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B0XS72

- KYNU1_ASPFC

UniProt

B0XS72 - KYNU1_ASPFC

Protein

Kynureninase 1

Gene

bna5-1

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

    Catalytic activityi

    L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
    L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei169 – 1691Pyridoxal phosphate; via amide nitrogenUniRule annotation
    Binding sitei170 – 1701Pyridoxal phosphateUniRule annotation
    Binding sitei283 – 2831Pyridoxal phosphateUniRule annotation
    Binding sitei286 – 2861Pyridoxal phosphateUniRule annotation
    Binding sitei308 – 3081Pyridoxal phosphateUniRule annotation
    Binding sitei349 – 3491Pyridoxal phosphateUniRule annotation
    Binding sitei377 – 3771Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. kynureninase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
    4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    5. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00329.
    UPA00334; UER00455.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kynureninase 1UniRule annotation (EC:3.7.1.3UniRule annotation)
    Alternative name(s):
    Biosynthesis of nicotinic acid protein 5-1UniRule annotation
    L-kynurenine hydrolase 1UniRule annotation
    Gene namesi
    Name:bna5-1
    ORF Names:AFUB_026170
    OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
    Taxonomic identifieri451804 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001699: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Kynureninase 1PRO_0000356963Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei309 – 3091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliB0XS72.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni197 – 2004Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the kynureninase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000242438.
    OrthoDBiEOG7V1G0J.
    PhylomeDBiB0XS72.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01970. Kynureninase.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR14084. PTHR14084. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038800. KYNU. 1 hit.
    SUPFAMiSSF53383. SSF53383. 2 hits.
    TIGRFAMsiTIGR01814. kynureninase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0XS72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSRLHVQVI HGGPPLPYKD DIRAFGKEYA EQLDAQDPLR RFRDEFIIPS    50
    KKDLKRKTLF PNDGMYSCGH PICFANTSCA CVHAAETEET SDEKCIYLCG 100
    NSLGLQPRST RKYIDHYLRT WATKGVTGHF VPHDDQLLPP FVDVDEAGAK 150
    LMAPIVGALK SEVAVMGTLT ANLHLLMASF YRPTPERNKI IIEGKAFPSD 200
    HYAVESQIRH HNLDPKDAMV LIEPEDLDRP ILDTKYILRV IDENAHSTAL 250
    ILLPAIQFYT GQYFDIQRIT AHAQSKGILV GWDCAHAAGN VDLRLHDWNV 300
    DFAAWCTYKY LNAGPGGMAA LFVHERHGRV DIEQAASGKE AFHPRFSGWW 350
    GGDKQTRFLM NNHFVPQQGA AGFQLSNPSV LDMNAVVASL ELFNQTSMAE 400
    IRKKSLNLTG YLEHLLLRDP QTENSEKRPF SIITPSNPAE RGAQLSIRLQ 450
    PGLLDRVLES LNEDAVIIDE RKPDVIRVAP APLYNTYAEV WRFAQLFHLA 500
    CDKALCGRK 509
    Length:509
    Mass (Da):57,148
    Last modified:April 8, 2008 - v1
    Checksum:iFAB6BF3A24F37D13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499595 Genomic DNA. Translation: EDP54558.1.

    Genome annotation databases

    EnsemblFungiiCADAFUBT00002611; CADAFUBP00002557; CADAFUBG00002611.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499595 Genomic DNA. Translation: EDP54558.1 .

    3D structure databases

    ProteinModelPortali B0XS72.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUBT00002611 ; CADAFUBP00002557 ; CADAFUBG00002611 .

    Phylogenomic databases

    HOGENOMi HOG000242438.
    OrthoDBi EOG7V1G0J.
    PhylomeDBi B0XS72.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00329 .
    UPA00334 ; UER00455 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01970. Kynureninase.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR010111. Kynureninase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR14084. PTHR14084. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038800. KYNU. 1 hit.
    SUPFAMi SSF53383. SSF53383. 2 hits.
    TIGRFAMsi TIGR01814. kynureninase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CEA10 / CBS 144.89 / FGSC A1163.

    Entry informationi

    Entry nameiKYNU1_ASPFC
    AccessioniPrimary (citable) accession number: B0XS72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3