ID   B0XAP5_CULQU            Unreviewed;      1011 AA.
AC   B0XAP5;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   SubName: Full=Histone-lysine N-methyltransferase SETDB1 {ECO:0000313|EMBL:EDS43834.1};
GN   ORFNames=CpipJ_CPIJ016652 {ECO:0000313|EMBL:EDS43834.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS43834.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS43834.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; DS232592; EDS43834.1; -; Genomic_DNA.
DR   RefSeq; XP_001866717.1; XM_001866682.1.
DR   AlphaFoldDB; B0XAP5; -.
DR   STRING; 7176.B0XAP5; -.
DR   KEGG; cqu:CpipJ_CPIJ016652; -.
DR   VEuPathDB; VectorBase:CPIJ016652; -.
DR   VEuPathDB; VectorBase:CQUJHB007565; -.
DR   eggNOG; KOG1141; Eukaryota.
DR   HOGENOM; CLU_003279_0_1_1; -.
DR   InParanoid; B0XAP5; -.
DR   OMA; LLCCDCE; -.
DR   OrthoDB; 2877903at2759; -.
DR   PhylomeDB; B0XAP5; -.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd01395; HMT_MBD; 1.
DR   CDD; cd10517; SET_SETDB1; 1.
DR   CDD; cd21181; Tudor_SETDB1_rpt2; 1.
DR   Gene3D; 2.30.30.140; -; 2.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR047232; SETDB1/2-like_MBD.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR041292; Tudor_4.
DR   InterPro; IPR041291; TUDOR_5.
DR   PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR   PANTHER; PTHR46024:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR   Pfam; PF01429; MBD; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF18358; Tudor_4; 1.
DR   Pfam; PF18359; Tudor_5; 1.
DR   SMART; SM00391; MBD; 1.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00333; TUDOR; 2.
DR   SUPFAM; SSF54171; DNA-binding domain; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50982; MBD; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Methyltransferase {ECO:0000313|EMBL:EDS43834.1};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EDS43834.1}.
FT   DOMAIN          541..608
FT                   /note="MBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50982"
FT   DOMAIN          670..742
FT                   /note="Pre-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50867"
FT   DOMAIN          745..986
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          995..1011
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          425..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          816..904
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        830..845
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        860..894
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1011 AA;  115310 MW;  4294AE60F64C05E4 CRC64;
     MPRKNELVEI SDSSEEEEDA DTKSETEKPL PEDIVALIDT ELNDILTSTF EKINLEQQIE
     WTEQIMKQKI AYNTKISDEI NNELNELQRK VDRIHLQLYS KSRPKYQDLP PCNIFHEVDL
     LGKAHITTQS QPAATPTNRQ YSPQKQHQSA TPSQQAPAAT AAAAKEEFVR PAVIVGQFYF
     AVKHKLLSNW AECQVVEAVN VADKALYKVN FLFNQGAGSA PIKVVPAKYL AYRHSFNVKL
     PLGTRVIARF DAGSSTAPPG KANQQMQAKT NAFYPGIIAE SFGKYNRHRY LIFFDDGYAQ
     YVSHGDVRVV CEESKEVWAD IHPHSQEFIK AYLQNYRSQR PMVQVKVGQR IITEWKGKWI
     YAKVVDIDAS LVQLFFPDDN RHEWIYRGST RLGPLYQEKA LSMTKANNKF SKFQKRNEPS
     IEYITLDDDD DDQNKQSDAK KAQPSQDLQQ YNKTLQQTML DNAAANRSVA KKSTFNRPVP
     AAPAAPQQPS AVFMNSSTIY CEDDRPKGKI VYYTAKKHLP PLKYKQHQCS PSCLFKITHN
     LKSYSPLAKP LLSGWERQLC KMKYKKVFVV YRGPCGRRLR NMYELHMYLR MTNATLNVEN
     FDFDPVIHCL AEYVIENHIY HNPDLSDGKE YMAVPCVNYF DDTKPPPCIY STERIPTEGV
     NLNLDEDFMC GCDCEDDCID KSRCQCWQLT VAGAKFTNQN TPIDNIGYVY KRLQEPVLTG
     IYECNSRCKC KTNCLNRVVQ HPLQTKLQVF KTSNRGWGIR CLNDVSKGSF ICIYSGHLLT
     EEAGNNICQS NSNKAGDEYF ADLDYIETVE QLKEGYEADV VESESENDSD GPDYDAKRDS
     DASDDDFTSS INPSDAAVKT RAQLRKDAKK SDKKSQKKKE DPKQDSDDAE REMISVMPNT
     DMVKGDVASP SIKYRSVRKL FGKHEQIYIM DAKKSGNLGR YFNHSCNPNL FVQNVFVDTH
     DLRFPWVAFF ALSNIRAGSE LTWNYNYDVG SVPGKVLYCQ CGAENCRQRL L
//