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Protein
Submitted name:

Histone-lysine N-methyltransferase SETDB1

Gene

CpipJ_CPIJ016652

Organism
Culex quinquefasciatus (Southern house mosquito) (Culex pungens)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseSAAS annotationImported, Transferase
LigandS-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Histone-lysine N-methyltransferase SETDB1Imported
Gene namesi
ORF Names:CpipJ_CPIJ016652Imported
OrganismiCulex quinquefasciatus (Southern house mosquito) (Culex pungens)Imported
Taxonomic identifieri7176 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeCuliciniCulexCulex
Proteomesi
  • UP000002320 Componenti: Partially assembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7176.CPIJ802311-PA.

Structurei

3D structure databases

ProteinModelPortaliB0XAP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini541 – 608MBDInterPro annotationAdd BLAST68
Domaini670 – 742Pre-SETInterPro annotationAdd BLAST73
Domaini745 – 986SETInterPro annotationAdd BLAST242
Domaini995 – 1011Post-SETInterPro annotationAdd BLAST17

Phylogenomic databases

eggNOGiKOG1141. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000047815.
InParanoidiB0XAP5.
KOiK11421.
OMAiTSMHQSR.
OrthoDBiEOG091G014F.
PhylomeDBiB0XAP5.

Family and domain databases

InterProiView protein in InterPro
IPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
IPR002999. Tudor.
PfamiView protein in Pfam
PF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00391. MBD. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00333. TUDOR. 2 hits.
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiView protein in PROSITE
PS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

B0XAP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRKNELVEI SDSSEEEEDA DTKSETEKPL PEDIVALIDT ELNDILTSTF
60 70 80 90 100
EKINLEQQIE WTEQIMKQKI AYNTKISDEI NNELNELQRK VDRIHLQLYS
110 120 130 140 150
KSRPKYQDLP PCNIFHEVDL LGKAHITTQS QPAATPTNRQ YSPQKQHQSA
160 170 180 190 200
TPSQQAPAAT AAAAKEEFVR PAVIVGQFYF AVKHKLLSNW AECQVVEAVN
210 220 230 240 250
VADKALYKVN FLFNQGAGSA PIKVVPAKYL AYRHSFNVKL PLGTRVIARF
260 270 280 290 300
DAGSSTAPPG KANQQMQAKT NAFYPGIIAE SFGKYNRHRY LIFFDDGYAQ
310 320 330 340 350
YVSHGDVRVV CEESKEVWAD IHPHSQEFIK AYLQNYRSQR PMVQVKVGQR
360 370 380 390 400
IITEWKGKWI YAKVVDIDAS LVQLFFPDDN RHEWIYRGST RLGPLYQEKA
410 420 430 440 450
LSMTKANNKF SKFQKRNEPS IEYITLDDDD DDQNKQSDAK KAQPSQDLQQ
460 470 480 490 500
YNKTLQQTML DNAAANRSVA KKSTFNRPVP AAPAAPQQPS AVFMNSSTIY
510 520 530 540 550
CEDDRPKGKI VYYTAKKHLP PLKYKQHQCS PSCLFKITHN LKSYSPLAKP
560 570 580 590 600
LLSGWERQLC KMKYKKVFVV YRGPCGRRLR NMYELHMYLR MTNATLNVEN
610 620 630 640 650
FDFDPVIHCL AEYVIENHIY HNPDLSDGKE YMAVPCVNYF DDTKPPPCIY
660 670 680 690 700
STERIPTEGV NLNLDEDFMC GCDCEDDCID KSRCQCWQLT VAGAKFTNQN
710 720 730 740 750
TPIDNIGYVY KRLQEPVLTG IYECNSRCKC KTNCLNRVVQ HPLQTKLQVF
760 770 780 790 800
KTSNRGWGIR CLNDVSKGSF ICIYSGHLLT EEAGNNICQS NSNKAGDEYF
810 820 830 840 850
ADLDYIETVE QLKEGYEADV VESESENDSD GPDYDAKRDS DASDDDFTSS
860 870 880 890 900
INPSDAAVKT RAQLRKDAKK SDKKSQKKKE DPKQDSDDAE REMISVMPNT
910 920 930 940 950
DMVKGDVASP SIKYRSVRKL FGKHEQIYIM DAKKSGNLGR YFNHSCNPNL
960 970 980 990 1000
FVQNVFVDTH DLRFPWVAFF ALSNIRAGSE LTWNYNYDVG SVPGKVLYCQ
1010
CGAENCRQRL L
Length:1,011
Mass (Da):115,310
Last modified:April 8, 2008 - v1
Checksum:i4294AE60F64C05E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS232592 Genomic DNA. Translation: EDS43834.1.
RefSeqiXP_001866717.1. XM_001866682.1.

Genome annotation databases

EnsemblMetazoaiCPIJ016652-RA; CPIJ016652-PA; CPIJ016652.
GeneIDi6050045.
KEGGicqu:CpipJ_CPIJ016652.

Similar proteinsi

Entry informationi

Entry nameiB0XAP5_CULQU
AccessioniPrimary (citable) accession number: B0XAP5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 27, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported