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Protein

Probable E3 ubiquitin ligase complex SCF subunit sconB

Gene

sconB

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.By similarity

Pathwayi

GO - Biological processi

  1. DNA replication initiation Source: EnsemblFungi
  2. protein polyubiquitination Source: EnsemblFungi
  3. protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: EnsemblFungi
  4. regulation of DNA-dependent DNA replication initiation Source: EnsemblFungi
  5. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: EnsemblFungi
  6. response to arsenic-containing substance Source: EnsemblFungi
  7. response to cadmium ion Source: EnsemblFungi
  8. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: EnsemblFungi
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin ligase complex SCF subunit sconB
Alternative name(s):
Sulfur controller B
Sulfur metabolite repression control protein B
Gene namesi
Name:sconB
ORF Names:AFUB_029730
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001699 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. nuclear SCF ubiquitin ligase complex Source: EnsemblFungi
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Probable E3 ubiquitin ligase complex SCF subunit sconBPRO_0000397246Add
BLAST

Interactioni

Subunit structurei

Component of the SCF(sconB) E3 ubiquitin ligase complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliB0XTS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini193 – 23947F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati365 – 40238WD 1Add
BLAST
Repeati405 – 44440WD 2Add
BLAST
Repeati446 – 48237WD 3Add
BLAST
Repeati484 – 52542WD 4Add
BLAST
Repeati579 – 62244WD 5Add
BLAST
Repeati623 – 66240WD 6Add
BLAST
Repeati665 – 69632WD 7Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000166480.
OrthoDBiEOG7C5MHX.
PhylomeDBiB0XTS1.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF81383. SSF81383. 2 hits.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0XTS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAHELSFRD GHGSSTSTMK DGCASAEKPH YLPGDSSFTS VFGPSETVED
60 70 80 90 100
VETEPGSTQD KPHSFNTQKP IRENLAGKNV APFLARHIPE QYAPLGSQGG
110 120 130 140 150
QPVEISSANS KYCYRHRPDL KCRRQADEPT MDKLQRELET LPQSDQQGIA
160 170 180 190 200
HAWSIFSAAP AKHRKLILQG IMAQCCFPQL SFISATVRDL IRIDFLTALP
210 220 230 240 250
PEISFKILCY LDTTSLCKAA QVSRRWRALA DDDVVWHRMC EQHIHRKCKK
260 270 280 290 300
CGWGLPLLDR KRLRESKREI ERRAATWDVS KQPAGIEGSS ATIETAAAGS
310 320 330 340 350
KRKPESGKED TAMVKRQCTS IVSQSEQNED YFKTRYRPWK EVYKDRFKVG
360 370 380 390 400
TNWKYGRCST RVFKGHSNGI MCLQFEDNIL ATGSYDATIK IWDTETGEEL
410 420 430 440 450
RTLKGHQSGI RCLQFDDTKL ISGSMDHTLK VWNWRTGECI STYSGHRGGV
460 470 480 490 500
VGLHFDATIL ASGSVDKTVK IWNFEDKSTC LLRGHTDWVN AVRVDSASRT
510 520 530 540 550
VFSASDDCTV KLWDLDTKSC IRTFHGHVGQ VQQVVPLPRE FEFEDHDVEC
560 570 580 590 600
ENDNVSVTSG DSPAASPQAL PGFDGQTSDT PSSAFGPAFD DGRPSPPRYI
610 620 630 640 650
VTSALDSTIR LWETSSGRCL RTFFGHLEGV WALAADTLRI VSGAEDRMVK
660 670 680 690
IWDPRTGKCE RTFTGHSGPV TCIGLGDSRF ATGSEDCEVR MYSFQT
Length:696
Mass (Da):77,712
Last modified:April 7, 2008 - v1
Checksum:i0377045046AA18C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499595 Genomic DNA. Translation: EDP54913.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00002968; CADAFUBP00002912; CADAFUBG00002968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499595 Genomic DNA. Translation: EDP54913.1.

3D structure databases

ProteinModelPortaliB0XTS1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUBT00002968; CADAFUBP00002912; CADAFUBG00002968.

Phylogenomic databases

HOGENOMiHOG000166480.
OrthoDBiEOG7C5MHX.
PhylomeDBiB0XTS1.

Enzyme and pathway databases

UniPathwayiUPA00143.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
SSF81383. SSF81383. 2 hits.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CEA10 / CBS 144.89 / FGSC A1163.

Entry informationi

Entry nameiSCONB_ASPFC
AccessioniPrimary (citable) accession number: B0XTS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 9, 2010
Last sequence update: April 7, 2008
Last modified: March 31, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.