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Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei190PROSITE-ProRule annotation1
Active sitei390PROSITE-ProRule annotation1
Active sitei452PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

ESTHERiaspfu-kex1. Carboxypeptidase_S10.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:kex1
ORF Names:AFUB_008360
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000001699 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 523LumenalSequence analysisAdd BLAST485
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 632CytoplasmicSequence analysisAdd BLAST88

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000041190339 – 632Pheromone-processing carboxypeptidase kex1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi449N-linked (GlcNAc...)Sequence analysis1
Glycosylationi501N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB0XQ16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 30Poly-Leu8

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
OrthoDBiEOG092C255X.
PhylomeDBiB0XQ16.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0XQ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLTTPSSRG SRAQSGIANV SWLALSLLLL FSPTLGSAKS AADYYVRSLP
60 70 80 90 100
GAPEGPLLKM HAGHIEVDAQ NNGNLFFWHY QNRHIANRQR TVIWLNGGPG
110 120 130 140 150
CSSMDGALME IGPYRLKDNH TLEYNNGSWD EFANLLFVDQ PVGTGFSYVN
160 170 180 190 200
TNSYIHELDE MSAQFITFLE KWFQLFPEYE GDDIYIAGES YAGQHIPYIA
210 220 230 240 250
KAIQERNNKI QNDQSIRWNL RGIVIGNGWI SPAQQYPSYL TFAYEEGLVT
260 270 280 290 300
KGSSLAKDLE VYQSVCESKI SASPNAINIR DCEEILQQIL ARTKDTNKQC
310 320 330 340 350
YNMYDVRLRD TYPSCGMNWP TDLVDVKPYL QRPDVVQALN INPEKKSGWE
360 370 380 390 400
ECSGAVSSTF NAANSLPSVQ LLPELLESGI PILLFSGDKD LICNHVGTEQ
410 420 430 440 450
LINNMKWNGG TGFETSPGVW APRHDWTFEG EPAGIYQYAR NLTYVLFYNA
460 470 480 490 500
SHMVPYDLPR QSRDMLDRFM KVDIANIGGK PADSRIDGEK LPQTSVGGHP
510 520 530 540 550
NSTAAEQQAK EKIKETEWKA YAKSGEAALI VVIIGVTVWG FFIWRSRRRN
560 570 580 590 600
RGYQGVYQRD IGSGSILERF HNKRSGPADV EAGDFDESEL DNLHSPGLEQ
610 620 630
EHYAVGDDSD EESPNHQPAA PPSSTKPGGA QP
Length:632
Mass (Da):70,499
Last modified:April 8, 2008 - v1
Checksum:iAFF7584F825F78C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499594 Genomic DNA. Translation: EDP56130.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00000840; CADAFUBP00000820; CADAFUBG00000840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499594 Genomic DNA. Translation: EDP56130.1.

3D structure databases

ProteinModelPortaliB0XQ16.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiaspfu-kex1. Carboxypeptidase_S10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUBT00000840; CADAFUBP00000820; CADAFUBG00000840.

Phylogenomic databases

HOGENOMiHOG000208879.
OrthoDBiEOG092C255X.
PhylomeDBiB0XQ16.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_ASPFC
AccessioniPrimary (citable) accession number: B0XQ16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.