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Protein

L-lactate dehydrogenase

Gene

6050294

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (6050294), L-lactate dehydrogenase (6047928)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei192Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:6050294Imported
ORF Names:CpipJ_CPIJ016131Imported
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)Imported
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
Proteomesi
  • UP000002320 Componenti: Partially assembled WGS sequence

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi7176.CPIJ016131-PA.

Structurei

3D structure databases

ProteinModelPortaliB0XBA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 159Ldh_1_NInterPro annotationAdd BLAST139
Domaini162 – 324Ldh_1_CInterPro annotationAdd BLAST163

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
HOGENOMiHOG000213793.
InParanoidiB0XBA2.
KOiK00016.
OMAiDQWKNIH.
OrthoDBiEOG091G0HME.
PhylomeDBiB0XBA2.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

B0XBA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKSKLMME IAEPMTSSGN KVTVVGIGQV GMACAFSILT QSVSSEVALI
60 70 80 90 100
DVNADKLQGE MLDLQHGSAF MKNAQVQAST DFAVSAGSRL IVITAGVRQK
110 120 130 140 150
EGESRLNLVQ RNCDILKGII PKLVEHSPDC ILLMVSNPVD IMTYVAWKIS
160 170 180 190 200
GLPKNRVIGS GTNLDSSRFR FLMSQRLGVA PTSCHGWIIG EHGDSSVPVW
210 220 230 240 250
SGVNVAGVRL AEINPSIGTA DDDEKWGELH HEVVNSAYEV IKLKGYTSWA
260 270 280 290 300
IGLSVASLAS ALLRNTYNVH AVSTLVTGEH GINEEVYLSL PCVLGRNGVS
310 320 330
HVVKQILTEA ETKKLQESAK IMSEVQAGIK F
Length:331
Mass (Da):35,571
Last modified:April 8, 2008 - v1
Checksum:i33C3EF3B854C2F0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232622 Genomic DNA. Translation: EDS44193.1.
RefSeqiXP_001866924.1. XM_001866889.1.

Genome annotation databases

EnsemblMetazoaiCPIJ016131-RA; CPIJ016131-PA; CPIJ016131.
GeneIDi6050294.
KEGGicqu:CpipJ_CPIJ016131.
VectorBaseiCPIJ016131-RA; CPIJ016131-PA; CPIJ016131.

Similar proteinsi

Entry informationi

Entry nameiB0XBA2_CULQU
AccessioniPrimary (citable) accession number: B0XBA2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 25, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported