ID   SCONB_ASPFC             Reviewed;         696 AA.
AC   B0XTS1;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=Probable E3 ubiquitin ligase complex SCF subunit sconB;
DE   AltName: Full=Sulfur controller B;
DE   AltName: Full=Sulfur metabolite repression control protein B;
GN   Name=sconB; ORFNames=AFUB_029730;
OS   Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10) (Neosartorya
OS   fumigata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 144.89 / FGSC A1163 / CEA10;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the SCF(sconB) E3 ubiquitin ligase complex
CC       involved in the regulation of sulfur metabolite repression, probably by
CC       mediating the inactivation or degradation of the metR transcription
CC       factor. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the SCF(sconB) E3 ubiquitin ligase complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
CC       {ECO:0000305}.
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DR   EMBL; DS499595; EDP54913.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0XTS1; -.
DR   SMR; B0XTS1; -.
DR   EnsemblFungi; EDP54913; EDP54913; AFUB_029730.
DR   VEuPathDB; FungiDB:AFUB_029730; -.
DR   HOGENOM; CLU_000288_103_1_1; -.
DR   PhylomeDB; B0XTS1; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd22147; F-box_SpPof1-like; 1.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19872; UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN; 1.
DR   PANTHER; PTHR19872:SF10; UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Repeat; Transcription; Transcription regulation; Ubl conjugation pathway;
KW   WD repeat.
FT   CHAIN           1..696
FT                   /note="Probable E3 ubiquitin ligase complex SCF subunit
FT                   sconB"
FT                   /id="PRO_0000397246"
FT   DOMAIN          193..239
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          365..402
FT                   /note="WD 1"
FT   REPEAT          405..444
FT                   /note="WD 2"
FT   REPEAT          446..482
FT                   /note="WD 3"
FT   REPEAT          484..525
FT                   /note="WD 4"
FT   REPEAT          579..622
FT                   /note="WD 5"
FT   REPEAT          623..662
FT                   /note="WD 6"
FT   REPEAT          665..696
FT                   /note="WD 7"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          554..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        554..584
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   696 AA;  77712 MW;  0377045046AA18C7 CRC64;
     MDAHELSFRD GHGSSTSTMK DGCASAEKPH YLPGDSSFTS VFGPSETVED VETEPGSTQD
     KPHSFNTQKP IRENLAGKNV APFLARHIPE QYAPLGSQGG QPVEISSANS KYCYRHRPDL
     KCRRQADEPT MDKLQRELET LPQSDQQGIA HAWSIFSAAP AKHRKLILQG IMAQCCFPQL
     SFISATVRDL IRIDFLTALP PEISFKILCY LDTTSLCKAA QVSRRWRALA DDDVVWHRMC
     EQHIHRKCKK CGWGLPLLDR KRLRESKREI ERRAATWDVS KQPAGIEGSS ATIETAAAGS
     KRKPESGKED TAMVKRQCTS IVSQSEQNED YFKTRYRPWK EVYKDRFKVG TNWKYGRCST
     RVFKGHSNGI MCLQFEDNIL ATGSYDATIK IWDTETGEEL RTLKGHQSGI RCLQFDDTKL
     ISGSMDHTLK VWNWRTGECI STYSGHRGGV VGLHFDATIL ASGSVDKTVK IWNFEDKSTC
     LLRGHTDWVN AVRVDSASRT VFSASDDCTV KLWDLDTKSC IRTFHGHVGQ VQQVVPLPRE
     FEFEDHDVEC ENDNVSVTSG DSPAASPQAL PGFDGQTSDT PSSAFGPAFD DGRPSPPRYI
     VTSALDSTIR LWETSSGRCL RTFFGHLEGV WALAADTLRI VSGAEDRMVK IWDPRTGKCE
     RTFTGHSGPV TCIGLGDSRF ATGSEDCEVR MYSFQT
//