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B0XQ16

- KEX1_ASPFC

UniProt

B0XQ16 - KEX1_ASPFC

Protein

Pheromone-processing carboxypeptidase kex1

Gene

kex1

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei190 – 1901PROSITE-ProRule annotation
    Active sitei390 – 3901PROSITE-ProRule annotation
    Active sitei452 – 4521PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase kex1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:kex1
    ORF Names:AFUB_008360
    OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
    Taxonomic identifieri451804 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000001699: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3838Sequence AnalysisAdd
    BLAST
    Chaini39 – 632594Pheromone-processing carboxypeptidase kex1PRO_0000411903Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi449 – 4491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliB0XQ16.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini39 – 523485LumenalSequence AnalysisAdd
    BLAST
    Topological domaini545 – 63288CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei524 – 54421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi23 – 308Poly-Leu

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000208879.
    OrthoDBiEOG7TJ3SJ.
    PhylomeDBiB0XQ16.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B0XQ16-1 [UniParc]FASTAAdd to Basket

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    MLLTTPSSRG SRAQSGIANV SWLALSLLLL FSPTLGSAKS AADYYVRSLP    50
    GAPEGPLLKM HAGHIEVDAQ NNGNLFFWHY QNRHIANRQR TVIWLNGGPG 100
    CSSMDGALME IGPYRLKDNH TLEYNNGSWD EFANLLFVDQ PVGTGFSYVN 150
    TNSYIHELDE MSAQFITFLE KWFQLFPEYE GDDIYIAGES YAGQHIPYIA 200
    KAIQERNNKI QNDQSIRWNL RGIVIGNGWI SPAQQYPSYL TFAYEEGLVT 250
    KGSSLAKDLE VYQSVCESKI SASPNAINIR DCEEILQQIL ARTKDTNKQC 300
    YNMYDVRLRD TYPSCGMNWP TDLVDVKPYL QRPDVVQALN INPEKKSGWE 350
    ECSGAVSSTF NAANSLPSVQ LLPELLESGI PILLFSGDKD LICNHVGTEQ 400
    LINNMKWNGG TGFETSPGVW APRHDWTFEG EPAGIYQYAR NLTYVLFYNA 450
    SHMVPYDLPR QSRDMLDRFM KVDIANIGGK PADSRIDGEK LPQTSVGGHP 500
    NSTAAEQQAK EKIKETEWKA YAKSGEAALI VVIIGVTVWG FFIWRSRRRN 550
    RGYQGVYQRD IGSGSILERF HNKRSGPADV EAGDFDESEL DNLHSPGLEQ 600
    EHYAVGDDSD EESPNHQPAA PPSSTKPGGA QP 632
    Length:632
    Mass (Da):70,499
    Last modified:April 8, 2008 - v1
    Checksum:iAFF7584F825F78C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499594 Genomic DNA. Translation: EDP56130.1.

    Genome annotation databases

    EnsemblFungiiCADAFUBT00000840; CADAFUBP00000820; CADAFUBG00000840.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS499594 Genomic DNA. Translation: EDP56130.1 .

    3D structure databases

    ProteinModelPortali B0XQ16.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUBT00000840 ; CADAFUBP00000820 ; CADAFUBG00000840 .

    Phylogenomic databases

    HOGENOMi HOG000208879.
    OrthoDBi EOG7TJ3SJ.
    PhylomeDBi B0XQ16.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CEA10 / CBS 144.89 / FGSC A1163.

    Entry informationi

    Entry nameiKEX1_ASPFC
    AccessioniPrimary (citable) accession number: B0XQ16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3