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B0XNY2

- BGALB_ASPFC

UniProt

B0XNY2 - BGALB_ASPFC

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Protein
Probable beta-galactosidase B
Gene
lacB, AFUB_016080
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901Substrate By similarity
Binding sitei135 – 1351Substrate By similarity
Binding sitei136 – 1361Substrate; via amide nitrogen By similarity
Binding sitei137 – 1371Substrate By similarity
Binding sitei195 – 1951Substrate By similarity
Active sitei196 – 1961Proton donor Reviewed prediction
Binding sitei265 – 2651Substrate By similarity
Active sitei308 – 3081Nucleophile Reviewed prediction
Binding sitei373 – 3731Substrate By similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase B (EC:3.2.1.23)
Alternative name(s):
Lactase B
Gene namesi
Name:lacB
ORF Names:AFUB_016080
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001699: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 1015995Probable beta-galactosidase B
PRO_0000395223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi211 – 2111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi271 ↔ 324 By similarity
Glycosylationi411 – 4111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi456 – 4561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi554 – 5541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi679 – 6791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi735 – 7351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi775 – 7751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi821 – 8211N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB0XNY2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000181922.
OrthoDBiEOG7ZGXBD.
PhylomeDBiB0XNY2.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SMARTiSM01029. BetaGal_dom2. 1 hit.
[Graphical view]
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0XNY2-1 [UniParc]FASTAAdd to Basket

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MAHIYRLLLL LLSNLWFSTA AQNQSETEWP LHDNGLSKVV QWDHYSFQVN     50
GQRIFIFSGE FHYWRIPVPE LWRDILEKVK ATGFTAFAFY SSWAYHAPNN 100
STVDFSTGAR DITPIFELAK ELGMYMIVRP GPYVNAEASA GGFPLWLMTG 150
EYGSLRNDDP RYTAAWTPYF ANMSQITSKY QVTDGHNTLV YQIENEYGQQ 200
WIGDPKNRNP NKTAVAYMEL LEASARENGI TVPLTSNDPN MNSKSWGSDW 250
SNAGGNVDVA GLDSYPSCWT CDVSQCTSTN GEYVPYKVID YYDYFQEVQP 300
TLPSFMPEFQ GGSYNPWAGP EGGCPQDTSA EFANLFYRWN IGQRVTAMSL 350
YMLYGGTNWG AIAAPVTATS YDYSAPISED RSIGAKYSET KLLALFTRTA 400
KDLTMTEAIG NGTQYTTNTA VRAFELRNPQ TNAGFYVTFH TDTTVGGNQA 450
FKLHVNTSVG ALTVPKNEGL IQLNGHQSKI IVTDFTLGKR TLLYSTAEVL 500
TYAVFENRPT LVLWVPTGES GEFAIKGAKS GKVENGDGCS GIKFKREKDY 550
LVVNFSQAKG LSVLRLDNGV RVVLLDKAAA YRFWAPALTD DPNVQETETV 600
LVHGPYLVRS ASISKTTLAL RGDSVEKTTL EIFAPHSVRK ITWNGKEVQT 650
SHTPYGSLKA TLAAPPDIKL PALTSWRSND SLPERLPSYD DSGPAWIEAN 700
HMTTSNPSPP ATFPVLYADE YGFHNGVRLW RGYFNGSASG VFLNIQGGSA 750
FGWSAWLNGH FLDSHLGTAT TSQANKTLTF PSSILNPTEN VLLIVHDDTG 800
HDQTTGALNP RGILEARLLS NDTSSPPPEF THWRLAGTAG GESNLDPIRG 850
VFNEDGLFAE RMGWHLPGFD DSAWTSENSA TSASSALSFT GATVRFFRSV 900
VPLNIPAGLD VSISFVLSTP TAAPKGYRAQ LFVNGYQYGR YNPHIGNQVV 950
FPVPPGILDY QGDNTIGLAV WAQTEEGAGI QVDWKVNYVA DSSLSVAGFG 1000
KGLRPGWTEE RLKFA 1015
Length:1,015
Mass (Da):111,681
Last modified:April 8, 2008 - v1
Checksum:iD9EB8677F99A13A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS499594 Genomic DNA. Translation: EDP56886.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00001613; CADAFUBP00001576; CADAFUBG00001613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS499594 Genomic DNA. Translation: EDP56886.1 .

3D structure databases

ProteinModelPortali B0XNY2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUBT00001613 ; CADAFUBP00001576 ; CADAFUBG00001613 .

Phylogenomic databases

HOGENOMi HOG000181922.
OrthoDBi EOG7ZGXBD.
PhylomeDBi B0XNY2.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SMARTi SM01029. BetaGal_dom2. 1 hit.
[Graphical view ]
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CEA10 / CBS 144.89 / FGSC A1163.

Entry informationi

Entry nameiBGALB_ASPFC
AccessioniPrimary (citable) accession number: B0XNY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi