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Protein

Kynureninase 1

Gene

bna5-1

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase 2 (bna5-2), Kynureninase 1 (bna5-1)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (bna4)
  2. Kynureninase 2 (bna5-2), Kynureninase 1 (bna5-1)
  3. 3-hydroxyanthranilate 3,4-dioxygenase 1 (bna1-1), 3-hydroxyanthranilate 3,4-dioxygenase 2 (bna1-2)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei170Pyridoxal phosphateUniRule annotation1
Binding sitei283Pyridoxal phosphateUniRule annotation1
Binding sitei286Pyridoxal phosphateUniRule annotation1
Binding sitei308Pyridoxal phosphateUniRule annotation1
Binding sitei349Pyridoxal phosphateUniRule annotation1
Binding sitei377Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPyridine nucleotide biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
Kynureninase 1UniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5-1UniRule annotation
L-kynurenine hydrolase 1UniRule annotation
Gene namesi
Name:bna5-1
ORF Names:AFUB_026170
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000001699 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003569631 – 509Kynureninase 1Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei309N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiB0XS72

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0XS72
SMRiB0XS72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni197 – 200Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242438
OrthoDBiEOG092C20ON
PhylomeDBiB0XS72

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 3 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 2 hits
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

B0XS72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRLHVQVI HGGPPLPYKD DIRAFGKEYA EQLDAQDPLR RFRDEFIIPS
60 70 80 90 100
KKDLKRKTLF PNDGMYSCGH PICFANTSCA CVHAAETEET SDEKCIYLCG
110 120 130 140 150
NSLGLQPRST RKYIDHYLRT WATKGVTGHF VPHDDQLLPP FVDVDEAGAK
160 170 180 190 200
LMAPIVGALK SEVAVMGTLT ANLHLLMASF YRPTPERNKI IIEGKAFPSD
210 220 230 240 250
HYAVESQIRH HNLDPKDAMV LIEPEDLDRP ILDTKYILRV IDENAHSTAL
260 270 280 290 300
ILLPAIQFYT GQYFDIQRIT AHAQSKGILV GWDCAHAAGN VDLRLHDWNV
310 320 330 340 350
DFAAWCTYKY LNAGPGGMAA LFVHERHGRV DIEQAASGKE AFHPRFSGWW
360 370 380 390 400
GGDKQTRFLM NNHFVPQQGA AGFQLSNPSV LDMNAVVASL ELFNQTSMAE
410 420 430 440 450
IRKKSLNLTG YLEHLLLRDP QTENSEKRPF SIITPSNPAE RGAQLSIRLQ
460 470 480 490 500
PGLLDRVLES LNEDAVIIDE RKPDVIRVAP APLYNTYAEV WRFAQLFHLA

CDKALCGRK
Length:509
Mass (Da):57,148
Last modified:April 8, 2008 - v1
Checksum:iFAB6BF3A24F37D13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499595 Genomic DNA Translation: EDP54558.1

Genome annotation databases

EnsemblFungiiCADAFUBT00002611; CADAFUBP00002557; CADAFUBG00002611

Similar proteinsi

Entry informationi

Entry nameiKYNU1_ASPFC
AccessioniPrimary (citable) accession number: B0XS72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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