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Protein

Probable glucan 1,3-beta-glucosidase A

Gene

exgA

Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity).By similarity

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei211 – 2111Proton donorBy similarity
Active sitei308 – 3081NucleophileBy similarity

GO - Molecular functioni

  1. glucan endo-1,6-beta-glucosidase activity Source: EnsemblFungi
  2. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase A (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase 1
Exo-1,3-beta-glucanase A
Gene namesi
Name:exgA
Synonyms:exg1
ORF Names:AFUB_004010
OrganismiNeosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)
Taxonomic identifieri451804 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000001699 Componenti: Unassembled WGS sequence

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. barrier septum Source: EnsemblFungi
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 416394Probable glucan 1,3-beta-glucosidase APRO_0000393528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi291 ↔ 415By similarity
Disulfide bondi316 ↔ 342By similarity
Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliB0XN12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000114462.
OrthoDBiEOG7JT75H.
PhylomeDBiB0XN12.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0XN12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFKFSQKAL VALYLVVGLA EAVPSKSRVV SRASTFDYNG IVRGVNIGGW
60 70 80 90 100
LVLEPWITPS IFDNAGDAAV DEWTLTATLG QDQAKAVLSQ HWSTFITQDD
110 120 130 140 150
FQQIAQAGMN HVRIPIGYWA VSSLPDEPYV DGQLEYLDNA ISWAREAGLK
160 170 180 190 200
VVIDLHGAPG SQNGFDNSGR KGPIAWQQGD TVSQTVDAFR ALAERYLPQS
210 220 230 240 250
DVVTAIEALN EPNIPGGVSE AGLRDYYNQI ADVVRQIDPD TSVFLSDGFL
260 270 280 290 300
STESWNGFKT GEDVVMDTHH YEMFDNYLIS LDIDGHVKSA CDFGKQIEGS
310 320 330 340 350
DKPVVVGEWS GAVTDCTKHL NGKGVSTRYQ GEYANNVKYG DCANTTQGSV
360 370 380 390 400
ADLSDQERTD TRRFIEAQLD AYEGKNGWLF WTWKTEGAPG WDMQDLLANG
410
VFPSPLTDRQ FPNQCA
Length:416
Mass (Da):45,745
Last modified:April 7, 2008 - v1
Checksum:iB55EB08627F6F28D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499594 Genomic DNA. Translation: EDP55704.1.

Genome annotation databases

EnsemblFungiiCADAFUBT00000402; CADAFUBP00000394; CADAFUBG00000402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS499594 Genomic DNA. Translation: EDP55704.1.

3D structure databases

ProteinModelPortaliB0XN12.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUBT00000402; CADAFUBP00000394; CADAFUBG00000402.

Phylogenomic databases

HOGENOMiHOG000114462.
OrthoDBiEOG7JT75H.
PhylomeDBiB0XN12.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CEA10 / CBS 144.89 / FGSC A1163.

Entry informationi

Entry nameiEXGA_ASPFC
AccessioniPrimary (citable) accession number: B0XN12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 19, 2010
Last sequence update: April 7, 2008
Last modified: March 31, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.