B0XAP5 (B0XAP5_CULQU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Histone-lysine N-methyltransferase SETDB1 EMBL EDS43834.1

Gene names

ORF Names:

CpipJ_CPIJ016652 EMBL EDS43834.1

Organism

Culex quinquefasciatus (Southern house mosquito) (Culex pungens) [Complete proteome]

Taxonomic identifier

7176 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicimorpha › Culicoidea › Culicidae › Culicinae › Culicini › Culex › Culex › Culex pipiens complex

Protein attributes

Sequence length	1011 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 SET domain. SAAS SAAS007728 RuleBase RU004538 Contains 1 post-SET domain. RuleBase RU004541 Contains 1 pre-SET domain. SAAS SAAS007728

Ontologies

Keywords
Cellular component	Chromosome SAAS SAAS007728 Nucleus SAAS SAAS007728 RuleBase RU004542
Molecular function	Methyltransferase RuleBase RU004542 SAAS SAAS007728 RuleBase RU004541 EMBL EDS43834.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B0XAP5 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 4294AE60F64C05E4	FASTA	1,011	115,310
	10 20 30 40 50 60 MPRKNELVEI SDSSEEEEDA DTKSETEKPL PEDIVALIDT ELNDILTSTF EKINLEQQIE 70 80 90 100 110 120 WTEQIMKQKI AYNTKISDEI NNELNELQRK VDRIHLQLYS KSRPKYQDLP PCNIFHEVDL 130 140 150 160 170 180 LGKAHITTQS QPAATPTNRQ YSPQKQHQSA TPSQQAPAAT AAAAKEEFVR PAVIVGQFYF 190 200 210 220 230 240 AVKHKLLSNW AECQVVEAVN VADKALYKVN FLFNQGAGSA PIKVVPAKYL AYRHSFNVKL 250 260 270 280 290 300 PLGTRVIARF DAGSSTAPPG KANQQMQAKT NAFYPGIIAE SFGKYNRHRY LIFFDDGYAQ 310 320 330 340 350 360 YVSHGDVRVV CEESKEVWAD IHPHSQEFIK AYLQNYRSQR PMVQVKVGQR IITEWKGKWI 370 380 390 400 410 420 YAKVVDIDAS LVQLFFPDDN RHEWIYRGST RLGPLYQEKA LSMTKANNKF SKFQKRNEPS 430 440 450 460 470 480 IEYITLDDDD DDQNKQSDAK KAQPSQDLQQ YNKTLQQTML DNAAANRSVA KKSTFNRPVP 490 500 510 520 530 540 AAPAAPQQPS AVFMNSSTIY CEDDRPKGKI VYYTAKKHLP PLKYKQHQCS PSCLFKITHN 550 560 570 580 590 600 LKSYSPLAKP LLSGWERQLC KMKYKKVFVV YRGPCGRRLR NMYELHMYLR MTNATLNVEN 610 620 630 640 650 660 FDFDPVIHCL AEYVIENHIY HNPDLSDGKE YMAVPCVNYF DDTKPPPCIY STERIPTEGV 670 680 690 700 710 720 NLNLDEDFMC GCDCEDDCID KSRCQCWQLT VAGAKFTNQN TPIDNIGYVY KRLQEPVLTG 730 740 750 760 770 780 IYECNSRCKC KTNCLNRVVQ HPLQTKLQVF KTSNRGWGIR CLNDVSKGSF ICIYSGHLLT 790 800 810 820 830 840 EEAGNNICQS NSNKAGDEYF ADLDYIETVE QLKEGYEADV VESESENDSD GPDYDAKRDS 850 860 870 880 890 900 DASDDDFTSS INPSDAAVKT RAQLRKDAKK SDKKSQKKKE DPKQDSDDAE REMISVMPNT 910 920 930 940 950 960 DMVKGDVASP SIKYRSVRKL FGKHEQIYIM DAKKSGNLGR YFNHSCNPNL FVQNVFVDTH 970 980 990 1000 1010 DLRFPWVAFF ALSNIRAGSE LTWNYNYDVG SVPGKVLYCQ CGAENCRQRL L

References

[1]

"Annotation of Culex pipiens quinquefasciatus." The Broad Institute Genome Sequencing Platform Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D., Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E., Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P., Antoine C.H. , Arensburger P., Bidwell S.L., Crawford M., Camaro F., Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D., Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J., Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E., Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JHB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS232592 Genomic DNA. Translation: EDS43834.1.
RefSeq	XP_001866717.1. XM_001866682.1.
3D structure databases
ProteinModelPortal	B0XAP5.
ModBase	Search...
Protein-protein interaction databases
STRING	7176.CPIJ016652-PA.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6050045.
KEGG	cqu:CpipJ_CPIJ016652.
VectorBase	CPIJ016652. Culex quinquefasciatus.
Phylogenomic databases
eggNOG	COG2940.
HOGENOM	HOG000047815.
KO	K11421.
OMA	CKCKKNC.
OrthoDB	EOG4THT82.
PhylomeDB	B0XAP5.
Family and domain databases
Gene3D	3.30.890.10. 1 hit.
InterPro	IPR016177. DNA-bd_integrase-typ. IPR001739. Methyl_CpG_DNA-bd. IPR003616. Post-SET_dom. IPR007728. Pre-SET_dom. IPR001214. SET_dom. IPR002999. Tudor. [Graphical view]
Pfam	PF01429. MBD. 1 hit. PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. SM00333. TUDOR. 2 hits. [Graphical view]
SUPFAM	SSF54171. DNA-binding_integrase-type. 1 hit.
PROSITE	PS50982. MBD. 1 hit. PS50868. POST_SET. 1 hit. PS50867. PRE_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B0XAP5_CULQU

Accession

Primary (citable) accession number: B0XAP5

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	April 3, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)