFT TAAANSAKPT FTVGKGPGGS 

       370        380        390        400        410        420 
YNGTGFWNST SSARPSSSAI SGSSSGSAAG SSGSSGSSGS GASGASGQSS SSTGSSSAPS 

       430        440        450 
TSNILSNAAS GLSGSICGAV VAVCLALAAL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS499596 Genomic DNA. Translation: EDP53632.1.

3D structure databases

ProteinModelPortalB0XXF8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUBT00004808; CADAFUBP00004720; CADAFUBG00004808.

Phylogenomic databases

HOGENOMHOG000179527.
OrthoDBEOG7TBCCK.
PhylomeDBB0XXF8.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEGLC_ASPFC
AccessionPrimary (citable) accession number: B0XXF8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries